Citation: PENG Hao, YANG Fang, DU Hui, JIANG Bo, YAO Chen-Yang, YAO Jun-Lie, ZHENG Fang, WU Ai-Guo. Advances of Er³⁺ Doped Upconversion Nanoparticles for Biological Imaging[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(7): 1106-1120. doi: 10.19756/j.issn.0253-3820.211090 shu

Advances of Er³⁺ Doped Upconversion Nanoparticles for Biological Imaging

Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences (CAS), CAS Key Laboratory of Magnetic Materials and Devices & Zhejiang Engineering Research Center for Biomedical Materials, Ningbo 315201, China

Corresponding author: WU Ai-Guo, aiguo@nimte.ac.cn
Received Date: 31 January 2021
Revised Date: 20 May 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 32025021, 31971292, 51873225) and the Ministry of Science and Technology of China (No. 2018YFC0910601, SQ2019YFA040008-03).

Upconversion nanoparticles can emit high-energy photons in visible region under the excitation of near-infrared light. Compared with traditional fluorescent materials, upconversion nanoparticles show better tissue penetration depth and biocompatibility, and also reduce the fluorescence interference of biological cells and tissues. Therefore, upconversion nanoparticles have broad application prospects in the field of highly sensitivie biological imaging. Erbium (Er) has a strong absorption in the near infrared Ⅱ region (1500 nm), and can emit red or green light. With the excellent optical properties, Erbium is usually doped in the upconversion nanoparticles as the emission center. However, due to the problems of surface quenching and energy countercurrent, the upconversion nanoparticles doped with Er³⁺ have limited luminescence efficiency and low biological imaging performance. In this review, the development of Er³⁺ doped upconversion nanoparticles in optical properties optimization and biological imaging applications are summarized, and the latest progress and development prospects of Er³⁺ doped upconversion nanoparticle materials in the domain of temporal pathway imaging are discussed and prospected.
- Upconversion luminescence,
- Erbium doping,
- Biological imaging,
- Multimodal imaging,
- Time domain spectroscopy,
- Review
1. [1]
  BLOEMBERGEN N. Phys. Rev. Lett., 1959, 2(3): 84-85.
2. [2]
  LOO J F C, CHIEN Y H, YIN F, KONG S K, HO H P, YONG K T. Coord. Chem. Rev., 2019, 400: 213042.
3. [3]
  AUZEL F. Chem. Rev., 2004, 104(1): 139-173.
4. [4]
  DONG H, SUN L D, YAN C H. Chem. Soc. Rev., 2015, 44(6): 1608-1634.
5. [5]
  JIA F F, LI G L, YANG B, YU B, SHEN Y Q, CONG H L. Nanotechnol. Rev., 2019, 8(1): 1-17.
6. [6]
  MADER S H, KELE P, SALEH M S, WOLFBEIS S O. Chem. Biol., 2010, 14(5): 582-596.
7. [7]
  FAN Y, WANG P Y, LU Y Q, WANG R, ZHOU L, ZHENG X L, LI X M, PIPER J A, ZHANG F. Nat. Nanotechnol., 2018, 13: 941-946.
8. [8]
  LU Y Q, LU J, ZHAO J B, CUSIDO J, RAYMO F M, YUAN J L, YANG S, LEIF R C, HUO Y J, PIPER J A, PAUL R J, GOLDYS E M, JIN D Y. Nat. Commun., 2014, 5: 3741.
9. [9]
  XIANG G T, LIU X T, XIA Q, LIU X C, XU S, JIANG S, ZHAO X J, LI L, WU D, MA L, WANG X J, ZHANG J H. Talanta, 2021, 224: 121832.
10. [10]
  CHEN S, WEITEMIER A Z, ZENG X, HE L M, WANG X Y, TAO Y Q, HUANG A J Y, HASHIMOTODANI Y, KANO M, IWASAKI H, PARAJULI L K, OKABE S, TEH D B L, ALL A H, TSUTSUI-KIMURA I, TANAKA K F, LIU X G, MCHUGH T J. Science, 2018, 359(6376): 679-684.
11. [11]
  THAO C T B, HUY B T, SHARIPOV M, KIM J I, DAO V D, MOON J Y, LEE Y I. Mater. Sci. Eng. C, 2017, 75: 990-997.
12. [12]
  ZHAO J X, CHEN X, CHEN B, LUO X, SUN T Y, ZHANG W W, WANG C J, LIN J, SU D, QIAO X S, WANG F. Adv. Funct. Mater., 2019, 29(44): 1903295.
13. [13]
  DONG H, SUN L D, YAN C H. Nanoscale, 2013, 5(13): 5703-5714.
14. [14]
  ZHOU B, SHI B Y, JIN D Y, LIU X G. Nat. Nanotechnol., 2015, 10(11): 924-936.
15. [15]
  CHEN G Y, OHULCHANSKYY T Y, KACHYNSKI A, AGREN H, PRASAD P N. ACS Nano, 2011, 5(6): 4981-4986.
16. [16]
  SHALAV A, RICHARDS B S, TRUPKE T, KRAMER K W, GUDEL H U. Appl. Phys. Lett., 2005, 86: 013505.
17. [17]
  BINNEMANS K. Chem. Rev., 2009, 109(9): 4283-4374.
18. [18]
  WANG F, LIU X G. Acc. Chem. Rev., 2014, 47(4): 1378-1385.
19. [19]
  TU L P, LIU X M, WU F, ZHANG H. Chem. Soc. Rev., 2015, 44: 1331-1345.
20. [20]
  ZUO J, LIU Q Q, XUE B, LI C X, CHANG Y L, ZHANG Y L, LIU X M, TU L P, ZHANG H, KONG X G. Nanoscale, 2017, 9(23): 7941-7946.
21. [21]
  DU P, LUO L H, YU S J. Part. Part. Syst. Charact., 2018, 35(3): 1700416.
22. [22]
  XIANG G T, LIU X T, XIA Q, LIU X C, XU S, JIANG S, ZHOU X J, LI L, WU D, MA L, WANG X J, ZHANG J H. Talanta, 2021, 224: 121832.
23. [23]
  LUO R, CHEN L, LI Q Y, ZHOU J, MEI L Q, NING Z L, ZHAO Y, LIU M J, LAI X, BI J, YIN W Y, GAO D J. Inorg. Chem., 2020, 59(24): 17906-17915.
24. [24]
  YADAV R S, DHOBLE S J, RAI S B. New J. Chem., 2018, 42(9): 7272-7282.
25. [25]
  CHUNG J W, KWAK M, YANG H K. Luminescence, 2021, 36(3): 812-818.
26. [26]
  YADAV R S, VERMA R K, RAI B S. J. Phys. D: Appl. Phys., 2013, 46(27): 275101.
27. [27]
  TADGE P, YADAV R S, VISHWAKARMA P K, RAI S B, CHEN T M, SAPRA S, RAY S. J. Alloy Compd., 2020, 821: 153230.
28. [28]
  KADAM A R, YADAV R S, MISHRA G C, DHOBLE S J. Ceram. Int., 2020, 46(3): 3264-3274.
29. [29]
  WU Y F, LAI F Q, LIU B, LI Z B, LIANG T X, QIANG Y C, HUANG J H, YE X Y, YOU W X. J. Rare Earths, 2020, 38(2): 130-138.
30. [30]
  DUBEY A, SONI A K, KUMARI A, DEY R, RAI V K. J. Alloy Compd., 2017, 693: 194-200.
31. [31]
  CHENG Q, SUI J H, CAI W. Nanoscale, 2012, 4(3): 779-784.
32. [32]
  WANG X W, ZHANG X, WANG Y B, LI H Y, XIE J, WEI T, HUANG Q W, XIE X J, HUANG L, HUANG W. Dalton Trans., 2017, 46(280): 8968-8974.
33. [33]
  SUN Y Z, BI H F, WANG T, SUN L L, LI Z X, SONG H N, SUN F L, ZHOU H F, ZHOU G J, HU J F. Mater. Sci. Eng., B, 2020, 261: 114674.
34. [34]
  ZHOU A H, SONG F, HAN Y D, SONG F F, JU D D, WANG X Q. CrystEngComm, 2018, 20(14): 2029.
35. [35]
  LIN H, WANG Z G, HONG Y. J. Nanomater., 2020, 2020: 8509380.
36. [36]
  ZHENG K Z, LOH K Y, WANG Y, CHEN Q S, FAN J Y, JUNG T Y, NAM S H, SUH Y D, LIU X G. Nano Today, 2019, 29: 100797.
37. [37]
  YI G S, CHOW G M. Chem. Mater., 2007, 19(3): 341-343.
38. [38]
  XIANG G T, ZHANG J H, HAO Z D, ZHANG X, PAN G H, LUO Y S, LV W, ZHAO H F. Inorg. Chem., 2015, 54(8): 3921-3928.
39. [39]
  HOMANN C, KRUEWITT L, FRENZEL F, GRAUEL B, WURTH C, RESCH-GENGER U, HAASE M. Angew. Chem., Int. Ed., 2018, 57(28): 8765-8769.
40. [40]
  WURTH C, FISCHER S, GRAUEL B, ALIVISATOS A P, RESCH-GENGER U. J. Am. Chem. Soc., 2018, 140: 4922-4928.
41. [41]
  RABIE H, ZHANG Y X, PASQUALE N, LAGOS M J, BATSON P E, LEE K B. Adv. Mater., 2019, 31(14): 1806991.
42. [42]
  MENG Z, ZHANG S F, WU S L. J. Lumin., 2020, 227: 117566.
43. [43]
  ZUO J, SUN D P, TU L P, WU Y N, CAO Y H, XUE B, ZHANG Y L, CHANG Y L, LIU X M, KONG X G, BUMA W J, MEIJER E J, ZHANG J. Angew. Chem., Int. Ed., 2018, 57(12): 3054-3058.
44. [44]
  XIE X J, LI Z J, ZHANG Y W, GUO S H, PENDHARKAR A I, LU M, HUANG L, HUANG W, HAN G. Samll, 2017, 13(6): 1602843.
45. [45]
  HE J J, ZHENG W, LIGMAJER F L, CHAN C F, BAO Z Y, WONG K L, CHEN X Y, HAO J H, DAI J Y, YU S F, LEI D Y. Light: Sci. Appl., 2017, 6: e16217.
46. [46]
  LI J F, GUO H L, LI Z Y. Photon. Res., 2013, 1(1): 28-41.
47. [47]
  FANG C H, JIA H L, CHANG S, RUAN Q F, WANG P, CHEN T, WANG J F. Energy Environ. Sci., 2014, 7(10): 3431-3438.
48. [48]
  GAO Wei, WANG Bo-Yang, HAN Qin-Yan, HAN Shan-Shan, CHENG Xiao-Tong, ZHANG Chen-Xue, SUN Ze-Yu, LIU Lin, YAN Xue-Wen, WANG Yong-Kai, DONG Jun. Acta Physica sini
49. [49]
  KANG F W, HE J J, SUN T Y, BAO Z Y, WANG F, LEI D Y. Adv. Funct. Mater., 2017, 27(36): 1701842.
50. [50]
  CALOS L D, FERREIRA R A S, BERMUDEZ V D Z, RIBEIRO S J. Adv. Mater., 2009, 21(5): 509-534.
51. [51]
  GU B, ZHANG Q C. Adv. Sci., 2018, 5(3): 1700609.
52. [52]
  TAN G R, WANG M H, HSU C Y, CHEN N G, ZHANG Y. Adv. Optical Mater., 2016, 4(7): 984-997.
53. [53]
  ZHU X H, ZHANG J, LIU J L, ZHANG Y. Adv. Sci., 2019, 6(22): 1901358.
54. [54]
55. [55]
  WOLFBEIS O S. Chem. Soc. Rev., 2015, 44(14): 4743-4768.
56. [56]
  ZHANG Z M, SHIKHA S, LIU J L, ZHANG J, MEI Q S, ZHANG Y. Anal. Chem., 2019, 91: 548-568.
57. [57]
  LI S H, WEI X D, LI S S, ZHU C M, WU C H. Int. J. Nanomed., 2020, 15: 9431-9445.
58. [58]
  WEN S H, ZHOU J J, ZHENG K Z, BEDNARKIEWICZ A, LIU X G, JIN D Y. Nat. Commun., 2018, 9: 2415.
59. [59]
  LIANG G F, WANG H J, SHI H, WANG H T, ZHU M X, JING A H, LI J H, LI G D. J. Nanobiotechnol., 2020, 18(1): 154.
60. [60]
  CHATTERJEE D K, RUFAIHAH A J, ZHANG Y. Biomaterials, 2008, 29(7): 937-943.
61. [61]
  HUANG M, WANG L J, ZHANG X J, ZHOU J, LIU L H, PAN Y F, YU B, YU Z S. Nano, 2017, 12(5): 1750057.
62. [62]
  REDDY K L, PRABHAKAR N, ARPPE R, ROSENHOLM J M, KRISHNAN V. J. Mater. Sci., 2017, 52(10): 5738-5750.
63. [63]
  YANG G, CAO Y, YAN B, LV Q, YU J B, ZHAO F S, CHEN Z H, YANG H R, CHEN M X, JIN Z S. Oncotarget, 2018, 9(24): 16758-16774.
64. [64]
  VU D T, VU-LE T T, NGUYEN V N, LE Q M, WANG C R C, CHAU L K, YANG T S, CHAN M W Y, LEE C I, TING C C, LIN J Y, KAN H C, HSU C C. Int. J. Smart Nano Mater., 2021, 12(1): 49-71.
65. [65]
  ZOU X M, XU M, YUAN W, WANG Q H, SHI Y B, FENG W, LI F Y. Chem. Conmmun., 2016, 52(91): 13389-13392.
66. [66]
  CHEN G Y, SHAO W, VALIEV R R, OHULCHANSKYY T Y, HE G S, AGREN H, PRASAD P N. Adv. Optical Mater., 2016, 4(11): 1760-1766.
67. [67]
  WU X, ZHANG Y W, TAKLE K, BILSEL O, LI Z J, LEE H, ZHANG Z J, LI D S, FAN W, DUAN C Y, CHAN E M, LOIS C, XIANG Y, HAN G. ACS Nano, 2016, 10(1): 1060-1066.
68. [68]
  CHHETRI B P, KARMAKAR A, GHOSH A. Part. Part. Syst. Charact., 2019, 36(8): 1900153.
69. [69]
  LI X, ZHANG X N, LI X D, CHANG J. Cancer Biol. Med., 2016, 13(3): 339-348.
70. [70]
  ZHOU J, SUN Y, DU X X, XIONG L Q, HU H, LI F Y. Biomaterials, 2010, 31(12): 3287-3295.
71. [71]
  LIU Y, KANG N, LV J, ZHOU Z J, ZHAO Q L, MA L C, CHEN Z, REN L, NIE L M. Adv. Mater., 2016, 28(30): 6411-6419.
72. [72]
  LUO Y, ZHANG W, LIAO Z F, YANG S N, YANG S T, LI X H, ZUO F, LUO J B. Nanomaterials, 2018, 8(7): 466.
73. [73]
  KANG N, LIU Y, ZHOU Y M, WANG D, CHEN C, YE S F, NIE L M, REN L. Adv. Healthcare Mater., 2016, 5(11): 1356-1363.
74. [74]
  HE F, YANG G X, YANG P P, YU Y X, LV R C, LI C X, DAI Y L, GAI S L, LIN J. Adv. Funct. Mater., 2015, 25(25): 3966-3976.
75. [75]
  LIU F Y, HE X X, LEI Z, LIU L, ZHANG J P, YOU H P, ZHANG H M, WANG Z X. Adv. Healthcare Mater., 2015, 4(4): 559-568.ca, 2020, 69(18): 184213.
76. [76]
  SUN M Z, XU L G, MA W, WU X L, KUANG H, WANG L B, XU C L. Adv. Mater., 2016, 28(5): 898-904.
77. [77]
  LU Y Q, ZHAO J B, ZHANG R, LIU Y J, LIU D M, GOLDYS E M, YANG X S, XI P, SUNNA A, LU J, SHI Y, LEIF R C, HUO Y J, SHEN J, PIPER J A, ROBINSON J P, JIN D Y. Nat. Photonics, 2014, 8(1): 33-37.
78. [78]
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沈阳化工大学材料科学与工程学院沈阳 110142

Advances of Er3+ Doped Upconversion Nanoparticles for Biological Imaging

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通讯作者: 陈斌, bchen63@163.com

Advances of Er³⁺ Doped Upconversion Nanoparticles for Biological Imaging