Citation: WANG Yan-Song, HE Ming-Rui, ZHANG Chun-Ye, FAN Shi-Hua, MA Ji, LI Hua-Feng. Determination of Multiresidual Fungicides in Environmental Water Samples by High Performance Liquid Chromatography Tandem Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2012, 40(11): 1764-1771. doi: 10.3724/SP.J.1096.2012.20100 shu

Determination of Multiresidual Fungicides in Environmental Water Samples by High Performance Liquid Chromatography Tandem Mass Spectrometry

1.
¹ College of Sciences, Northeastern University, Shenyang 110004, China;

Corresponding author: WANG Yan-Song,
Received Date: 9 February 2012
Available Online: 3 May 2012

A sensitive multiresidual analytical method for simultaneous analysis of multiresidual fungicides in environmental water samples was developed. The method was based on solid phase extraction (SPE) followed by high performance liquid chromatography tandem mass spectrometry (LC-MS/MS). Qualitative and quantitative detection for the analytes was carried out under the multiple reaction monitoring (MRM) in positive ionization mode after chromatography separation. In this method we have studied the conversion rule, identified the chromatogram retention time of Z-isomer and E-isomer of flumorph and dimethomorph, confirmed their chromatographic behavior by monitoring concentrations of two isomers of them at room temperature under sunlight and optimized parameters that may affect the SPE procedure efficiency: the column type, the wash solvent and the elution solvent. The recoveries of the SPE gave levels ranged from 70.18% to 108.87%, all recoveries were acceptable, with relative standard deviation (RSD) ≤16.7%. The limit of quantification (LOQ, S/N=10) varied between 0.003 and 0.03 μg/L (except for fenhexamid 0.3 μg/L). The developed method was applied for the determination of multiresidual fungicides in 100 tap water samples and 6 environmental samples collected from Liaoning province in China. Total fungicides were not found in tap water samples. Azoxystrobin (0.051 μg/L), metalaxyl (0.217 μg/L) and dimethomorph (Z, E) (0.015 μg/L) were found in Pu river sample, dimethomorph (Z, E) (0.004 μg/L) was found in Hun river sample, the highest concentration level of metalaxyl was 0.217 μg/L in Pu river, the rest of fungicides remained undetected in river samples.
- Liquid chromatography-tandem mass spectrometry,
- Multiresidual fungicides,
- Solid phase extratione,
- Modifier,
- Environmental water
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沈阳化工大学材料科学与工程学院沈阳 110142