Citation: MA Xiao, ZHAO Dan, WU Pei-Cheng, LIN Ji-Hong, WANG Fang, XU Yan-Jie, HE Long-Long, LIU Xin-Yu, SUN Jian. Metal-Organic Framework-based Nanozymes and Their Applications in Bioanalysis[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(6): 922-933. doi: 10.19756/j.issn.0253-3820.221625 shu

Metal-Organic Framework-based Nanozymes and Their Applications in Bioanalysis

MA Xiao ¹ ,
ZHAO Dan ^1,, ,
WU Pei-Cheng ¹ ,
LIN Ji-Hong ¹ ,
WANG Fang ¹ ,
XU Yan-Jie ¹ ,
HE Long-Long ¹ ,
LIU Xin-Yu ² ,
SUN Jian ^,

1.
Department of Environmental Engineering and Chemistry, Luoyang Institute of Science and Technology, Luoyang 471023, China;
2.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Corresponding author: ZHAO Dan, SUN Jian,
Received Date: 18 December 2022
Revised Date: 15 February 2023

Fund Project: Supported by the Henan Provincial Science and Technology Plan Project-Science and Technology Research Project (No. 212102210122), the National Natural Science Foundation of China (Nos. 22104046), the Henan Provincial Department of Education Key Project (Nos. 23A150056, 23A530007) and the Luoyang Institute of Science and Technology High-level Talents Startup Project (No. 2019BZ18).

Nanozymes, as a class of nanomaterials with enzyme-like activity, exhibit good development and application potential in the fields of analytical chemistry and disease diagnosis and treatment. Metal-organic frameworks (MOFs) materials are porous crystalline materials formed by metal nodes and organic ligands, and their structures have certain similarities with natural enzymes. At present, researchers have developed a variety of nanozymes based on MOFs, including nanozymes with peroxidase-like, oxidase-like, superoxide dismutase-like, and hydrolase-like activities, showing broad application prospects. In this paper, according to the structural characteristics of the materials, MOFs-based nanozymes were divided into four categories, including original MOFs, chemically modified MOFs, MOFs composite materials and MOFs derivatives, and the basic principles and latest developments in the preparation of these nanozymes were introduced. Based on analytical strategies such as colorimetric sensing, fluorescent sensing and electrochemical sensing, the application progress of MOFs-based nanozymes in bioanalysis was reviewed. The challenges of their practical applications and future development trends were also discussed.
- Metal-organic frameworks,
- Nanozyme,
- Colorimetric sensing,
- Fluorescent sensing,
- Electrochemical sensing,
- Review
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