Citation: LIU Shuang, JIANG Wen-Shuo, LAN Xin-Yu, LENG Jun-Qiang, JIA Wen-Xuan, LIU Zhen-Bo. Research Progress of Hydrogen Peroxide Fluorescent Probes[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(3): 341-355. doi: 10.19756/j.issn.0253-3820.210768 shu

Research Progress of Hydrogen Peroxide Fluorescent Probes

College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China

Corresponding author: LIU Zhen-Bo, zhenboliu@foxmail.com
Received Date: 25 September 2021
Revised Date: 11 November 2021

Fund Project: Supported by the National Natural Science Foundation of China (No.22075241) and the Natural Science Foundation of Shandong Province, China (No.ZR2019QB017).

Hydrogen peroxide (H₂O₂) is one of the most important reactive oxygen species (ROS) which is related to many physiological and pathological processes in biological systems. Therefore, to understand the important role of hydrogen peroxide in living systems, many fluorescent probes for hydrogen peroxide detection in the biological field have been developed in recent years. Compared with traditional detection methods, fluorescent probes have many advantages such as high sensitivity, non-invasive detection and real-time imaging. In this paper, the research progress of hydrogen peroxide probes in the past five years based on different fluorophores was reviewed, and the challenges and prospect in this field were described.
- Hydrogen peroxide,
- Fluorescent probe,
- Cell imaging,
- Review
1. [1]
  GEISZT M, LETO T L. J. Biol. Chem., 2004, 279(50):51715-51718.
2. [2]
  VEAL E A, DAY A M, MORGAN B A. Mol. Cell, 2007, 26(1):1-14.
3. [3]
  KANVAH S, JOSEPH J, SCHUSTER G B, BARNETT R N, CLEVELAND C L, LANDMAN U. Acc. Chem. Res., 2010, 43(2):280-287.
4. [4]
  AMES B N, SHIGENAGA M K, HAGEN T M. Proc. Natl. Acad. Sci. U.S.A., 1993, 90(17):7915-7922.
5. [5]
  RADEKE H H, MEIER B, TOPLEY N, FLÖGE J, HABERMEHL G G, RESCH K. Kidney Int., 1990, 37(2):767-775.
6. [6]
  BEHL C, DAVIS J B, LESLEY R, SCHUBERT D. Cell, 1994, 77(6):817-827.
7. [7]
  ABE J I, BERK B C. Trends Cardiovasc. Med., 1998, 8(2):59-64.
8. [8]
  GILL R, BAHSHI L, FREEMAN R, WILLNER I. Angew. Chem., Int. Ed., 2008, 47(9):1676-1679.
9. [9]
  ZHANG Y, DAI M, YUAN Z. Anal. Methods, 2018, 10(38):4625-4638.
10. [10]
  MILLER E W, ALBERS A E, PRALLE A, ISACOFF E Y, CHANG C J. J. Am. Chem. Soc., 2005, 127(47):16652-16659.
11. [11]
  KUMAR V M, SANGEETHA D, SANJEEVA Y, JOSEPH J J. J. Indian Chem. Soc., 2015, 92(4):472-474.
12. [12]
  BEHERA T K, SAHU S C, SATPATI B, BAG B, SANJAY K, JENA B K. Electrochim. Acta, 2016, 206:238-245.
13. [13]
  COCHEMÉ H M, LOGAN A, PRIME T A, ABAKUMOVA I, QUIN C, MCQUAKER S J, PATEL J V, FEARNLEY I M, JAMES A M, PORTEOUS C M, SMITH R A J, HARTLEY R C, PARTRIDGE L, MURPHY M P. Nat. Protoc., 2012, 7(5):946-958.
14. [14]
  VAN DE BITTNER G C, DUBIKOVSKAYA E A, BERTOZZI C R, CHANG C J. Proc. Natl. Acad. Sci. U.S.A., 2010, 107(50):21316-21321.
15. [15]
  LIANG L, LAN F, LI L, SU M, GE S, YU J, LIU H, YAN M. Biosens. Bioelectron., 2016, 82:204-211.
16. [16]
  RHEE S G, CHANG T S, JEONG W, KANG D. Mol. Cell, 2010, 29(6):539-549.
17. [17]
  CHEN X, WANG F, HYUN J Y, WEI T, QIANG J, REN X, SHIN I, YOON J. Chem. Soc. Rev., 2016,45(10):2976-3016.
18. [18]
  REN M, DENG B, ZHOU K, KONG X, WANG J Y, LIN W. Anal. Chem., 2017, 89(1):552-555.
19. [19]
  XIAO H, LI P, HU X, SHI X, ZHANG W, TANG B. Chem. Sci., 2016, 7(9):6153-6159.
20. [20]
  LIU K, SHANG H, KONG X, REN M, WANG J Y, LIU Y, LIN W. Biomaterials, 2016, 100:162-171.
21. [21]
  NARAYANASWAMY N, NARRA S, NAIR R R, SAINI D K, KONDAIAH P, GOVINDARAJU T. Chem. Sci., 2016, 7(4):2832-2841.
22. [22]
  SONG Z, KWOK R T K, DING D, NIE H, LAM J W Y, LIU B, TANG B Z. Chem. Commun., 2016, 52(65):10076-10079.
23. [23]
  XIE X, YANG X E, WU T, LI Y, LI M, TAN Q, WANG X, TANG B. Anal. Chem., 2016, 88(16):8019-8025.
24. [24]
  DONG B, SONG X, KONG X, WANG C, TANG Y, LIU Y, LIN W. Adv. Mater., 2016, 28(39):8755-8759.
25. [25]
  ABO M, URANO Y, HANAOKA K, TERAI T, KOMATSU T, NAGANO T. J. Am. Chem. Soc., 2011,133(27):10629-10637.
26. [26]
  REJA S I, GUPTA M, GUPTA N, BHALLA V, OHRI P, KAUR G, KUMAR M. Chem. Commun., 2017,53(26):3701-3704.
27. [27]
  YU F, LI P, SONG P, WANG B, ZHAO J, HAN K. Chem. Commun., 2012, 48(41):4980-4982.
28. [28]
  LI N, HUANG J, WANG Q, GU Y, WANG P. Sens. Actuators, B, 2018, 254:411-416.
29. [29]
  JIANG W L, WANG W X, LIU J, LI Y, LI C Y. Sens. Actuators, B, 2020, 313:128054.
30. [30]
  SHEN Y M, ZHANG X Y, ZHANG Y Y, WU Y Y, ZHANG C X, CHEN Y D, JIN J L, LI H T. Sens. Actuators, B, 2018, 255:42-48.
31. [31]
  ANG C Y, TAN S Y, WU S J, QU Q Y, WONGM F E, LUO Z, LI P Z, SELVAN S T, ZHAO Y L. J. Mater. Chem. C, 2016, 4(14):2761-2774.
32. [32]
  HAN J L, LIU X J, XIONG H Q, WANG J P, WANG B H, SONG X Z, WANG W. Anal. Chem., 2020,92(7):5134-5142.
33. [33]
  VELUSAMY N, THIRUMALAIVASAN N, BOBBA K N, PODDER A, WUS P, BHUNIYA S. J. Photochem. Photobiol., B, 2019, 191:99-106.
34. [34]
  WANG P, WANG K, CHEN D, MAO Y, GU Y. RSC Adv., 2015, 5(104):85957-85963.
35. [35]
  ZHOU Z L, LI Y Q, SU W, GU B, XU H, WU C Y, YIN P, LI H T, ZHANG Y Y. Sens. Actuators, B, 2019, 280:120-128.
36. [36]
  WANG W X, JIANG W L, LIU Y, LI Y, ZHANG J, LI C Y. Sens. Actuators, B, 2020, 320:128296.
37. [37]
  WANG P, WANG K, GU Y. Sens. Actuators, B, 2016, 228:174-179.
38. [38]
  XIONG J C, XIA L L, LI L S, CUI M Y, GU Y Q, WANG P. Sens. Actuators, B, 2019, 288:127-132.
39. [39]
  KIM D, KIM G, NAM S J, YIN J, YOON J. Sci. Rep., 2015, 5:8488.
40. [40]
  REN M, DENG B, WANG J Y, KONG X, LIU Z R, ZHOU K, HE L, LIN W. Biosens. Bioelectron., 2016, 79:237-243.
41. [41]
  GAO C C, TIAN Y, ZHANG R B, JING J, ZHANG X L. Anal. Chem., 2017, 89(23):12945-12950.
42. [42]
  LEE J, YOON S A, CHUN J, KANG C, LEE M H. Anal. Chim. Acta, 2019, 1080:153-161.
43. [43]
  ZHAO P, WANG K, ZHU X, ZHOU Y, WU J. Dyes Pigm., 2018, 155:143-149.
44. [44]
  LI B S, CHEN J B, XIONG Y, YANG X, ZHAO C D, SUN J. Sens. Actuators, B, 2018, 268:475-484.
45. [45]
  PURDEY M S, MCLENNAN H J, SUTTON-MCDOWALL M L, DRUMM D W, ZHANG X, CAPON P K, HENG S, THOMPSON J G, ABELL A D. Sens. Actuators, B, 2018, 262:750-757.
46. [46]
  LI X, ZHAO Y, ZHENG J, ZHANG T. J. Lumin., 2021, 229:117642.
47. [47]
  LEI Y J, XUE C, ZHANG S C, SHA Y W. Luminescence, 2016, 31(3):660-664.
48. [48]
  HUANG X, LI Z, LIU Z, ZENG C, HU L. Dyes Pigm., 2019, 165:518-523.
49. [49]
  ZHANG J, SHI L, LI Z, LI D, TIAN X, ZHANG C. Analyst, 2019, 144(11):3643-3648.
50. [50]
  XU F, LI H D, YAO Q C, FAN J L, WANG J Y, PENG X J. J. Mater. Chem. B, 2016, 4(46):7363-7367.
51. [51]
  NIE J, LIU Y, NIU J, NI Z H, LIN W Y. J. Photochem. Photobiol. A, 2017, 348:1-7.
52. [52]
  CHEN Q X, CHENG K, WANG W H, YANG L, XIE Y S, FENG L, ZHANG J, ZHANG H T, SUN H Y. J. Pharm. Anal., 2020, 10(5):490-497.
53. [53]
  LIU J, LIANG J, WU C, ZHAO Y. Anal. Chem., 2019, 91(10):6902-6909.
54. [54]
  GU T, MO S, MU Y, HUANG X, HU L. Sens. Actuators, B, 2020, 309:127731.
55. [55]
  XU J, ZHANG Y, YU H, GAO X D, SHAO S J. Anal. Chem., 2016, 88(2):1455-1461.
56. [56]
  CHEN Y, SHI X, LU Z, WANG X, WANG Z. Anal. Chem., 2017, 89(10):5278-5284.
57. [57]
  HOU J L, QIAN M, ZHAO H H, LI Y C, LIAO Y F, HAN G F, XU Z L, WANG F, SONG Y G, LIU Y P. Anal. Chim. Acta, 2018, 1024:169-176.
58. [58]
  HUANG J X, LI T T, LIU R N, ZHANG R, WANG Q Q, LI N, GU Y Q, WANG P. Sens. Actuators, B, 2017, 248:257-264.
59. [59]
  HAN J L, CHU C Y, CAO G X, MAO W X, WANG S, ZHAO Z, GAO M Q, YE H, XU X W. Bioorg. Chem., 2018, 81:362-366.
60. [60]
  HE L, LIU X, ZHANG Y, YANG L, FANG Q, GENG Y, CHEN W, SONG X. Sens. Actuators, B, 2018, 276:247-253.
61. [61]
  LIU X J, TIAN H H, YANG L, SU Y A, GUO M, SONG X Z. Sens. Actuators, B, 2018, 255:1160-1165.
62. [62]
  DE SILVA A P, GUNARATNE H Q N, GUNNLAUGSSON T, HUXLEY A J M, MCCOY C P, RADEMACHER J T, RICE T E. Chem. Rev., 1997, 97(5):1515-1566.
63. [63]
  GUO Z, ZHU W, TIAN H. Chem. Commun., 2012, 48(49):6073-6084.
64. [64]
  ZHANG W, LIU W, LI P, HUANG F, WANG H, TANG B. Anal. Chem., 2015, 87(19):9825-9828.
65. [65]
  ABO M, MINAKAMI R, MIYANO K, KAMIYA M, NAGANO T, URANO Y, SUMIMOTO H. Anal. Chem., 2014, 86(12):5983-5990.
66. [66]
  LI H, YAO Q, FAN J, DU J, WANG J, PENG X. Biosens. Bioelectron., 2017, 94:536-543.
67. [67]
  LEE H Y, JIANG X, LEE D. Org. Lett., 2009, 11(10):2065-2068.
68. [68]
  MEYER Y, RICHARD J A, DELEST B, NOACK P, RENARD P Y, ROMIEU A. Org.Biomol. Chem., 2010,8(8):1777-1780.
69. [69]
  SRIVASTAVA P, ALI R, RAZI S S, SHAHID M, MISRA A. Sens. Actuators, B, 2013, 181:584-595.
70. [70]
  ELGEMEIE G H, MOHAMED R A. J. Mol. Struct., 2018, 1173:707-742.
71. [71]
  LI Y, XIE X, YANG X E, LI M, JIAO X, SUN Y, WANG X, TANG B. Chem. Sci., 2017, 8(5):4006-4011.
72. [72]
  XIE X, LIU G, SU X, LI Y, LIU Y, JIAO X, WANG X, TANG B. Anal. Chem., 2019, 91(10):6872-6879.
73. [73]
  LIM C S, CHO M K, PARK M Y, KIM H M. Chem. Open, 2018, 7(1):53-56.
74. [74]
  ZHOU L, PENG Y, WANG Q, LIN Q. J. Photochem. Photobiol., B, 2017, 167:264-268.
75. [75]
  TREIBS A, KREUZER F H. Justus Liebigs Ann. Chem., 1968, 718(1):208-223.
76. [76]
  LU H, MACK J, YANG Y, SHEN Z. Chem. Soc. Rev., 2014, 43(13):4778-4823.
77. [77]
  ERANDE Y, CHEMATE S, MORE A, SEKAR N. RSC Adv., 2015, 5(109):89482-89487.
78. [78]
  LIEBERWIRTH U, ARDEN-JACOB J, DREXHAGE K H, HERTEN D P, MVLLER R, NEUMANN M, SCHULZ A, SIEBERT S, SAGNER G, KLINGEL S, SAUER M, WOLFRUM J. Anal. Chem., 1998, 70(22):4771-4779.
79. [79]
  FU M, XIAO Y, QIAN X, ZHAO D, XU Y. Chem. Commun., 2008, (15):1780-1782.
80. [80]
  HILDERBRAND S A, WEISSLEDER R. Curr. Opin. Chem. Biol., 2010, 14(1):71-79.
81. [81]
  KIYOSE K, KOJIMA H, NAGANO T. Chem.- Asian J., 2008, 3(3):506-515.
1. [1]
  Yanxi LIU , Mengjia XU , Haonan CHEN , Quan LIU , Yuming ZHANG . A fluorescent-colorimetric probe for peroxynitrite-anion-imaging in living cells. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1112-1122. doi: 10.11862/CJIC.20240423
2. [2]
  Pengli GUAN , Renhu BAI , Xiuling SUN , Bin LIU . Trianiline-derived aggregation-induced emission luminogen probe for lipase detection and cell imaging. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1817-1826. doi: 10.11862/CJIC.20250058
3. [3]
  Yuting DU , Jing YUAN , Peiyao DENG . Synthesis and application of a fluorescent probe for the detection of reduced glutathione. Chinese Journal of Inorganic Chemistry, 2025, 41(7): 1331-1337. doi: 10.11862/CJIC.20240461
4. [4]
  Qiang HU , Zhiqi CHEN , Zhong CHEN , Xu WANG , Weina WU . Pyridinium-chalcone-based ClO^- fluorescent probe: Preparation and biological imaging applications. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1789-1795. doi: 10.11862/CJIC.20250086
5. [5]
  Jinlong YAN , Weina WU , Yuan WANG . A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154
6. [6]
  Liu Lin , Zemin Sun , Huatian Chen , Lian Zhao , Mingyue Sun , Yitao Yang , Zhensheng Liao , Xinyu Wu , Xinxin Li , Cheng Tang . Recent Advances in Electrocatalytic Two-Electron Water Oxidation for Green H₂O₂ Production. Acta Physico-Chimica Sinica, 2024, 40(4): 2305019-0. doi: 10.3866/PKU.WHXB202305019
7. [7]
  Zhaoyu Wen , Na Han , Yanguang Li . Recent Progress towards the Production of H₂O₂ by Electrochemical Two-Electron Oxygen Reduction Reaction. Acta Physico-Chimica Sinica, 2024, 40(2): 2304001-0. doi: 10.3866/PKU.WHXB202304001
8. [8]
  Jiaxi Xu , Yuan Ma . Influence of Hyperconjugation on the Stability and Stable Conformation of Ethane, Hydrazine, and Hydrogen Peroxide. University Chemistry, 2024, 39(11): 374-377. doi: 10.3866/PKU.DXHX202402049
9. [9]
  Fan Fan , Hao Xiu , Yuting Wang , Yongpeng Cui , Yajun Wang . Construction of NH₂-MIL-125/Na-doped g-C₃N₄ composite S-scheme heterojunction and its performance in photocatalytic hydrogen peroxide production. Acta Physico-Chimica Sinica, 2026, 42(2): 100143-0. doi: 10.1016/j.actphy.2025.100143
10. [10]
  Jiakun BAI , Ting XU , Lu ZHANG , Jiang PENG , Yuqiang LI , Junhui JIA . A red-emitting fluorescent probe with a large Stokes shift for selective detection of hypochlorous acid. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1095-1104. doi: 10.11862/CJIC.20240002
11. [11]
  Yingpeng ZHANG , Xingxing LI , Yunshang YANG , Zhidong TENG . A pyrazole-based turn-off fluorescent probe for visual detection of hydrazine. Chinese Journal of Inorganic Chemistry, 2025, 41(7): 1301-1308. doi: 10.11862/CJIC.20250064
12. [12]
  Jun LUO , Baoshu LIU , Yunchang ZHANG , Bingkai WANG , Beibei GUO , Lan SHE , Tianheng CHEN . Europium(Ⅲ) metal-organic framework as a fluorescent probe for selectively and sensitively sensing Pb²⁺ in aqueous solution. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2438-2444. doi: 10.11862/CJIC.20240240
13. [13]
  Mahmoud Sayed , Han Li , Chuanbiao Bie . Challenges and prospects of photocatalytic H₂O₂ production. Acta Physico-Chimica Sinica, 2025, 41(9): 100117-0. doi: 10.1016/j.actphy.2025.100117
14. [14]
  Yanyan Zhao , Zhen Wu , Yong Zhang , Bicheng Zhu , Jianjun Zhang . Enhancing photocatalytic H₂O₂ production via dual optimization of charge separation and O₂ adsorption in Au-decorated S-vacancy-rich CdIn₂S₄. Acta Physico-Chimica Sinica, 2025, 41(11): 100142-0. doi: 10.1016/j.actphy.2025.100142
15. [15]
  Lei ZHANG , Cheng HE , Yang JIAO . An azo-based fluorescent probe for the detection of hypoxic tumor cells. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1162-1172. doi: 10.11862/CJIC.20250081
16. [16]
  Yu SU , Xinlian FAN , Yao YIN , Lin WANG . From synthesis to application: Development and prospects of InP quantum dots. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2105-2123. doi: 10.11862/CJIC.20240126
17. [17]
  Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
18. [18]
  Zhuoya WANG , Le HE , Zhiquan LIN , Yingxi WANG , Ling LI . Multifunctional nanozyme Prussian blue modified copper peroxide: Synthesis and photothermal enhanced catalytic therapy of self-provided hydrogen peroxide. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2445-2454. doi: 10.11862/CJIC.20240194
19. [19]
  Yu Dai , Xueting Sun , Haoyu Wu , Naizhu Li , Guoe Cheng , Xiaojin Zhang , Fan Xia . Determination of the Michaelis Constant for Gold Nanozyme-Catalyzed Decomposition of Hydrogen Peroxide. University Chemistry, 2025, 40(5): 351-356. doi: 10.12461/PKU.DXHX202407052
20. [20]
  Xiaofeng Zhu , Bingbing Xiao , Jiaxin Su , Shuai Wang , Qingran Zhang , Jun Wang . Transition Metal Oxides/Chalcogenides for Electrochemical Oxygen Reduction into Hydrogen Peroxides. Acta Physico-Chimica Sinica, 2024, 40(12): 2407005-0. doi: 10.3866/PKU.WHXB202407005

Get Citation

PDF

XML

Metrics

PDF Downloads(41)
Abstract views(1800)
HTML views(332)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142