Citation: CAI Dong-Ming, OUYANG Jie, DING Jin-Jian, LIN Min, ZHANG Wei-Wei, LI Min-Jie, GUO Liang-Hong. Research Progress on Identification and Toxic Effects of Antibiotics Disinfection By-products[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(3): 327-340. doi: 10.19756/j.issn.0253-3820.210811 shu

Research Progress on Identification and Toxic Effects of Antibiotics Disinfection By-products

CAI Dong-Ming ^1,2 ,
OUYANG Jie ^2,3 ,
DING Jin-Jian ^2,3 ,
LIN Min ⁴ ,
ZHANG Wei-Wei ⁴ ,
LI Min-Jie ^3,, ,
GUO Liang-Hong ^2,3,,

¹College of Life Sciences, China Jiliang University, Hangzhou 310018, China;
²Institute of Environmental and Health Sciences, China Jiliang University, Hangzhou 310018, China;
³College of Quality and Safety Engineering, China Jiliang University, Hangzhou 310018, China;
⁴Hangzhou Jasu Environmental Monitoring Co., Ltd., Hangzhou 310018, China

Corresponding author: LI Min-Jie, GUO Liang-Hong,
Received Date: 25 October 2021
Revised Date: 31 December 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos.U20A20133, 21878302).

Due to extensive use and persistent discharge, the environmental levels of antibiotics have been increasing over time. The concentrations of some antibiotics in surface water have reached 300 ng/L, while those in drinking water sources have exceeded 200 ng/L. During disinfection process of drinking water, the antibiotics react with the disinfectants to produce a variety of by-products, some of which are carcinogenic or acutely toxic. These antibiotic disinfection by-products (DBPs) pose direct threat to human health, and thus become the frontier research topic in environmental health science. Based on the studies mostly published in the recent years, this review summarized the analytical methods of DBPs from five major categories of antibiotics (Chloramphenicols, sulfanilamides, fluoroquinolones, tetracyclines, macrolides) including sample pretreatment, chromatography separation and spectroscopic and mass spectrometry detection. Identified DBPs under specific disinfection conditions were then described according to the category of the antibiotics. Furthermore, common toxicity test methods including luminescent bacteria inhibition were introduced, and the test results of some antibiotic DBPs were described. A variety of antibiotic DBPs were identified in previous studies, and some of them were shown to be more toxic than their precursors and thus deserved further investigation.
- Antibiotics,
- Disinfection by-products,
- Analytical methods,
- Toxicity tests,
- Review
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