Citation: LIN Shanshan, YI Qitong, HONG Jiajun, CHEN Meng, YUAN Dongxing. Matrix effect and retention efficiency of hydrophilic-lipophilic balance cartridges in multi-residual determination of veterinary drugs in river water[J]. Chinese Journal of Chromatography, ;2013, 31(10): 980-988. doi: 10.3724/SP.J.1123.2013.04043 shu

Matrix effect and retention efficiency of hydrophilic-lipophilic balance cartridges in multi-residual determination of veterinary drugs in river water

1.
Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies, College of the Environment and Ecology, Xiamen University, Xiamen 361005, China

Corresponding author: CHEN Meng,
Received Date: 24 April 2013
Available Online: 27 May 2013
Fund Project: 福建省自然科学基金项目(2012J01048) (2012J01048)中国科学院城市环境研究所开放基金项目(KLUEH201009). (KLUEH201009)

Matrix effect is an important interfering factor in LC-MS quantitative analysis. In this paper, matrix effects and retention efficiencies of 33 veterinary drugs spiked in river water were studied on hydrophilic-lipophilic balance (HLB) cartridges of 3 brands (Waters, Supelco, and CNW), using LC-MS/MS for detection and reverse osmosis (RO) water as the control under 500-fold concentration. In RO water, only the exogenous matrix effects were observed on three brands of HLB cartridges. Most quinolones and tetracyclines showed positive matrix effects. Estrogens showed negative matrix effects on two brands of HLB cartridges. Sulfonamides were not obviously affected by matrix effects. Chloramphenicols showed negative matrix effects on one brand of HLB cartridge. In river water, matrix effects were different from those of the RO water due to the combined exogenous and endogenous interfering substances. Sulfonamides showed slight matrix effects as those in RO water. Most quinolones and tetracyclines showed positive matrix effects. Chloramphenicols and estrogens showed negative matrix effects. Compared to the external standard method, matrix matched calibration method effectively overcame the matrix effects with better quantitative results. The recoveries of 33 target veterinary drugs spiked in river water at 50 ng/L and 200 ng/L levels were in the ranges of 40.3%-146.0% (Waters), 37.8%-104.2% (Supelco), and 52.9%-150.1% (CNW) with RSDs (n=4) of 0.2%-14.6%. The results indicated that there was no significant difference in the retention efficiency between the 3 HLB cartridges with the matrix matched calibration method. This study provided supporting data for the HLB cartridge selection in multi-residual determination of the veterinary drugs in river water samples.
- hydrophilic-lipophilic balance (HLB) cartridges,
- liquid chromatography-mass spectrometry,
- veterinary drug,
- river water,
- matrix effect,
- retention efficiency
1. [1]
  [1] Seifrtova M, Pena A, Lino C M, et al. Anal Bioanal Chem, 2008, 391: 799
2. [2]
  [2] Benito-Pea E, Partal-Rodera A I, León-González M E, et al. Anal Chim Acta, 2006, 556: 415
3. [3]
  [3] Batt A L, Aga D S. Anal Chem, 2005, 77: 2940
4. [4]
  [4] Hilton M J, Thomas K V. J Chromatogr A, 2003, 1015: 129
5. [5]
  [5] Reverte S, Borrull F, Pocurull E, et al. J Chromatogr A, 2003, 1010: 225
6. [6]
  [6] Liu H, Zhang G P, Liu C Q. Chinese Journal of Analytical Chemistry (刘虹, 张国平, 刘丛强. 分析化学), 2007, 35(3): 315
7. [7]
  [7] Kasprzyk-Horden B, Dinsdale R M, Guwy A J. J Chromatogr A, 2007, 1161: 132
8. [8]
  [8] Mitani K, Kataoka H. Anal Chim Acta, 2006, 562: 16
9. [9]
  [9] Gao L H, Shi Y L, Li W H, et al. Chinese Journal of Chromatography (高立红, 史亚利, 厉文辉, 等. 色谱), 2010, 28(5): 491
10. [10]
  [10] Sun G D, Su Z Y, Chen M. Chinese Journal of Chromatography (孙广大, 苏仲毅, 陈猛. 色谱), 2009, 27(1): 54
11. [11]
  [11] Hong L J, Shi L, Zhang Y L, et al. Environmental Science (洪蕾洁, 石璐, 张亚雷, 等. 环境科学), 2012, 33(2): 652
12. [12]
  [12] Huang Q T, Chen M, Yuan D X, et al. Journal of Xiamen University: Natural Science (黄群腾, 陈猛, 袁东星, 等. 厦门大学学报: 自然科学版), 2007, 46(1): 77
13. [13]
  [13] Yang C Q, Wang L X, Hou X H, et al. Chinese Journal of Chromatography (杨常青, 王龙星, 侯晓红, 等. 色谱), 2012, 30(8): 756
14. [14]
  [14] Hirsch R, Ternes T A, Haberer K, et al. J Chromatogr A,1998, 815: 213
15. [15]
  [15] Chen C Y, Wen T Y, Wang G S, et al. Sci Total Environ, 2007, 378: 352
16. [16]
  [16] Wang L Q, He L M, Zeng Z L, et al. Journal of Chinese Mass Spectrometry Society (王立琦, 贺利民, 曾振灵, 等. 质谱学报), 2011, 32(6): 321
17. [17]
  [17] US EPA. Method 1694: 2007
18. [18]
  [18] Lu W Q. [MS Dissertation]. Xiamen: Xiamen University (陆婉清. [硕士学位论文]. 厦门: 厦门大学), 2010
19. [19]
  [19] Su Z Y. [MS Dissertation]. Xiamen: Xiamen University (苏仲毅. [硕士学位论文]. 厦门: 厦门大学), 2008
20. [20]
  [20] Trufelli H, Palma P, Famiglini G, et al. Mass Spectrom Rev, 2011, 30: 491
21. [21]
  [21] Kebarle P, Tang L. Anal Chem, 1993, 65: 972A
22. [22]
  [22] King R C, Bonfiglio R, Fernandez-Metzler C, et al. J Am Soc Mass Spectrom, 2000, 11: 942
23. [23]
  [23] Cech N B, Enke C G. Anal Chem, 2000, 72: 2717
24. [24]
  [24] Zhou S, Cook K D. J Am Soc Mass Spectrom, 2001, 12: 206
25. [25]
  [25] Wu J M, Qian X Q, Yang Z G, et al. J Chromatogr A, 2010, 1217: 1471
1. [1]
  Zian Lin , Yingxue Jin . Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) for Disease Marker Screening and Identification: A Comprehensive Experiment Teaching Reform in Instrumental Analysis. University Chemistry, 2024, 39(11): 327-334. doi: 10.12461/PKU.DXHX202403066
2. [2]
  Yanhui Zhong , Ran Wang , Zian Lin . Analysis of Halogenated Quinone Compounds in Environmental Water by Dispersive Solid-Phase Extraction with Liquid Chromatography-Triple Quadrupole Mass Spectrometry. University Chemistry, 2024, 39(11): 296-303. doi: 10.12461/PKU.DXHX202402017
3. [3]
  Zunxiang Zeng , Yuling Hu , Yufei Hu , Hua Xiao . Analysis of Plant Essential Oils by Supercritical CO₂Extraction with Gas Chromatography-Mass Spectrometry: An Instrumental Analysis Comprehensive Experiment Teaching Reform. University Chemistry, 2024, 39(3): 274-282. doi: 10.3866/PKU.DXHX202309069
4. [4]
  Mingyang Men , Jinghua Wu , Gaozhan Liu , Jing Zhang , Nini Zhang , Xiayin Yao . 液相法制备硫化物固体电解质及其在全固态锂电池中的应用. Acta Physico-Chimica Sinica, 2025, 41(1): 2309019-. doi: 10.3866/PKU.WHXB202309019
5. [5]
  Wentao Lin , Wenfeng Wang , Yaofeng Yuan , Chunfa Xu . Concerted Nucleophilic Aromatic Substitution Reactions. University Chemistry, 2024, 39(6): 226-230. doi: 10.3866/PKU.DXHX202310095
6. [6]
  Xiaowu Zhang , Pai Liu , Qishen Huang , Shufeng Pang , Zhiming Gao , Yunhong Zhang . Acid-Base Dissociation Equilibrium in Multiphase System: Effect of Gas. University Chemistry, 2024, 39(4): 387-394. doi: 10.3866/PKU.DXHX202310021
7. [7]
  Lei Shi . Nucleophilicity and Electrophilicity of Radicals. University Chemistry, 2024, 39(11): 131-135. doi: 10.3866/PKU.DXHX202402018
8. [8]
  Chongjing Liu , Yujian Xia , Pengjun Zhang , Shiqiang Wei , Dengfeng Cao , Beibei Sheng , Yongheng Chu , Shuangming Chen , Li Song , Xiaosong Liu . Understanding Solid-Gas and Solid-Liquid Interfaces through Near Ambient Pressure X-Ray Photoelectron Spectroscopy. Acta Physico-Chimica Sinica, 2025, 41(2): 100013-. doi: 10.3866/PKU.WHXB202309036
9. [9]
  Yue Zhao , Yanfei Li , Tao Xiong . Copper Hydride-Catalyzed Nucleophilic Additions of Unsaturated Hydrocarbons to Aldehydes and Ketones. University Chemistry, 2024, 39(4): 280-285. doi: 10.3866/PKU.DXHX202309001
10. [10]
  Daojuan Cheng , Fang Fang . Exploration and Implementation of Science-Education Integration in Organic Chemistry Teaching for Pharmacy Majors: A Case Study on Nucleophilic Substitution Reactions of Alkyl Halides. University Chemistry, 2024, 39(11): 72-78. doi: 10.12461/PKU.DXHX202403105
11. [11]
  Weina Wang , Lixia Feng , Fengyi Liu , Wenliang Wang . Computational Chemistry Experiments in Facilitating the Study of Organic Reaction Mechanism: A Case Study of Electrophilic Addition of HCl to Asymmetric Alkenes. University Chemistry, 2025, 40(3): 206-214. doi: 10.12461/PKU.DXHX202407022
12. [12]
  .
  南开大学师唯/华北电力大学（保定）刘景维：二维配位聚合物中有序的亲锂冠醚位点用于无枝晶锂沉积
  . CCS Chemistry, 2025, 7(0): -.
13. [13]
  Shipeng WANG , Shangyu XIE , Luxian LIANG , Xuehong WANG , Jie WEI , Deqiang WANG . Piezoelectric effect of Mn, Bi co-doped sodium niobate for promoting cell proliferation and bacteriostasis. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1919-1931. doi: 10.11862/CJIC.20240094
14. [14]
  Yaling Chen . Basic Theory and Competitive Exam Analysis of Dynamic Isotope Effect. University Chemistry, 2024, 39(8): 403-410. doi: 10.3866/PKU.DXHX202311093
15. [15]
  YanYuan Jia , Rong Rong , Jie Liu , Jing Guo , GuoYu Jiang , Shuo Guo . Unity is Strength, and Independence Shines: A Science Popularization Experiment on AIE and ACQ Effects. University Chemistry, 2024, 39(9): 349-358. doi: 10.12461/PKU.DXHX202402035
16. [16]
  Xingyuan Lu , Yutao Yao , Junjing Gu , Peifeng Su . Energy Decomposition Analysis and Its Application in the Many-Body Effect of Water Clusters. University Chemistry, 2025, 40(3): 100-107. doi: 10.12461/PKU.DXHX202405074
17. [17]
  Supin Zhao , Jing Xie . Understanding the Vibrational Stark Effect of Water Molecules Using Quantum Chemistry Calculations. University Chemistry, 2025, 40(3): 178-185. doi: 10.12461/PKU.DXHX202406024
18. [18]
  Yaqin Zheng , Lian Zhuo , Meng Li , Chunying Rong . Enhancing Understanding of the Electronic Effect of Substituents on Benzene Rings Using Quantum Chemistry Calculations. University Chemistry, 2025, 40(3): 193-198. doi: 10.12461/PKU.DXHX202406119
19. [19]
  Xiaotian ZHU , Fangding HUANG , Wenchang ZHU , Jianqing ZHAO . Layered oxide cathode for sodium-ion batteries: Surface and interface modification and suppressed gas generation effect. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 254-266. doi: 10.11862/CJIC.20240260
20. [20]
  Ying Zhang , Fang Ge , Zhimin Luo . AI-Driven Biochemical Teaching Research: Predicting the Functional Effects of Gene Mutations. University Chemistry, 2025, 40(3): 277-284. doi: 10.12461/PKU.DXHX202412104

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(199)
HTML views(3)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Matrix effect and retention efficiency of hydrophilic-lipophilic balance cartridges in multi-residual determination of veterinary drugs in river water

南开大学师唯/华北电力大学（保定）刘景维：二维配位聚合物中有序的亲锂冠醚位点用于无枝晶锂沉积

Metrics

通讯作者: 陈斌, bchen63@163.com