Citation: SHAN Yichu, ZHANG Lihua, ZHANG Yukui. Advances and applications of selective reaction monitoring technology in proteomics study[J]. Chinese Journal of Chromatography, ;2014, 32(4): 330-335. doi: 10.3724/SP.J.1123.2013.12019 shu

Advances and applications of selective reaction monitoring technology in proteomics study

1.
Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; National Chromatographic Research and Analysis Center, Dalian 116023, China

Corresponding author: ZHANG Lihua,
Received Date: 18 December 2013
Available Online: 9 January 2014
Fund Project: 国家重大科学计划“蛋白质定量新方法及相关技术研究”项目(2012CB910604). (2012CB910604)

As an important technology for targeted protein analysis, selective reaction monitoring technology (SRM) improves the detection sensitivity and quantification accuracy by eliminating the interference of impurities and co-eluting peptides by selective detection of specific mother ions and daughter ions. It has been widely applied to the quantitative proteomics study due to the advantages of high selectivity, excellent reproducibility, high sensitivity and wide dynamic range and plays an important role in the area of life science. For the quantitative analysis of the complex samples with wide dynamic range, the throughput of analysis and detection sensitivity still need to be improved. Moreover, various quantification strategies have been proposed to improve the accuracy and precision of quantification. Furthermore, data processing becomes more and more important with the application of SRM technology to the analysis of complex samples. In this work, the recent development of SRM technology is reviewed from the above mentioned aspects. Since SRM technology gains wider applications along with the technological development, its applications in the area of proteomics quantitative study including biomarker validation, post-translational proteomics study (phosphorylation, glycosation, acetylation and so on), biotechnology and signaling pathway analysis are briefly described. Finally, the future developments, applications and outlook of SRM technology are described.
- selective reaction monitoring (SRM),
- proteomics,
- quantification,
- review
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