Citation: WU Jin-Dan, CAO Ying-Zi, CHEN Kai-Xin, ZHA Yong-Chao, LIU Hong-Shen, ZHOU Ping, LI Nan. Mannich Reaction Based Aggregation-induced Emission for Fluorescent Sensitive Detection of Formaldehyde[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(2): 194-203. doi: 10.19756/j.issn.0253-3820.221482 shu

Mannich Reaction Based Aggregation-induced Emission for Fluorescent Sensitive Detection of Formaldehyde

Key Laboratory of Biomaterials of College of Guangdong Province, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China

Corresponding author: LI Nan, linanbie@jnu.edu.cn
Received Date: 28 September 2022
Revised Date: 23 November 2022

Fund Project: Formaldehyde

Formaldehyde is a kind of colorless and odorless carcinogen that can cause many diseases. It is very necessary to develope a simple and sensitive detection method for formaldehyde in environmental monitoring, toxicological assessment, clinical diagnosis and medical care. Herein, a new fluorescence detection method was developed based on the aggregation-induced emission (AIE) effect for aqueous formaldehyde. An AIE probe of tetra (4-hydroxyphenyl) ethylene (TPE-4OH) was synthesized, which could react with formaldehyde by Mannich reaction in the presence of 1,2,4,5-benzenetetramine tetrahydrochloride (BTA), causing an obvious enhancement of fluorescence of TPE-4OH. Due to the fluorescence enhancement of TPE-4OH related to the Mannich reaction and the concentration of formaldehyde, the detection of formaldehyde in the aqueous solution could be realized by measuring the fluorescence intensity of TPE-4OH. By optimizing the conditions of reactant concentration, solution pH value and reaction time, the linear range of detection of formaldehyde was from 1.0 μmol/L to 2000 μmol/L, and the detection limit was 1.0 μmol/L. The results showed that this method had the potential in sensing/diagnosis applications of formaldehyde.
- Formaldehyde,
- Fluorescent detection,
- Aggregation-induced emission,
- Mannich reaction,
- Molecular probe
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