Citation: WANG Wei, YU Bin, LYU Kai-Xuan, SUN Wen-Bo, WANG Da-Peng, LU Le-Hui. Preparation of Novel Nanozyme-motor and Its Antibacterial Properties[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(12): 1995-2004. doi: 10.19756/j.issn.0253-3820.210527 shu

Preparation of Novel Nanozyme-motor and Its Antibacterial Properties

WANG Wei ^1,2 ,
YU Bin ¹ ,
LYU Kai-Xuan ^2,3 ,
SUN Wen-Bo ¹ ,
WANG Da-Peng ^2,3 ,
LU Le-Hui ^1,2,,

1.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2.
School of Applied Chemical Engineering, University of Science and Technology of China, Hefei 230026, China;
3.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Corresponding author: LU Le-Hui, lehuilu@ciac.ac.cn
Received Date: 27 May 2021
Revised Date: 20 June 2021

Fund Project: Supported by the National Natural Science Foundation of China (No.21365007).

A nanozyme-motor (Cu/PDA) with peroxidase-like and catalase-like characteristics was constructed by in situ chelation between Cu²⁺ and polydopamine (PDA). Cu/PDA can efficiently catalyze the decomposition of hydrogen peroxide to produce oxygen for the movement of nano-motors and to generate highly toxic reactive oxygen species (ROS) for killing bacteria. Promoted by the photothermal effect of PDA, the diffusion range of nanozyme-motor was significantly expanded, which enhanced the damage range of ROS effectively. Antimicrobial experiments results showed that Cu/PDA could inhibit bacterial growth potently. Moreover, with the functional surface modification, Cu/PDA antibacterial system exhibited more distinct antimicrobial activity against the resistant Gram-positive bacteria. The damage range of ROS generated by antibacterial nanozyme was optimized through the combination with nanomotor, which addressed the issue on limited bactericidal efficiency of traditional nanozymes, and showed great potential in the development of new generation of antibacterial nanoagents.
- Nanoenzyme,
- Nanomotor,
- Reactive oxygen species,
- Antimicrobial activity
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