Citation: LI Shen-wan, HUANG Tong-dai, ZHAI Bei-bei, JIANG Yun-jing, CAO Yu-yu, WANG Zu-xi, WEI Jie, SUN Hong-mei. Fabrication and Analysis of Wound Hemostasis and Antibacterial Properties of Silver Nanoparticles-Mesoporous Chabazite-Non-woven Composites[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(4): 554-563. doi: 10.19756/j.issn.0253-3820.210892 shu

Fabrication and Analysis of Wound Hemostasis and Antibacterial Properties of Silver Nanoparticles-Mesoporous Chabazite-Non-woven Composites

Key Laboratory of Fermentation Engineering（Ministry of Education), National ‘111’ Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Industrial Microbiology in Hubei, School of Bioengineering and Food, Hubei University of Technology, Wuhan 430068, China

Corresponding author: SUN Hong-mei, hmsunqi@163.com
Received Date: 14 December 2021
Revised Date: 17 January 2022

Fund Project: Supported by the National Natural Science Foundation of China(No. 21501054)

Mesoporous chabazite-non-woven was prepared by in situ growth method using non-woven as the substrate, and then silver nanoparticles-mesoporous chabazite-non-woven(AgNPs-mCHA-NW) composite material was obtained after AgNPs were anchored. The structure and morphology of the as-prepared materials were characterized by X-ray diffraction(XRD), field-emission scanning electron microscope(FE-SEM), X-ray photoelectron spectroscopy(XPS), automatic physical adsorption instrument(BET), and thermogravimetric analysis(TGA). The anticoagulant rabbit blood was used to evaluate the hemostatic result of the as-prepared materials in vitro. The antibacterial properties of the materials against Escherichia coli(E. coli) and Staphylococcus aureus(S. aureus) were studied by inhibition zone method. Finally, the mouse tail vein incision model was established to investigate the hemostatic effect of the material in vivo. The experiment results showed that the clotting time in vitro and hemostatic time in vivo of AgNPs-mCHA-NW were lower than that of commercial hemostatic gauze, which indicated that AgNPs-mCHA-NW had good hemostatic effect. The results of the inhibition zone experiment proved that the antibacterial performance of AgNPs-mCHA-NW was significantly better than the commercial silver nanoparticles wound bandage(AgNPs-WB). AgNPs-mCHA-NW combined mesoporous chabazite with AgNPs, which not only achieved rapid and effective hemostasis of wounds, but also showed great antibacterial property, thus providing a new platform for emergency treatment and rapid recovery of massive bleeding wounds.
- Non-woven,
- Chabazite,
- Silver nanoparticles,
- Hemostatic effect,
- Antibacterial properties
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