Citation: YAN Meng-Hua, YANG Gao-Xia, WANG Guang-Li. Enhanced and Homogeneous Cathodic Photoelectrochemical Analysis Based on Surface Passivation Effect[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(2): 276-286. doi: 10.19756/j.issn.0253-3820.221494 shu

Enhanced and Homogeneous Cathodic Photoelectrochemical Analysis Based on Surface Passivation Effect

Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China

Corresponding author: WANG Guang-Li, glwang@jiangnan.edu.cn
Received Date: 6 October 2022
Revised Date: 1 December 2022

Fund Project: Supported by the National Natural Science Foundation of China (No.22174054).

Homogeneous and split-type photoelectrochemical (PEC) sensors based on the enhancement effect of Cd²⁺ on the photocurrent of lead selenide quantum dots (PbSe QDs) were constructed for sensitive detection of miRNA-21 and carcinoembryonic antigen (CEA). The detection method used the hairpin DNA assembly by T-Hg²⁺-T base mismatch, whose loops were combined with miRNA-21 or the complementary strand of CEA aptamer to form double strands. Signal amplification was carried out by non-enzymatic DNA strand displacement reaction to release Hg²⁺ in the hairpin structure, and then the released Hg²⁺ exchanged ions with cadmium sulfide quantum dots (CdS QDs) to release Cd²⁺. Then, Cd²⁺ reacted with PbSe QDs modified electrode to form cadmium selenide (CdSe) layer on its surface, which eliminated the electron-hole recombination center on the surface and improved the charge separation efficiency, realizing enhanced photocurrent output. The experimental results showed that the linear range for detection of miRNA-21 was 5.0×10^-16-5.0×10^-10 mol/L, and the detection limit was 6.8×10^-17 mol/L (S/N = 3). The logarithm of the concentration of CEA was linear with the photocurrent in the range of 5.0×10^-2-5.0×10⁴ pg/mL, and the detection limit was 0.007 pg/mL (S/N = 3). The developed PEC biosensors showed good selectivity and could be used for detection of real samples with satisfactory results.
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