Citation: GAO Jing, ZHAO Guan-Fang, LIU Chao, LI Hong-Ru, YU Yang, ZHANG Tao, WANG Hong-Da. Biomembranomics at Molecular Level: A New Generation of Biomics[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(5): 721-732. doi: 10.19756/j.issn.0253-3820.221601 shu

Biomembranomics at Molecular Level: A New Generation of Biomics

GAO Jing ¹ ,
ZHAO Guan-Fang ¹ ,
LIU Chao ^1,2 ,
LI Hong-Ru ^1,2 ,
YU Yang ^1,2 ,
ZHANG Tao ^1,2 ,
WANG Hong-Da ^1,2,,

1.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2.
University of Science and Technology of China, Hefei 230026, China

Corresponding author: WANG Hong-Da, hdwang@ciac.ac.cn
Received Date: 6 December 2022
Revised Date: 11 January 2023

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 22150003, 21727816, 21721003) and the Scientific Instrument Developing Project of Chinese Academy of Sciences (No. ZDKYYQ20220005).

Biomics is an important research means to reveal the laws of life and human health. However, it is essentially a large-scale feature study at the overall level, and cannot be directly used for disease diagnosis and treatment. Therefore, it is urgent to establish a new omics system to study the structure, location, orderly interaction and dynamic function of biomolecules at the molecular level. As the basic unit of life structure, cells are defined by biomembranes. The biomembranes form an important barrier between living cells and the surrounding environment, and separate organelles in eukaryotic cells. The study of membrane structure has a history of nearly one hundred years. Although many models of cell membrane structure have been proposed, they are still in the stage of model hypothesis. Because the structure, function and interaction between membrane components are indivisible organic whole, the research on one aspect alone cannot uncover the biomembrane system in essence. Based on this, this paper proposed a new concept of ″biomembromics″, which regarded the structure, function and intermolecular interaction of membrane system as an organic whole, and established a new and real membrane structure at the molecular level. In addition, the latest progress in the researches of membrane structure, properties and functions at the molecular level were summarized. Finally, the development trend, opportunities and challenges of biomembranomics were discussed.
- Biomembrane,
- Biomembranomics,
- Membrane proteins,
- Membrane structure,
- Membrane functions,
- Review
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