Citation: WANG Xiao-Yu, WEI Hui. Advance in Peroxidase-like Nanozymes and Their Analytical Applications[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(5): 666-680. doi: 10.19756/j.issn.0253-3820.231056 shu

Advance in Peroxidase-like Nanozymes and Their Analytical Applications

WANG Xiao-Yu ^1,2,, ,
WEI Hui ^2,,

1.
Department of Chemistry and Material Science, College of Science, Nanjing Forestry University, Nanjing 210037, China;
2.
Jiangsu Key Laboratory of Artificial Functional Materials, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210023, China

Corresponding author: WANG Xiao-Yu, WEI Hui,
Received Date: 17 February 2023
Revised Date: 19 April 2023

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 22104055, 21874067, 21722503), the National Key R&D Program of China (Nos. 2021YFF1200700, 2019YFA0709200), the Priority Academic Program Development Jiangsu Higher Education Institutions Program and the Fundamental Research Funds for the Central Universities of China (Nos. 202200325, 021314380195).

Among different nanozymes, peroxidase-like nanozymes have attracted extensive attention because of their great prospects in biosensing, bioimaging and disease treatment. By combining experiments with computational studies, several reports have elucidated the catalytic mechanism and structure-activity relationship of peroxidase-like nanozymes. Furthermore, to enable the rational design of highly active peroxidase-like nanozymes, several pioneering studies have developed numerous descriptors that can be used to predict their catalytic activity. These rationally designed highly active nanozymes have been used for in vitro and in vivo assays. This review first focused on the progress in the rational design of peroxidase-like nanozymes, and then introduced some typical examples of the analytical applications of peroxidase-like nanozymes. In addition, the key issues and challenges faced by peroxidase-like nanozymes were summarized and their further development directions were prospected.
- Nanozymes,
- Peroxidase,
- Catalytic mechanisms,
- Analytical applications,
- Rational design,
- Review
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