Citation: CAI Qi-Yong, LEI Yang, LI Zhao-Hui. Application Advances in Single Molecule Array Technology for Diagnosis of Disease[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(7): 1154-1165. doi: 10.19756/j.issn.0253-3820.211087 shu

Application Advances in Single Molecule Array Technology for Diagnosis of Disease

College of Chemistry, Zhengzhou University, Zhengzhou 450001, China

Corresponding author: LI Zhao-Hui, zhaohui.li@zzu.edu.cn
Received Date: 30 January 2021
Revised Date: 25 April 2021

Fund Project: Supported by the Zhengzhou Major Project for Collaborative Innovation (No.18XTZX12002).

Single molecule array technology (Simoa) is a digital enzyme-linked immunosorbent assay (ELISA) that performs single-molecule enzymatic reactions in microwell with a volume of femtoliters and enables fluorescence imaging. Simoa has many advantages such as rapidity, high sensitivity and wide detection range, which has shown great application potential in the fields of bioanalysis, disease diagnosis and prognosis evaluation. On the basis of summarizing the principles and key technologies of Simoa, in this article, the application progress of Simoa in the fields of neurodegenerative diseases, tumors, infectious diseases, etc., were mainly reviewed, and application prospects of Simoa were anticipated.
- Single molecule array,
- Fluorescence imaging,
- Digital enzyme-linked immunosorbent assay,
- Diagnosis,
- Review
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沈阳化工大学材料科学与工程学院沈阳 110142