Citation: LU Hui-Ting, LI Jin-Ze, WANG Ye-Yu, GE Ru-Jiao, DONG Hai-Feng. Research Progress of Microneedles in Interstitial Fluid Bioanalysis[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(6): 819-829,858. doi: 10.19756/j.issn.0253-3820.221013 shu

Research Progress of Microneedles in Interstitial Fluid Bioanalysis

LU Hui-Ting ¹ ,
LI Jin-Ze ^1,, ,
WANG Ye-Yu ¹ ,
GE Ru-Jiao ¹ ,
DONG Hai-Feng ^1,2,,

1.
Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry&Biological Engineering, University of Science&Technology Beijing, Beijing 100083, China;
2.
Marshall Laboratory of Biomedical Engineering, School of Biomedical Engineering, Shenzhen University, Shenzhen 518060, China

Corresponding author: LI Jin-Ze, DONG Hai-Feng,
Received Date: 8 January 2022
Revised Date: 23 March 2022

Fund Project: Supported by the National Natural Science Foundation of China(Nos. 21874008, 22004006, 22022407, 21890740, 21890742), the Special Foundation for State Major Research Program of China(No.2019YFC1606603) and the 2021 Stability Support Plan of Shenzhen University(No. 8940206/0200).

The collection and analysis of biological samples is the effective method for disease diagnosis and treatment. Blood sampling and analysis are standard methods in clinical diagnosis, but they are commonly invasive and usually cause tissue damage and patient discomfort. Interstitial fluid(ISF) is a promising alternative candidate of blood owing to the rich biological information; however,it is still great challenge to minimally and non-invasively sample sufficient targets in skin ISF. In recent years, microneedles(MNs) have received considerable attention in ISF research due to their high efficiency, safety, convenience and painless characteristics. As the micron-level needle array, MNs have achieved remarkable results in medical cosmetology, molecular delivery, diagnostic monitoring and disease treatment, but little attention has been paid to the application of MNs for bioanalysis in ISF. This review summarizes the materials of microneedle, and details the application of MNs in ISF sampling,biomarker capture and analysis, and wearable sensing, while exploring the development prospects of MNs as an emerging research field and summarizing the challenges to be considered and existing in the transformation of technological achievements.
- Microneedles,
- Bioanalysis,
- Fluid extraction,
- Minimally invasive,
- Review
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