Citation: YANG Pu, FANG Hao, MENG Zi-Wei, ZHENG Ling-Na, WANG Bing, WANG Meng, LIU Guang-Cai, CHENG Wen-Bo, FENG Wei-Yue. Determination of Metal-doped Microplastic in Biological Samples by Single Particle-Inductively Coupled Plasma Time-of-Flight Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(6): 1059-1065. doi: 10.19756/j.issn.0253-3820.231035 shu

Determination of Metal-doped Microplastic in Biological Samples by Single Particle-Inductively Coupled Plasma Time-of-Flight Mass Spectrometry

YANG Pu ^1,2 ,
FANG Hao ^1,2 ,
MENG Zi-Wei ¹ ,
ZHENG Ling-Na ¹ ,
WANG Bing ¹ ,
WANG Meng ^1,, ,
LIU Guang-Cai ³ ,
CHENG Wen-Bo ^3,, ,
FENG Wei-Yue ¹

1.
Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China;
3.
Tianjin Key Laboratory of Medical Mass Spectrometry for Accurate Diagnosis, Tianjin Engineering Technology Research Branch, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Tianjin 300399, China

Corresponding author: WANG Meng, CHENG Wen-Bo,
Received Date: 4 February 2023
Revised Date: 26 April 2023

Fund Project: Supported by the Guangdong Basic and Applied Basic Research Fund (No. DG2231351B), the State Key Laboratory of Environmental Chemistry and Ecotoxicology (No. KF2020-19) and the Tianjin Key Laboratory of Medical Mass Spectrometry for Accurate Diagnosis.

A new method for analysis of metal-doped polystyrene microplastics in biological samples by single particle-inductively coupled plasma time-of-flight mass spectrometry (SP-ICP-TOF-MS) was developed. Mouse liver samples spiked with the particles were successfully digested using tetramethylammonium hydroxide and hydrogen peroxide. Centrifugal concentration method was used to remove the matrix from the digested solution and to meet the analytical requirements of SP-ICP-TOF-MS. The method achieved recoveries of 102%±11% for microplastic particles. The SP-ICP-TOF-MS achieved detection limits of 0.004-0.026 fg for Ce, Eu, Ho, and Lu in microplastics, and 37 particles/mL for particle number concentration. The developed method provided a new approach to study the environmental impact and toxicology of microplastics.
- Microplastics,
- Inductively coupled plasma time-of-flight mass spectrometry,
- Single particle analysis
1. [1]
  KOELMANS A A, BESSELING E, FOEKEMA E, KOOI M, MINTENIG S, OSSENDORP B C, REDONDOHASSELERHARM P E, VERSCHOOR A, VAN WEZEL A P, SCHEFFER M. Environ. Sci. Technol., 2017, 51(20):11513-11519.
2. [2]
  HARTMANN N B, HÜFFER T, THOMPSON R C, HASSELLÖV M, VERSCHOOR A, DAUGAARD A E, RIST S, KARLSSON T, BRENNHOLT N, COLE M, HERRLING M P, HESS M C, IVLEVA N P, LUSHER A L, WAGNER M. Environ. Sci. Technol., 2019, 53(3):1039-1047.
3. [3]
  NOR N H M, KOOI M, DIEPENS N J, KOELMANS A A. Environ. Sci. Technol., 2021, 55(8):5084-5096.
4. [4]
  SCHWABL P, KÖPPEL S, KÖNIGSHOFER P, BUCSICS T, TRAUNER M, REIBERGER T, LIEBMANN B. Ann. Intern. Med., 2019, 171(7):453-457.
5. [5]
  RAGUSA A, SVELATO A, SANTACROCE C, CATALANO P, NOTARSTEFANO V, CARNEVALI O, PAPA F, RONGIOLETTI M C A, BAIOCCO F, DRAGHI S, D'AMORE E, RINALDO D, MATTA M, GIORGINI E. Environ. Int., 2021, 146:106274.
6. [6]
  LEHNER R, WEDER C, PETRI-FINK A, ROTHEN-RUTISHAUSER B. Environ. Sci. Technol., 2019, 53(4):1748-1765.
7. [7]
  CAI H, XU E G, DU F, LI R, LIU J, SHI H. Chem. Eng. J., 2021, 410:128208.
8. [8]
  DAVRANCHE M, LORY C, JUGE C L, BLANCHO F, DIA A, GRASSL B, EL HADRI H, PASCAL P Y, GIGAULT J. Nanoimpact, 2020, 20:100262.
9. [9]
  LI X, CHEN L, MEI Q, DONG B, DAI X, DING G, ZENG E Y. Water Res., 2018, 142:75-85.
10. [10]
  JENNER L C, ROTCHELL J M, BENNETT R T, COWEN M, TENTZERIS V, SADOFSKY L R. Sci. Total Environ., 2022, 831:154907.
11. [11]
  KENNEDY A J, HULL M S, DIAMOND S, CHAPPELL M, BEDNAR A J, LAIRD J G, MELBY N L, STEEVENS J A. Environ. Sci. Technol., 2015, 49(20):12490-12499.
12. [12]
  POMPA P P, VECCHIO G, GALEONE A, BRUNETTI V, MAIORANO G, SABELLA S, CINGOLANI R. Nanoscale, 2011, 3(7):2889-2897.
13. [13]
  WITTMAACK K. Environ. Health Persp., 2007, 115(2):187-194.
14. [14]
  SCHWERTFEGER D M, VELICOGNA J R, JESMER A H, SCROGGINS R P, PRINCZ J I. Anal. Chem., 2016, 88(20):9908-9914.
15. [15]
16. [16]
17. [17]
  LABORDA F, TRUJILLO C, LOBINSKI R. Talanta, 2021, 221:121486.
18. [18]
  JIMENEZ-LAMANA J, MARIGLIANO L, ALLOUCHE J, GRASSL B, SZPUNAR J, REYNAUD S. Anal. Chem., 2020, 92(17):11664-11672.
19. [19]
  MITRANO D M, BELTZUNG A, FREHLAND S, SCHMIEDGRUBER M, CINGOLANI A, SCHMIDT F. Nat. Nanotechnol., 2019, 14(4):362-368.
20. [20]
  ENDERS K, LENZ R, BEER S, STEDMON C A. ICES J. Mar. Sci. 2017, 74(1):326-331.
21. [21]
  CHANG P P, ZHENG L N, WANG B, CHEN M L, WANG M, WANG J H, FENG W Y. At. Spectrosc., 2022, 43(3):255-265.
22. [22]
  TIAN X, JIANG H, HU L, WANG M, CUI W, SHI J, LIU G, YIN Y, CAI Y, JIANG G. TrAC, Trends Anal. Chem., 2022, 157:116746.
23. [23]
24. [24]
25. [25]
  MONTANO M D, OLESIK J W, BARBER A G, CHALLIS K, RANVILLE J F. Anal. Bioanal. Chem., 2016, 408(19):5053- 5074.
26. [26]
  MERRIFIELD R C, STEPHAN C, LEAD J R. Environ. Sci. Technol., 2018, 52(4):2271-2277.
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