Citation: ZOU Zhi-Feng, GAO Jing, LAI Yi, XU Zhi-Ai. Tumor-Targeted Theranostic Probe for Near Infrared Ⅱ Window Fluorescence Imaging and Anticancer Therapy of Triple-Negative Breast Cancer[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(6): 912-923. doi: 10.19756/j.issn.0253-3820.221115 shu

Tumor-Targeted Theranostic Probe for Near Infrared Ⅱ Window Fluorescence Imaging and Anticancer Therapy of Triple-Negative Breast Cancer

ZOU Zhi-Feng ^1,2 ,
GAO Jing ² ,
LAI Yi ² ,
XU Zhi-Ai ^1,,

1.
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China;
2.
State Key Laboratory of Drug Research&Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

Corresponding author: XU Zhi-Ai, zaxu@chem.ecnu.edu.cn
Received Date: 8 March 2022
Revised Date: 20 April 2022

Fund Project: Supported by the National Natural Science Foundation of China(No. 22074043).

Donor-acceptor-donor(D-A-D) type fluorescent probes have been widely used in biological imaging due to their excellent optical stability and biocompatibility. By molecular engineering, the fluorescence emission of D-A-D type probe can shift to the near infrared Ⅱ window(NIR-Ⅱ), which shows that the probe has potential for bioimaging and photothermal therapy due to its good photothermal conversion efficiency. However, its large molecular weight leads to unavoidable disadvantages such as poor water solubility, which seriously limits its application. Therefore, in this work, an actively targeted polymer(CRGDK-PEG-b-PLGA) was designed to improve the water-solubility, tumor-specificity and photothermal efficacy of D-A-D type fluorescent probe(TQTCD), thus achieving the integration of diagnosis and treatment. CRGDK-PEG-b-PLGA and TQTCD could self-assemble to form homogeneous and stable nanoparticles(named RPP@TQTCD). This strategy did not affect the fluorescence properties and photothermal effects of TQTCD. CRGDK ligand-modification could increase the tumor accumulation of RPP@TQTCD NPs and interact with the Neuropilin-1(NRP-1) receptor, which was highly expressed on the surface of tumor cells, to promote cellular uptake of RPP@TQTCD NPs through NRP-1-CRGDK pathway.Then, RPP@TQTCD NPs could effectively kill tumor cells under 808 nm laser irradiation in vitro and in vivo. This study provided an effective strategy for the diagnosis and photothermal treatment of triple negative breast cancer(TNBC) through the targeted delivery of hydrophobic probe.
- Active targeting,
- Near infrared Ⅱ region fluorescence,
- Photothermal therapy,
- Theranostic,
- Triple negative breast cancer
1. [1]
  DERAKHSHAN F, REIS-FILHO J S. Annu. Rev. Pathol.:Mech. Dis., 2022, 17:181-204.
2. [2]
  SHAFAEE N M, SINHA A K, SAIGAL B, MURTHY R K, SYED M P, WOODSON A H, ARUN B, BARCENAS C H. J. Clin. Oncol., 2016, 34:1095-1095.
3. [3]
  STEENBRUGGEN T G, VAN RAMSHORST M S, VAN WERKHOVEN E, DEZENTJÉV O, SIESLING S, LINN S C, SONKE G S. J. Clin. Oncol., 2019, 37:536-536.
4. [4]
  GARRIDO-CASTRO A C, BARRY W T, TRAINA T A, WESOLOWSKI R, TUNG N M, KEENAN T, VAN ALLEN E M, LIN N U, WINER E P, KROP L E, TOLANEY S M. J. Clin. Oncol., 2018, 36:TPS1118.
5. [5]
  CHOWDHURY P, GHOSH U, SAMANTA K, JAGGI M, CHAUHAN S C, YALLAPU M M. Bioact. Mater., 2021, 6:3269-3287.
6. [6]
  BIANCHINI G, DE ANGELIS C, LICATA L, GIANNI L. Nat. Rev. Clin. Oncol., 2022, 19:91-113.
7. [7]
  KARJALAINEN K, JAALOUK D E, BUESO-RAMOS C E, ZURITA A J, KUNIYASU A, ECKHARDT B L, MARINI F C, LICHTIGER B, O'BRIEN S, KANTARJIAN H M, CORTES J E, KOIVUNEN E, ARAP W, PASQUALINI R. Blood, 2011, 117:920-927.
8. [8]
  LIU X S, LIN P, PERRETT L, LIN J, LIAO Y P, CHANG C H, JIANG J H, WU N P, DONAHUE T, WAINBERG Z, NEL A E, MENG H. J. Clin. Invest., 2017, 127:2007-2018.
9. [9]
  LI L H, JIANG X, ZHANG Q, DONG X S, GAO Y Q, HE Y L, QIAO H Q, XIE F Y, XIE X J, SUN X Y. J. Exp.Clin. Cancer Res., 2016, 35:16.
10. [10]
  ZHAO P Q, XU Y L, JI W, ZHOU S Y, LI L F, QIU L H, QIAN Z Z, WANG X H, ZHANG H L. J. Nanobiotechnol., 2021, 19:181.
11. [11]
  YANG R Q, WANG P Y, LOU K L, DANG Y Y, TIAN H N, LI Y, GAO Y Y, HUANG W H, ZHANG Y Q, LIU X L, ZHANG G J. Adv. Sci., 2022, 9(12):2104728.
12. [12]
  LI X S, LOVELL J F, YOON J, CHEN X Y. Nat. Rev. Clin. Oncol., 2020, 17:657-674.
13. [13]
  DAI H M, WANG X R, SHAO J J, WANG W J, MOU X Z, DONG X C. Small, 2021, 17:2102646.
14. [14]
  SU Y B, YU B, WANG S, CONG H L, SHEN Y Q. Biomaterials, 2021, 271:120717.
15. [15]
  WANG Z H, SHE M Y, CEHN J, CHENG Z Q, LI J L. Adv. Opt. Mater., 2022, 10:2101634.
16. [16]
  ZHOU F Q, GAO J, TANG Y, ZOU Z F, JIAO S, ZHOU Z C, XU H X, XU Z P, YU H J, XU Z A. Adv. Mater., 2021, 33:2102668.
17. [17]
  ZHU Q R, SUN F, LI T L, ZHOU M X, YE J Y, WANG H, DING C Y, CHEN H, XU Z A, YU H J. Small, 2021, 17:2007882.
18. [18]
  HOU B, ZHOU L, WANG H, SAEED M, WANG D G, XU Z A, LI Y P, YU H J. Adv. Mater., 2020, 32:1907210.
19. [19]
  HESSEL C M, PATTANI V P, RASCH M, PANTHANI M G, KOO B, TUNNELL J W, KORGEL B A. Nano Lett., 2011, 11(6):2560-2566.
20. [20]
  ZHANG J Y, ZHANG X S, LI Z Y, WANG Q S, SHI Y, JIANG X, SUN X Y. Front. Oncol., 2021, 11:654672.
1. [1]
  Jiahui CHEN , Tingting ZHENG , Xiuyun ZHANG , Wei LÜ . Research progress of near-infrared absorption inorganic nanomaterials in photothermal and photodynamic therapy of tumors. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2396-2414. doi: 10.11862/CJIC.20240106
2. [2]
  Peng GENG , Guangcan XIANG , Wen ZHANG , Haichuang LAN , Shuzhang XIAO . Hollow copper sulfide loaded protoporphyrin for photothermal-sonodynamic therapy of cancer cells. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1903-1910. doi: 10.11862/CJIC.20240155
3. [3]
  Qi Wang , Yicong Gao , Feng Lu , Quli Fan . Preparation and Performance Characterization of the Second Near-Infrared Phototheranostic Probe: A New Design and Teaching Practice of Polymer Chemistry Comprehensive Experiment. University Chemistry, 2024, 39(11): 342-349. doi: 10.12461/PKU.DXHX202404141
4. [4]
  Xue Wu , Yupeng Liu , Bingzhe Wang , Lingyun Li , Zhenjian Li , Qingcheng Wang , Quansheng Cheng , Guichuan Xing , Songnan Qu . Rationally assembling different surface functionalized carbon dots for enhanced near-infrared tumor photothermal therapy. Acta Physico-Chimica Sinica, 2025, 41(9): 100109-0. doi: 10.1016/j.actphy.2025.100109
5. [5]
  Jianfu Zhang , Wei Bai , Juan Hou , Chenyang Zou . Reform and Practice of “Project-Patent- Scholarly Paper” Integrated Teaching Mode: Taking “Polymer Processing” Course as an Example. University Chemistry, 2025, 40(4): 138-146. doi: 10.12461/PKU.DXHX202408138
6. [6]
  Zhixin Zhou , Ran Chen , Yuanjian Zhang , Songqin Liu , Yanfei Shen . 分析化学课程本硕一体化的全英文教学改革. University Chemistry, 2025, 40(6): 64-70. doi: 10.12461/PKU.DXHX202407093
7. [7]
  Lijun Huo , Mingcun Wang , Tianyi Zhao , Mingjie Liu . Exploration of Undergraduate and Graduate Integrated Teaching in Polymer Chemistry with Aerospace Characteristics. University Chemistry, 2024, 39(6): 103-111. doi: 10.3866/PKU.DXHX202312059
8. [8]
  Qiying Xia , Guokui Liu , Yunzhi Li , Yaoyao Wei , Xia Leng , Guangli Zhou , Aixiang Wang , Congcong Mi , Dengxue Ma . Construction and Practice of “Teaching-Learning-Assessment Integration” Model Based on Outcome Orientation: Taking “Structural Chemistry” as an Example. University Chemistry, 2024, 39(10): 361-368. doi: 10.3866/PKU.DXHX202311007
9. [9]
  Lin LI , Jiaxue LI , Meixia YANG , Jiayu DING , Jiaqi JING , Ruiping ZHANG . Preparation of mitoxantrone self-assembled carrier-free nanodrugs regulated by sodium acetate for apoptosis induction of human breast carcinoma cells. Chinese Journal of Inorganic Chemistry, 2025, 41(12): 2536-2548. doi: 10.11862/CJIC.20250138
10. [10]
  Wenjing ZHANG , Xiaoqing WANG , Zhipeng LIU . Recent developments of inorganic metal complex-based photothermal materials and their applications in photothermal therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2356-2372. doi: 10.11862/CJIC.20240254
11. [11]
  Chen Hu , Yu Wu , Lianqing Chen , Tao Huang , Chunya Li , Lin Li , Bingguang Zhang , Peng Mei . 基于“三位一体四融合”策略的化学实验室安全课程创新与探索. University Chemistry, 2025, 40(8): 25-32. doi: 10.12461/PKU.DXHX202410088
12. [12]
  Weiwei Zhang , Yongxin Ren , Hong Zhang , Ke Lu . Current Situation and Quality Improvement Measures of Undergraduate Education in Modern Analytical Testing Technology under the “Learning, Teaching, and Practicing” Trinity Concept. University Chemistry, 2025, 40(10): 78-85. doi: 10.12461/PKU.DXHX202412006
13. [13]
  Xuanzhu Huo , Yixi Liu , Qiyu Wu , Zhiqiang Dong , Chanzi Ruan , Yanping Ren . Integrated Experiment of “Electrolytic Preparation of Cu₂O and Gasometric Determination of Avogadro’s Constant: Implementation, Results, and Discussion: A Micro-Experiment Recommended for Freshmen in Higher Education at Various Levels Across the Nation. University Chemistry, 2024, 39(3): 302-307. doi: 10.3866/PKU.DXHX202308095
14. [14]
  Di WU , Ruimeng SHI , Zhaoyang WANG , Yuehua SHI , Fan YANG , Leyong ZENG . Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135
15. [15]
  Ruifeng CHEN , Chao XU , Jianting JIANG , Tianshe YANG . Gold nanorod/zinc oxide/mesoporous silica nanoplatform: A triple-modal platform for synergistic anticancer therapy. Chinese Journal of Inorganic Chemistry, 2025, 41(11): 2272-2282. doi: 10.11862/CJIC.20250117
16. [16]
  Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
17. [17]
  Shiyang He , Dandan Chu , Zhixin Pang , Yuhang Du , Jiayi Wang , Yuhong Chen , Yumeng Su , Jianhua Qin , Xiangrong Pan , Zhan Zhou , Jingguo Li , Lufang Ma , Chaoliang Tan . Pt Single-Atom-Functionalized 2D Al-TCPP MOF Nanosheets for Enhanced Photodynamic Antimicrobial Therapy. Acta Physico-Chimica Sinica, 2025, 41(5): 100046-0. doi: 10.1016/j.actphy.2025.100046
18. [18]
  Yaqian Zhou , Chunxin Zhao , Dan Zhang , Zhe Liu , Tianlong Zhang , Bin Cui , Yan Li . “Education-Access-Supervision” Trilateral Laboratory Safety Management Model: A Case of the National Demonstration Center for Experimental Chemistry Education at Northwest University. University Chemistry, 2025, 40(11): 346-353. doi: 10.12461/PKU.DXHX202506078
19. [19]
  Zhuoya WANG , Le HE , Zhiquan LIN , Yingxi WANG , Ling LI . Multifunctional nanozyme Prussian blue modified copper peroxide: Synthesis and photothermal enhanced catalytic therapy of self-provided hydrogen peroxide. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2445-2454. doi: 10.11862/CJIC.20240194
20. [20]
  Han ZHANG , Jianfeng SUN , Jinsheng LIANG . Hydrothermal synthesis and luminescent properties of broadband near-infrared Na₃CrF₆ phosphor. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 349-356. doi: 10.11862/CJIC.20240098

Get Citation

PDF

XML

Metrics

PDF Downloads(17)
Abstract views(1383)
HTML views(310)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142