Citation: FENG Yuechao, JIA Li, HE Yahui, WANG Jianfeng, LIU Yan, FAN Xiaojing. Simultaneous determination of 24 industrial dyes in grain and meat products by ultra performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2013, 31(10): 1021-1027. doi: 10.3724/SP.J.1123.2013.03019 shu

Simultaneous determination of 24 industrial dyes in grain and meat products by ultra performance liquid chromatography-tandem mass spectrometry

1.
Beijing Centre for Physical and Chemical Analysis, Beijing Engineering Research Center of Food Safety Analysis, Beijing 100089, China

Corresponding author: JIA Li,
Received Date: 7 March 2013
Available Online: 26 April 2013
Fund Project: 北京市科技专项项目(Z111106055311093). (Z111106055311093)

An ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analytical method was established for the simultaneous determination of 24 forbidden industrial dyes in grain and meat products. The sample was extracted with methanol and acetonitrile, and cleaned-up by a WAX solid phase extraction column. The solution was separated on an ACQUITY UPLC BEH C18 column eluted with a mixture of 10 mmol/L ammonium acetate-0.2%formic acid aqueous solution and methanol-acetonitrile (7:3, v/v) as the mobile phases, and then analyzed in multiple reaction monitoring (MRM) mode. The correlation coefficients were above 0.99, the average recoveries were 61%-116%, and the relative standard deviations (RSD, n=6) were lower than 13%. The quantification limits were 0.1-4.0 μg/kg. This method is simple, effective, sensitive, and suitable for the determination and confirmation of the 24 forbidden industrial dyes in grain and meat products.
- ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS),
- solid phase extraction (SPE),
- industrial dyes,
- grain,
- meat products
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沈阳化工大学材料科学与工程学院沈阳 110142