Citation: YE Jia-Yue, ZENG Wei-Biao, WEI Yi-Ping. Application of Direct Injection Mass Spectrometry in Clinical Diagnosis of Thoracic Tumors[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(4): 484-491. doi: 10.19756/j.issn.0253-3820.211216 shu

Application of Direct Injection Mass Spectrometry in Clinical Diagnosis of Thoracic Tumors

Department of Thoracic Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China

Corresponding author: WEI Yi-Ping, weiyip2000@hotmail.com
Received Date: 17 March 2021
Revised Date: 4 October 2022

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 81860379, 82160410).

Mass spectrometry (MS) analysis has become one of the core technologies for clinical disease research. Traditional mass spectrometry techniques such as liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) often require multi-step pre-processing of different clinical samples, which can not meet the practical requirements of large samples and high throughput analysis in clinical settings, while these needs are driving the development of new technologies for mass spectrometry from laboratory to clinical applications. The lack of ideal preoperative diagnostic protocols for chest malignancies such as lung cancer and esophageal cancer, the long waiting time for intraoperative pathology to assess the nature of the cut edge, and the lack of ideal models to assess the risk of recurrence in the postoperative period are among the main reasons for ″under-treatment″ and ″over-treatment″ in clinical practice. This is one of the main reasons for ″under-treatment″ and ″over-treatment″ in clinical practice. Direct injection mass spectrometry has high specificity and sensitivity, which effectively improves the accuracy of sample nature determination and decreases the analysis time of samples in clinical analysis, providing important guidance for clinical diagnosis and chest tumor research. This review introduced the progress of the application of direct injection mass spectrometry in the perioperative diagnosis of thoracic tumors, and briefly described the prospects of the application of direct injection mass spectrometry combined with histological methods to explore thoracic tumor biomarkers for the prevention of postoperative recurrence.
- Mass spectrometry,
- Direct injection mass spectrometry,
- Thoracic tumor,
- Clinical diagnosis,
- Review
1. [1]
  LU B W, BAUM L, SO K F, CHIU K, XIE L K. Neural Regen. Res., 2019, 14(9):1494-1498.
2. [2]
  LIMA N M, FERNANDES B L M, ALVES G F, DE SOUZA J C Q, SIQUEIRA M M, PATRÍCIA DO NASCIMENTO M, MOREIRA O B O, SUSSULINI A, DE OLIVEIRA M A L. Anal. Chim. Acta, 2022, 1195:339385.
3. [3]
  HU S C, BRYANT M S, SEPEHR E, KANG H K, TRBOJEVICH R, LAGAUD G, MEHTA D, DING W, MITTELSTAEDT R A, PEARCE M G, BISHOP M E, DAVIS K J, LEWIS S M, CHEMERYNSKI S, YEE S B, CORAGGIO M, ROSENFELDT H, YEAGER R P, HOWARD P C, TANG Y. Toxicol. Sci., 2021, 182(1):10-28.
4. [4]
  YU K W, LI B L, YUAN Y S, LIAO J M, LI W K, DONG H, KE P F, JIN X, CHEN L, ZHAO J J, WANG H, CAO S W, CHEN W Y, HUANG X Z, ZHAO B B, KANG C M. Heliyon, 2022, 8(8):e10214.
5. [5]
  YAGIHASHI G, TARUI T, MIYAGI H, OHNISHI H, WATANABE T, YAMAGUCHI Y. Acute Med. Surg., 2020, 7(1):e487.
6. [6]
  DUAN M, QIN L, ZHONG D, ZHANG P. Biomed. Chromatogr., 2019, 33(10):e4618.
7. [7]
  FAN S Y, ZANG C Z, SHIH P H, KO Y C, HSU Y H, LIN M C, TSENG S H, WANG D Y. Forensic Sci. Int., 2021, 325:110884.
8. [8]
  KIRBY A E, LAFRENIÈRE N M, SEALE B, HENDRICKS P I, COOKS R G, WHEELER A R. Anal. Chem., 2014, 86(12):6121-6129.
9. [9]
  WANG H, LI L, XING R, ZHANG Y, WU T, CHEN B, LI Z, FEI Z, LIU Z, DING H. Food Chem., 2019, 272:411-417.
10. [10]
  CODY R B, LARAMÉE J A, DURST H D. Anal. Chem., 2005, 77(8):2297-2302.
11. [11]
  TAKÁTS Z, COTTE-RODRIGUEZ I, TALATY N, CHEN H, COOKS R G. Chem. Commun., 2005, 41(15):1950-1952.
12. [12]
  CHEN H, VENTER A, COOKS R G. Chem. Commun., 2006, 48(19):2042-2044.
13. [13]
  ZHANG H, ZHU L, LUO L, WANG N, CHINGIN K, GUO X, CHEN H. J. Agric. Food Chem., 2013, 61(45):10691-10698.
14. [14]
  NA N, ZHANG C, ZHAO M, ZHANG S, YANG C, FANG X, ZHANG X. J. Mass Spectrom., 2007, 42(8):1079-1085.
15. [15]
  HARPER J D, CHARIPAR N A, MULLIGAN C C, ZHANG X, COOKS R G, OUYANG Z. Anal. Chem., 2008, 80(23):9097-9104.
16. [16]
  LI H, VERTES A. Analyst, 2017, 142(16):2921-2927.
17. [17]
  BOKHART M T, MANNI J, GARRARD K P, EKELÖF M, NAZARI M, MUDDIMAN D C. J. Am. Soc. Mass Spectrom., 2017, 28(10):2099-2107.
18. [18]
  ASHRAFIZADEH M, ZARRABI A, HUSHMANDI K, KALANTARI M, MOHAMMADINEJAD R, JAVAHERI T, SETHI G. Int. J. Mol. Sci., 2020, 21(11):4002.
19. [19]
  SUNG H, FERLAY J, SIEGEL R L, LAVERSANNE M, SOERJOMATARAM I, JEMAL A, BRAY F. CA Cancer J. Clin., 2021, 71(3):209-249.
20. [20]
  GAMEZ G, ZHU L, DISKO A, CHEN H, AZOV V, CHINGIN K, KRÄMER G, ZENOBI R. Chem. Commun., 2011, 47(17):4884-4886.
21. [21]
  FANG Z, HE J, FANG W, RUAN L, FANG F. Heart Lung Circ., 2016, 25(4):392-397.
22. [22]
  FUJIWARA Y, YOSHIKAWA R, KAMIKONYA N, NAKAYAMA T, KITANI K, TSUJIE M, YUKAWA M, INOUE M, YAMAMURA T. Oncol. Rep., 2012, 28(2):446-452.
23. [23]
  GUI Y, LU Y, LI S, ZHANG M, DUAN X, LIU C C, JIA J, LIU G. Sci. Rep., 2020, 10(1):15550.
24. [24]
  WANG S, LI F, LIU Y Z, ZHAO H, CHEN H. Anal. Bioanal. Chem., 2019, 411(18):4049-4054.
25. [25]
  LAPOINTE J, MUSSELMAN B, O'NEILL T, SHEPARD J R E. J. Am. Soc. Mass Spectrom., 2015, 26(1):159-165.
26. [26]
27. [27]
  ALFARO C M, JARMUSCH A K, PIRRO V, KERIAN K S, MASTERSON T A, CHENG L, COOKS R G. Anal. Bioanal. Chem., 2016, 408(20):5407-5414.
28. [28]
29. [29]
30. [30]
  WARNER E, JOTKOWITZ A, MAIMON N. Eur. J. Intern. Med., 2010, 21(1):6-11.
31. [31]
  PINSKY P F, BELLINGER C R, MILLER JR D P. J. Med. Screen., 2018, 25(2):110-112.
32. [32]
  YEEN T N S, PATHMANATHAN R, SHIRAN M S, ZAID F A A, CHEAH Y K. J. Biomed. Sci., 2013, 20(1):22.
33. [33]
  MAIONE P, ROSSI A, SACCO P C, BARESCHINO M A, SCHETTINO C, GRIDELLI C. Expert Opin. Pharmacother., 2010, 11(18):2997-3007.
34. [34]
  KANG C, WANG D, ZHANG X, WANG L, WANG F, CHEN J. Comput. Math. Methods Med., 2021, 2021:9987067.
35. [35]
  LI F, WEI F, HUANG W L, LIN C C, LI L, SHEN M M, YAN Q, LIAO W, CHIA D, TU M, TANG J H, FENG Z, KIM Y, SU W C, WONG D T W. Cancers (Basel), 2020, 12(8):2041.
36. [36]
  KAPELERIS J, MÜLLER BARK J, RANJIT S, IRWIN D, HARTEL G, WARKIANI M E, LEO P, O'LEARY C, LADWA R, O'BYRNE K, HUGHES B G M, PUNYADEERA C. Heliyon, 2022, 8(7):e09971.
37. [37]
  LU H, ZHANG H, WEI Y, CHEN H. Analyst, 2020, 145(2):313-320.
38. [38]
  FIGUEIREDO E C, SANVIDO G B, ZEZZI ARRUDA M A, EBERLIN M N. Analyst, 2010, 135(4):726-730.
39. [39]
  GU H, CHEN H, PAN Z, JACKSON A U, TALATY N, XI B, KISSINGER C, DUDA C, MANN D, RAFTERY D, COOKS R G. Anal. Chem., 2007, 79(1):89-97.
40. [40]
  PLEKHOVA V, VAN MEULEBROEK L, DE GRAEVE M, PERDONES-MONTERO A, DE SPIEGELEER M, DE PAEPE E, VAN DE WALLE E, TAKATS Z, CAMERON S J S, VANHAECKE L. Nat. Protoc., 2021, 16(9):4327-4354.
41. [41]
  GORDON S M, SZIDON J P, KROTOSZYNSKI B K, GIBBONS R D, O'NEILL H J. Clin. Chem., 1985, 31(8):1278-1282.
42. [42]
  PHILLIPS M, GLEESON K, HUGHES J M B, GREENBERG J, CATANEO R N, BAKER L, MCVAY W P. Lancet, 1999, 353(9168):1930-1933.
43. [43]
  BLANCO F G, VIDAL-DE-MIGUEL G. Crit. Rev. Anal. Chem., 2021:DOI:10.1080/10408347.2021.1981226.
44. [44]
  ZHU J, BEAN H D, WARGO M J, LECLAIR L W, HILL J E. J. Breath Res., 2013, 7(1):016003.
45. [45]
  MARTINEZ-LOZANO SINUES P, LANDONI E, MICELI R, DIBARI V F, DUGO M, AGRESTI R, TAGLIABUE E, CRISTONI S, ORLANDI R. J. Breath Res., 2015, 9(3):031001.
46. [46]
  ZUO W, BAI W, GAN X, XU F, WEN G, ZHANG W. J. Biomed. Nanotechnol., 2019, 15(4):633-646.
47. [47]
  ROSENTHAL K, RUSZKIEWICZ D M, ALLEN H, LINDLEY M R, TURNER M A, HUNSICKER E. J. Breath Res., 2019, 13(4):046013.
48. [48]
  WEI Y, CHEN L, ZHOU W, CHINGIN K, OUYANG Y, ZHU T, WEN H, DING J, XU J, CHEN H. Sci. Rep., 2015, 5(1):10077.
49. [49]
  ZHANG J, XU J, LU H, DING J, YU D, LI P, XIONG J, LIU X, CHEN H, WEI Y. Oncotarget, 2016, 7(39):63158-63165.
50. [50]
  ZHENG Q, ZHANG J, WANG X, ZHANG W, XIAO Y, HU S, XU J. Onco. Targets Ther., 2021, 14:469-479.
51. [51]
  KERIAN K S, JARMUSCH A K, PIRRO V, KOCH M O, MASTERSON T A, CHENG L, COOKS R G. Analyst, 2015, 140(4):1090-1098.
52. [52]
  PIRRO V, ALFARO C M, JARMUSCH A K, HATTAB E M, COHEN-GADOL A A, COOKS R G. Proc. Natl. Acad. Sci. U. S. A., 2017, 114(26):6700-6705.
53. [53]
  JARMUSCH A K, ALFARO C M, PIRRO V, HATTAB E M, COHEN-GADOL A A, COOKS R G. PLoS One, 2016, 11(9):e0163180.
54. [54]
  BENSUSSAN A V, LIN J, GUO C, KATZ R, KRISHNAMURTHY S, CRESSMAN E, EBERLIN L S. Clin. Chem., 2020, 66(11):1424-1433.
55. [55]
  HE M J, PU W, WANG X, ZHANG W, TANG D, DAI Y. Front. Oncol., 2022, 12:891018.
56. [56]
  BALOG J, SASI-SZABÓ L, KINROSS J, LEWIS M R, MUIRHEAD L J, VESELKOV K, MIRNEZAMI R, DEZSŐ B, DAMJANOVICH L, DARZI A, NICHOLSON J K, TAKÁTS Z. Sci. Transl. Med., 2013, 5(194):194ra193.
57. [57]
  SCHÄFER K C, DÉNES J, ALBRECHT K, SZANISZLÓ T, BALOG J, SKOUMAL R, KATONA M, TÓTH M, BALOGH L, TAKÁTS Z. Angew. Chem. Int. Ed., 2009, 48(44):8240-8242.
58. [58]
  ZHANG J, RECTOR J, LIN J Q, YOUNG J H, SANS M, KATTA N, GIESE N, YU W, NAGI C, SULIBURK J, LIU J, BENSUSSAN A, DEHOOG R J, GARZA K Y, LUDOLPH B, SORACE A G, SYED A, ZAHEDIVASH A, MILNER T E, EBERLIN L S. Sci. Transl. Med., 2017, 9(406):eaan3968.
59. [59]
  BALOG J, SZANISZLO T, SCHAEFER K C, DENES J, LOPATA A, GODORHAZY L, SZALAY D, BALOGH L, SASI-SZABO L, TOTH M, TAKATS Z. Anal. Chem., 2010, 82(17):7343-7350.
60. [60]
  ST JOHN E R, BALOG J, MCKENZIE J S, ROSSI M, COVINGTON A, MUIRHEAD L, BODAI Z, ROSINI F, SPELLER A V M, SHOUSHA S, RAMAKRISHNAN R, DARZI A, TAKATS Z, LEFF D R. Breast Cancer Res., 2017, 19(1):59.
61. [61]
  MCDONNELL L A, CORTHALS G L, WILLEMS S M, VAN REMOORTERE A, VAN ZEIJL R J M, DEELDER A M. J. Proteomics, 2010, 73(10):1921-1944.
62. [62]
  BATESON H, SALEEM S, LOADMAN P M, SUTTON C W. J. Pharmacol. Toxicol. Methods, 2011, 64(3):197-206.
63. [63]
  SCHÖNE C, HÖFLER H, WALCH A. Clin. Biochem., 2013, 46(6):539-545.
64. [64]
  CHEN H, PAN Z, TALATY N, RAFTERY D, COOKS R G. Rapid Commun. Mass Spectrom., 2006, 20(10):1577-1584.
65. [65]
  GOUW A M, EBERLIN L S, MARGULIS K, SULLIVAN D K, TOAL G G, TONG L, ZARE R N, FELSHER D W. Proc. Natl. Acad. Sci. U. S. A., 2017, 114(17):4300-4305.
66. [66]
  LU H, ZHANG H, CHINGIN K, WEI Y, XU J, KE M, HUANG K, FENG S, CHEN H. Anal. Chem., 2019, 91(16):10532-10540.
67. [67]
  SUN C, LI T, SONG X, HUANG L, ZANG Q, XU J, BI N, JIAO G, HAO Y, CHEN Y, ZHANG R, LUO Z, LI X, WANG L, WANG Z, SONG Y, HE J, ABLIZ Z. Proc. Natl. Acad. Sci. U. S. A., 2019, 116(1):52-57.
68. [68]
  MA X, FERNáNDEZ F M. Mass Spectrom. Rev., 2022:e21804.
1. [1]
  Zunxiang Zeng , Yuling Hu , Yufei Hu , Hua Xiao . Analysis of Plant Essential Oils by Supercritical CO₂Extraction with Gas Chromatography-Mass Spectrometry: An Instrumental Analysis Comprehensive Experiment Teaching Reform. University Chemistry, 2024, 39(3): 274-282. doi: 10.3866/PKU.DXHX202309069
2. [2]
  Jingyi Chen , Fu Liu , Tiejun Zhu , Kui Cheng . Practice of Integrating Ideological and Political Education into Raman Spectroscopy Analysis Experiment Course. University Chemistry, 2024, 39(2): 140-146. doi: 10.3866/PKU.DXHX202310111
3. [3]
  Xin Hua , Songqin Liu . Research on Teaching Practice of Spectral Analytical Chemistry Based on Thematic Discussion. University Chemistry, 2025, 40(7): 106-111. doi: 10.12461/PKU.DXHX202408043
4. [4]
  Yanhui Zhong , Ran Wang , Zian Lin . Analysis of Halogenated Quinone Compounds in Environmental Water by Dispersive Solid-Phase Extraction with Liquid Chromatography-Triple Quadrupole Mass Spectrometry. University Chemistry, 2024, 39(11): 296-303. doi: 10.12461/PKU.DXHX202402017
5. [5]
  Zhi Zhou , Yu-E Lian , Yuqing Li , Hui Gao , Wei Yi . New Insights into the Molecular Mechanism Behind Clinical Tragedies of “Cephalosporin with Alcohol”. University Chemistry, 2025, 40(3): 42-51. doi: 10.12461/PKU.DXHX202403104
6. [6]
  Zian Lin , Yingxue Jin . Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) for Disease Marker Screening and Identification: A Comprehensive Experiment Teaching Reform in Instrumental Analysis. University Chemistry, 2024, 39(11): 327-334. doi: 10.12461/PKU.DXHX202403066
7. [7]
  Aiai WANG , Lu ZHAO , Yunfeng BAI , Feng FENG . Research progress of bimetallic organic framework in tumor diagnosis and treatment. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1825-1839. doi: 10.11862/CJIC.20240225
8. [8]
  Tingting XU , Wenjing ZHANG , Yongbo SONG . Research advances of atomic precision coinage metal nanoclusters in tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2275-2285. doi: 10.11862/CJIC.20240229
9. [9]
  Jian Li , Yu Zhang , Rongrong Yan , Kaiyuan Sun , Xiaoqing Liu , Zishang Liang , Yinan Jiao , Hui Bu , Xin Chen , Jinjin Zhao , Jianlin Shi . 高效靶向示踪钙钛矿纳米系统光电增效抗肿瘤. Acta Physico-Chimica Sinica, 2025, 41(5): 100042-. doi: 10.1016/j.actphy.2024.100042
10. [10]
  Jiahao Zeng , Hui Chao . 诱导程序性细胞死亡的金属抗肿瘤药物研究. University Chemistry, 2025, 40(6): 145-159. doi: 10.12461/PKU.DXHX202406019
11. [11]
  Fa Wang , Yu Chen , Hui Chao . Ruthenium(II) Complexes as Photoactivated Chemo-Prodrugs for Hypoxic Tumor Therapy. University Chemistry, 2025, 40(7): 200-212. doi: 10.12461/PKU.DXHX202410024
12. [12]
  Ping Song , Nan Zhang , Jie Wang , Rui Yan , Zhiqiang Wang , Yingxue Jin . Experimental Teaching Design on Synthesis and Antitumor Activity Study of Cu-Pyropheophorbide-a Methyl Ester. University Chemistry, 2024, 39(6): 278-286. doi: 10.3866/PKU.DXHX202310087
13. [13]
  Jiahui CHEN , Tingting ZHENG , Xiuyun ZHANG , Wei LÜ . Research progress of near-infrared absorption inorganic nanomaterials in photothermal and photodynamic therapy of tumors. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2396-2414. doi: 10.11862/CJIC.20240106
14. [14]
  Jing WU , Puzhen HUI , Huilin ZHENG , Pingchuan YUAN , Chunfei WANG , Hui WANG , Xiaoxia GU . Synthesis, crystal structures, and antitumor activities of transition metal complexes incorporating a naphthol-aldehyde Schiff base ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2422-2428. doi: 10.11862/CJIC.20240278
15. [15]
  Yiming Liang , Ziyan Pan , Kin Shing Chan . One Drink, Two Tears in the Central Nervous System: The Perils of Disulfiram-Like Reactions. University Chemistry, 2025, 40(4): 322-325. doi: 10.12461/PKU.DXHX202406016
16. [16]
  Jiandong Liu , Zhijia Zhang , Mikhail Kamenskii , Filipp Volkov , Svetlana Eliseeva , Jianmin Ma . Research Progress on Cathode Electrolyte Interphase in High-Voltage Lithium Batteries. Acta Physico-Chimica Sinica, 2025, 41(2): 100011-. doi: 10.3866/PKU.WHXB202308048
17. [17]
  Xianyong Lu , Tao Hu . Developing an Innovative Inorganic Chemistry Teaching Model Based on Aerospace Specialty Characteristics. University Chemistry, 2025, 40(7): 127-131. doi: 10.12461/PKU.DXHX202409037
18. [18]
  Xinran Zhang , Siqi Liu , Yichi Chen , Qingli Zou , Qinghong Xu , Yaqin Huang . From Protein to Energy Storage Materials: Edible Gelatin Jelly Electrolyte. University Chemistry, 2025, 40(7): 255-266. doi: 10.12461/PKU.DXHX202408104
19. [19]
  Zhuoyan Lv , Yangming Ding , Leilei Kang , Lin Li , Xiao Yan Liu , Aiqin Wang , Tao Zhang . Light-Enhanced Direct Epoxidation of Propylene by Molecular Oxygen over CuO_x/TiO₂ Catalyst. Acta Physico-Chimica Sinica, 2025, 41(4): 100038-. doi: 10.3866/PKU.WHXB202408015
20. [20]
  Zhaoxuan ZHU , Lixin WANG , Xiaoning TANG , Long LI , Yan SHI , Jiaojing SHAO . Application of poly(vinyl alcohol) conductive hydrogel electrolytes in zinc ion batteries. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 893-902. doi: 10.11862/CJIC.20240368

Get Citation

PDF

XML

Metrics

PDF Downloads(7)
Abstract views(1116)
HTML views(60)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142