Citation: ZHAN Jia-Yin, LIU Ran, ZHANG Jing-Jing. Progress of Stimuli-responsive Nanomaterials in Tumor Analysis[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(7): 1133-1141. doi: 10.19756/j.issn.0253-3820.211086 shu

Progress of Stimuli-responsive Nanomaterials in Tumor Analysis

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China

Corresponding author: ZHANG Jing-Jing, jing15209791@nju.edu.cn
Received Date: 29 January 2021
Revised Date: 12 April 2021

Fund Project: Supported by the National Natural Science Foundation of China (No. 22004063), the Natural Science Foundation of Jiangsu Province (No. 20200303) and the Innovation Fund of Nanjing University (No. 020514913414).

Under the trigger of endogenous stimuli (such as pH, overexpressed enzymes, redox, etc.) or exogenous stimuli (such as light, temperature, magnetic fields, etc.), stimuli-responsive nanomaterials can change their structures and properties in tumor tissues, so as to achieve precise drug delivery and imaging. Due to the differences in structure, composition and function, these stimuli-responsive nanomaterials have exhibited diverse applications, such as photothermal therapy, chemotherapy or imaging by triggered drug delivery. To explore the potential applications of stimuli-responsive nanomaterials, this review focuses on exogenous light-responsive and/or endogenous enzyme-responsive nanomaterials and summarizes the research progress in the areas of tumor-related therapy and bioimaging in the past few years.
- Light-responsive,
- Enzyme-responsive,
- Nanomaterials,
- Oncotherapy,
- Bioimaging,
- Review
1. [1]
  HANAHAN D, WEINBERG R A. Cell, 2011, 144(5): 646-674.
2. [2]
  CHINEN A B, GUAN C M, FERRER J R, BARNABY S N, MERKEL T J, MIRKIN C A. Chem. Rev., 2015, 115(19): 10530-10574.
3. [3]
  SHI J J, KANTOFF P W, WOOSTER R, FAROKHZAD O C. Nat. Rev. Cancer, 2017, 17(1): 20-37.
4. [4]
  DONG P, RAKESH K P, MANUKUMAR H M, MOHAMMED Y H E, KARTHIK C S, SUMATHI S, MALLU P, QIN H L. Bioorg. Chem., 2019, 85: 325-336.
5. [5]
  KASHKOOLI F M, SOLTANI M, SOURI M. J. Controlled Release, 2020, 327: 316-349.
6. [6]
  THAKKAR S, SHARMA D, KALIA K, TEKADE R K. Acta Biomater., 2020, 101: 43-68.
7. [7]
  PHAM S H, CHOI Y, CHOI J. Pharmaceutics, 2020, 12(7): 630.
8. [8]
  RACCA L, CAUDA V. Nano-Micro Lett., 2020, 13(1): 11.
9. [9]
  ZHANG M, GUO X L, WANG M F, LIU K H. J. Controlled Release, 2020, 323: 203-224.
10. [10]
  ALEJO T, USON L, ARRUEBO M. J. Controlled Release, 2019, 314: 162-176.
11. [11]
  RAZA A, RASHEED T, NABEEL F, HAYAT U, BILAL M, IQBAL H M N. Molecules, 2019, 24(6): 1117.
12. [12]
  LUO Z M, JIN K, PANG Q, SHEN S, YAN Z Q, JIANG T, ZHU X Y, YU L, PANG Z Q, JIANG X G. ACS Appl. Mater. Interfaces, 2017, 9(37): 31612-31625.
13. [13]
  ESPINOSA A, DI CORATO R, KOLOSNJAJ-TABI J, FLAUD P, PELLEGRINO T, WILHELM C. ACS Nano, 2016, 10(2): 2436-2446.
14. [14]
  SANEJA A, KUMAR R, ARORA D, KUMAR S, PANDA A K, JAGLAN S. Drug Discov. Today, 2018, 23(5): 1115-1125.
15. [15]
  KATO Y, OZAWA S, MIYAMOTO C, MAEHATA Y, SUZUKI A, MAEDA T, BABA Y. Cancer Cell Int., 2013, 13(1): 1-8.
16. [16]
  LI Y, GAO G H, LEE D S. J. Polym. Sci., Part A: Polym. Chem., 2013, 51(19): 4175-4182.
17. [17]
  THOMAS R G, SURENDRAN S P, JEONG Y Y. Front. Mol. Biosci., 2020, 7: 1516-1526.
18. [18]
  LI M, ZHAO G, SU W K, SHUAI Q. Front. Chem., 2020, 8: 647.
19. [19]
  MI P. Theranostics, 2020, 10(10): 4557-4588.
20. [20]
  MOHAPATRA A, UTHAMAN S, PARK I K. Front. Mol. Biosci., 2021, 7: 597634.
21. [21]
  DYKMAN L, KHLEBTSOV N. Chem. Soc. Rev., 2012, 41(6): 2256-2282.
22. [22]
  CASTILLO R R, LOZANO D, GONZALEZ B, MANZANO M, IZQUIERDO-BARBA I, VALLET-REGI M. Expert Opin. Drug Deliv., 2019, 16(4): 415-439.
23. [23]
  DONG H, DU S R, ZHENG X Y, LYU G M, SUN L D, LI L D, ZHANG P Z, ZHANG C, YAN C H. Chem. Rev., 2015, 115(19): 10725-10815.
24. [24]
  LI L, XING H, ZHANG J, LU Y. Acc. Chem. Res., 2019, 52(9): 2415-2426.
25. [25]
  MAL N K, FUJIWARA M, TANAKA Y. Nature, 2003, 421(6921): 350-353.
26. [26]
  WANG X R, HU J M, LIU G H, TIAN J, WANG H J, GONG M, LIU S Y. J. Am. Chem. Soc., 2015, 137(48): 15262-15275.
27. [27]
  LIU Y, HE M, NIU M M, ZHAO Y Q, ZHU Y Z, LI Z H, FENG N P. Int. J. Nanomed., 2015, 10: 3081-3095.
28. [28]
  MARTINEZ-CARMONA M, LOZANO D, BAEZA A, COLILLA M, VALLET-REGI M. Nanoscale, 2017, 9(41): 15967-15973.
29. [29]
  YANG G B, LIU J J, WU Y F, FENG L Z, LIU Z. Coord. Chem. Rev., 2016, 320: 100-117.
30. [30]
  YUAN A, WU J, TANG X, ZHAO L, XU F, HU Y. J. Pharm. Sci., 2013, 102(1): 6-28.
31. [31]
  LI X N, SCHUMANN C, ALBARQI H A, LEE C J, ALANI A W G, BRACHA S, MILOVANCEV M, TARATULA O, TARATULA O. Theranostics, 2018, 8(3): 767-784.
32. [32]
  ZHAO J, CHU H, ZHAO Y, LU Y, LI L. J. Am. Chem. Soc., 2019, 141(17): 7056-7062.
33. [33]
  CHU H, ZHAO J, MI Y, ZHAO Y, LI L. Angew. Chem., Int. Ed., 2019, 58(42): 14877-14881.
34. [34]
  LI C Y, ZHENG B, KANG Y F, TANG H W, PANG D W. ACS Sens., 2020, 5(1): 199-207.
35. [35]
  HUANG L, LI Z J, ZHAO Y, ZHANG Y W, WU S, ZHAO J Z, HAN G. J. Am. Chem. Soc., 2016, 138(44): 14586-14591.
36. [36]
  VANKAYALA R, KUO C L, NUTHALAPATI K, CHIANG C S, HWANG K C. Adv. Funct. Mater., 2015, 25(37): 5934-5945.
37. [37]
  GOODMAN A M, NEUMANN O, NORREGAARD K, HENDERSON L, CHOI M R, CLARE S E, HALAS N J. Proc. Natl. Acad. Sci. U. S. A., 2017, 114(47): 12419-12424.
38. [38]
  DAI Y L, BI H T, DENG X R, LI C X, HE F, MA P A, YANG P P, LIN J. J. Mat. Chem. B, 2017, 5(11): 2086-2095.
39. [39]
  LIU D, YANG F, XIONG F, GU N. Theranostics, 2016, 6(9): 1306-1323.
40. [40]
  JO Y, CHOI N, KIM K, KOO H J, CHOI J, KIM H N. Theranostics, 2018, 8(19): 5259-5275.
41. [41]
  EGEBLAD M, WERB Z. Nat. Rev. Cancer, 2002, 2(3): 161-174.
42. [42]
  LI X, KIM J, YOON J, CHEN X Y. Adv. Mater., 2017, 29(23): 1606857
43. [43]
  CALLMANN C E, BARBACK C V, THOMPSON M P, HALL D J, MATTREY R F, GIANNESCHI N C. Adv. Mater., 2015, 27(31): 4611-4615.
44. [44]
  HU X, YANG P, HE J, LIANG R, NIU D, WANG H, LI Y. J. Mater. Chem. B, 2017, 5(30): 5931-5936.
45. [45]
  LIU Y, DING X, LI J, LUO Z, HU Y, LIU J, DAI L, ZHOU J, HOU C, CAI K. Nanotechnology, 2015, 26(14): 145102
46. [46]
  HAN H J, VALDEPEREZ D, JIN Q, YANG B, LI Z H, WU Y L, PELAZ B, PARAK W J, JI J. ACS Nano, 2017, 11(2): 1281-1291.
47. [47]
  LI H, WANG P, DENG Y X, ZENG M Y, TANG Y, ZHU W H, CHENG Y S. Biomaterials, 2017, 139: 30-38.
48. [48]
  WHITE B D, DUAN C, TOWNLEY H E. Biomolecules, 2019, 9(5): 202.
49. [49]
  HUANG Y, SONG C, LI H, ZHANG R, JIANG R, LIU X, ZHANG G, FAN Q, WANG L, HUANG W. ACS Appl. Mater. Interfaces, 2015, 7(38): 21529-21537.
50. [50]
  SHI H, GAO T, SHI L, CHEN T S, XIANG Y, LI Y Y, LI G X. Sci. Rep., 2018, 8: 16341.
51. [51]
  YUE X, QIAO Y, GU D, WU Z, ZHAO W, LI X, YIN Y, ZHAO W, KONG D, XI R, MENG M. Sens. Actuators, B, 2020, 312: 127943.
52. [52]
  ZHENG F F, WANG C, MENG T T, ZHANG Y Q, ZHANG P H, SHEN Q, ZHANG Y C, ZHANG J F, LI J X, MIN Q H, CHEN J N, ZHU J J. ACS Nano, 2019, 13(11): 12577-12590.
53. [53]
  CHEN C Y, KIM T H, WU W C, HUANG C M, WEI H, MOUNT C W, TIAN Y, JANG S H, PUN S H, JEN A K Y. Biomaterials, 2013, 34(18): 4501-4509.
54. [54]
  DUTTA S, SAMANTA P, DHARA D. Int. J. Biol. Macromol., 2016, 87: 92-100.
55. [55]
  AN X, ZHU A, LUO H, KE H, CHEN H, ZHAO Y. ACS Nano, 2016, 10(6): 5947-5958.
56. [56]
  YANG K, LIU Y, WANG Y, REN Q, GUO H, MATSON J B, CHEN X, NIE Z. Biomaterials, 2019, 223: 119460.
57. [57]
  GAO S, ZHANG L W, WANG G H, YANG K, CHEN M L, TIAN R, MA Q J, ZHU L. Biomaterials, 2016, 79: 36-45.
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