Citation: TIAN Ye, GAO Li-Li, ZHANG Wei, LOU Bao-Hua, GUAN Yi-Ran, XU Guo-Bao. Recent Advances in Electrochemistry Assays of Diabetic Kidney Disease Biomarkers[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(5): 744-756. doi: 10.19756/j.issn.0253-3820.221594 shu

Recent Advances in Electrochemistry Assays of Diabetic Kidney Disease Biomarkers

TIAN Ye ^1,, ,
GAO Li-Li ² ,
ZHANG Wei ^3,4 ,
LOU Bao-Hua ³ ,
GUAN Yi-Ran ³ ,
XU Guo-Bao ^3,4,,

1.
The College of Civil Engineering, Shenyang Urban Construction University, Shenyang 110167, China;
2.
School of Materials Science and Engineering, Shenyang Jianzhu University, Shenyang 110168, China;
3.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
4.
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China

Corresponding author: TIAN Ye, XU Guo-Bao,
Received Date: 2 December 2022
Revised Date: 9 March 2023

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 22174136, 22004116).

Diabetic kidney disease (DKD) is the microvascular disease of the glomeruli and renal tubules as a result of diabetes. It is one of the most frequent and serious chronic complications of diabetes. The early stage of DKD has a certain occult and the clinical symptoms appear late. It has a certain concealment in the early stage and it is often more difficult to treat than other renal diseases. Therefore, the early detection of DKD biomarker is of great significance to reduce renal damage. However, there is no single indicator for early diagnosis of DKD. The combination of multiple indicators and symptoms are used in its clinical diagnosis. Hence, the establishment of simple, efficient and sensitive multi-biomarker detection platforms for the early diagnosis of DKD is much demanded. In this review, taking different types of DKD biomarkers (microRNAs, cystatin C, homocysteine, creatinine, type IV collagen, and n-acetylglucosaminidase) as examples, a comprehensive summary of the recent developments of various types of electrochemical detection platforms was presented for them over recent years, such as electrochemistry (EC) and electrogenerated chemiluminescence (ECL), and its further development was prospected.
- Diabetic kidney disease,
- Biomarkers,
- Electrochemistry,
- Electrochemiluminescence,
- Review
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