Citation: CHEN Ping, CHEN Yimin, CHEN Jia, TONG Hongbin, XU Zhiliang. Exploration of toxicity reducing mechanism of aconite alkaloids during decoction process using liquid chromatography-mass spectrometry[J]. Chinese Journal of Chromatography, ;2013, 31(11): 1087-1092. doi: 10.3724/SP.J.1123.2013.05042 shu

Exploration of toxicity reducing mechanism of aconite alkaloids during decoction process using liquid chromatography-mass spectrometry

CHEN Ping ¹ ,
CHEN Yimin ¹ ,
CHEN Jia ² ,
TONG Hongbin ² ,
XU Zhiliang ^2,3,,

1.
1. Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310006, China;

Corresponding author: XU Zhiliang,
Received Date: 27 May 2013
Available Online: 22 August 2013
Fund Project: 科技部国际科技合作项目(2009DFA41250). (2009DFA41250)

A high performance liquid chromatography-electrospray ionization mass spectrometry method was developed for the determination of aconite alkaloids. It was used to investigate the degradation of alkaloids of Radix Aconiti Lateralis Preparata during decoction. Six alkaline degradation products were identified, and the degradation regularity of diester-diterpenoid alkaloids was confirmed during the test using standards. The dynamic changes of the amount of aconite alkaloids in the decoction of Radix Aconiti Lateralis Preparata were supervised. Along with the increase of decoction time, the concentrations of diester-diterpenoid alkaloids and lipo-alkaloid decreased significantly. The results can provide a scientific basis for the safety use of aconite.
- high performance liquid chromatography-mass spectrometry (HPLC-MS),
- alkaloids,
- Radix Aconiti Lateralis Preparata,
- decoction,
- toxicity reducing mechanism
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