Citation: FAN Bo, LIU Lan, WU Qian, ZHENG Zi-Liang, XING Yang, ZHANG Juan, ZHANG Rui-Ping. Biomineralization-inspired Synthesis of Lactoferrin-mediated Copper Sulfide Nanoparticle and Its Photothermal Ablation for Tumor Therapy[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(2): 239-249. doi: 10.19756/j.issn.0253-3820.221293 shu

Biomineralization-inspired Synthesis of Lactoferrin-mediated Copper Sulfide Nanoparticle and Its Photothermal Ablation for Tumor Therapy

FAN Bo ^1,2 ,
LIU Lan ¹ ,
WU Qian ¹ ,
ZHENG Zi-Liang ² ,
XING Yang ^1,2 ,
ZHANG Juan ² ,
ZHANG Rui-Ping ^1,2,,

1.
School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China;
2.
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan 030032, China

Corresponding author: ZHANG Rui-Ping, zrp_7142@sxmu.edu.cn
Received Date: 4 June 2022
Revised Date: 14 October 2022

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 82211001138, 82071987, 81771907), the Youth Scientific Research Project of Shanxi Province (No. 20210302124703) and the Foundation for PhD of Shanxi Medical University (No 03201620).

Photothermal agents with strong light absorption in the second near-infrared (NIR-II) region are strongly desired for successful photothermal therapy (PTT). In this work, the lactoferrin-mediated copper sulfide nanoparticles (CuS@Lf NPs) were successfully synthesized by biomineralization strategy. The uniform CuS@Lf NPs showed strong NIR-Ⅱ absorbance in the wavelength range of 1000-1300 nm and possessed high photothermal conversion efficiency, which could be applied in antitumor therapy under 1064 nm laser irradiation. Moreover, lactoferrin (Lf) not only improved the solubility of CuS nanoparticles, but also enhanced their biocompatibility and tumor targeting. Meanwhile, the antioxidant effect of Lf could eliminate oxidative damage after photothermal therapy and reduce tumor recurrence. Herein, the U87 glioma model with high expression of low density lipoprotein receptor associated protein (LRP-1) was used to study the antitumor effects of CuS@Lf NPs in vivo and in vitro. As a result, CuS@Lf NPs displayed effective photothermal tumor ablation, which provided a foundation for NIR-Ⅱ based photothermal therapy in antitumor application.
- Copper sulfide,
- Lactoferrin,
- Second near infrared region,
- Photothermal therapy
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