Citation: ZHU Feng, LIU Hualiang, CHEN Bei, RONG Weiguang, MA Yongjian. Rapid simultaneous screening and detection of ten anticoagulant rodenticides in foods by ultra-high performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2013, 31(5): 473-476. doi: 10.3724/SP.J.1123.2012.11026 shu

Rapid simultaneous screening and detection of ten anticoagulant rodenticides in foods by ultra-high performance liquid chromatography-tandem mass spectrometry

1.
Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China

Corresponding author: LIU Hualiang,
Received Date: 28 November 2012
Available Online: 24 January 2013
Fund Project: 卫生部公益性行业科研专项项目(200902009) (200902009)江苏省科技厅科技支撑计划项目(BE2010745) (BE2010745)江苏省"十二五"科教兴卫工程项目(ZX201109). (ZX201109)

A rapid method for the simultaneous screening and detection of ten anticoagulant rodenticides in foods was developed by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). After the extraction by acetonitrile and clean-up by QuEChERS, the extract was separated on a Poroshell 120 EC-C18 column (100 mm×2.1 mm, 2.7 μm) with the gradient elution of 5 mmol/L ammonium acetate and acetonitrile. The detection was carried out by UPLC-MS/MS using a negative electrospray ionization interface in multiple reaction monitoring (MRM) mode. The ten anticoagulant rodenticides showed a good linear relationship (r>0.99) in the range of 5-500 μg/L. In the four samples of chili sauce, flour, vinegar and soy sauce, the spiked recoveries were in the range of 72.6%-112%, and the relative standard deviations (RSD) were all not more than 11.2%. The limits of detection (LOD) were all in the range of 0.5-4.5 μg/kg. This method is rapid, simple, sensitive, accurate and of good specificity for the satisfactory rapid screening and detection of the ten anticoagulant rodenticides in the sudden public health security events.
- ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS),
- anticoagulant rodenticides,
- foods
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沈阳化工大学材料科学与工程学院沈阳 110142