Citation: DING Jie, ZHANG Shenghu, LIU Jining, ZHOU Linjun, CHEN Guosong, SHI Lili. Determination of bisphenol A, tetrabromobisphenol A and alkylphenols in water samples of sewage treatment plant using liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2014, 32(5): 529-534. doi: 10.3724/SP.J.1123.2013.12043 shu

Determination of bisphenol A, tetrabromobisphenol A and alkylphenols in water samples of sewage treatment plant using liquid chromatography-tandem mass spectrometry

DING Jie ^1,2 ,
ZHANG Shenghu ¹ ,
LIU Jining ^1,, ,
ZHOU Linjun ¹ ,
CHEN Guosong ² ,
SHI Lili ¹

1.
1. Nanjing Institute of Environmental Sciences, Ministry of Environmental Protection, Nanjing 210042, China;

Corresponding author: LIU Jining,
Received Date: 31 December 2013
Available Online: 5 March 2014
Fund Project: 国家高技术研究发展计划(“863”计划)项目(2013AA06A308) (“863”计划)项目(2013AA06A308)环保公益性行业科研专项(201309028). (201309028)

Bisphenol A, tetrabromobisphenol A and alkylphenols have received much attention in recent years because of their endocrine disrupting effects to aquatic ecosystem. The fate of these compounds in sewage treatment plant which is important to deal with this kind of compounds has significance on the study of exposure levels of the target compounds in the environment, and the development of analytical method is the basis on the above study. An analytical method based on liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) with negative ionization mode has been developed for measuring bisphenol A, tetrabromobisphenol A and six alkylphenols in raw and treated sewage samples. The target compounds were separated on a ZORBAX Eclipse Plus C18 column (150 mm×2.1 mm, 3.5 μm) with mobile phases of acetonitril and 0.02% (v/v) ammonia. Analyte confirmations were performed under multiple reaction monitoring (MRM) mode and the eight compounds were separated within 11 min. The calibration curves were linear in the range of 1-100 μg/L (R²≥0.998). The quantification limits of the eight compounds were 2.0-20 ng/L. The recovery experiments were performed with samples spiked at the levels of 0.2, 2 and 20 μg/L, and the recoveries for the target compounds were in the range of 64.3%-118.0%, 65.9%-100.5% and 70.3%-102.7% (RSD<7.1%, n=3), respectively. Based on the analytical method, the raw and treated sewage samples from an industrial park of Jiangsu Province were analyzed. Five compounds were detected in the water outlet in the range of 11.9-3015.3 ng/L. It shows that the method is simple, selective, sensitive and can be used to analyze the water samples of sewage treatment plant containing alkylphenols.
- liquid chromatography-tandem mass spectrometry (HPLC-MS/MS),
- bisphenol A,
- tetrabromobisphenol A,
- alkylphenols,
- water sample,
- sewage treatment plant (STP)
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