Citation: LUO Xin, WANG Zhen-Ju, XIE Tang-Tang, DING You-Chao, TANG Zhi-Xu, YE Xi-Wen, NIU Zeng-Yuan. Non-Target Screening and Identification of Fluorescent Whitening Agents in Children Masks Based on High Resolution Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(11): 1926-1936. doi: 10.19756/j.issn.0253-3820.210525 shu

Non-Target Screening and Identification of Fluorescent Whitening Agents in Children Masks Based on High Resolution Mass Spectrometry

LUO Xin ^1,, ,
WANG Zhen-Ju ^1,2 ,
XIE Tang-Tang ³ ,
DING You-Chao ⁴ ,
TANG Zhi-Xu ¹ ,
YE Xi-Wen ¹ ,
NIU Zeng-Yuan ^1,,

1.
Technology Center of Qingdao Customs District, Qingdao 266109, China;
2.
College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China;
3.
The Testing and Technology Center for Industrial Products, Shenzhen Customs, Shenzhen 518000, China;
4.
Nanjing Customs District Industrial Products Inspection Center, Nanjing 210001, China

Corresponding author: LUO Xin, NIU Zeng-Yuan,
Received Date: 26 May 2021
Revised Date: 10 September 2021

Fund Project: Supported by the National Key R&D Program of China (No.2016YFF0203702) and Research Project of General Administration of Customs, P.R. China (No.2019HK070).

Fluorescent whitening agents (FWAs) are a class of fluorescent dyes with whitening effects, and are widely used in textiles, paper, detergents, cosmetics, plastic toys, food contact materials and other products. In view of their harm to people and the environment, FWAs are limited by relevant regulations at home and abroad. In this work, based on high performance liquid chromatography-high resolution mass spectrometry technique, a method was established for non-targeted screening and identification of 31 kinds of FWAs, which belonged to 7 different classes, in children's masks. And the method was successfully applied to the analysis of real masks samples from 18 different brands. Using methanol:water (3:1, V/V) solution as extraction solvent, the FWAs in children's masks were extracted by ultrasonic assisted extraction. For chromatographic separation, 5 mmol/L ammonium acetate and methanol were used as the mobile phase and the gradient elution was optimized. A Full mass scan and data-dependent MS/MS mode (Full MS/dd-MS²) was used for high-resolution mass spectrometry detection. Qualitative confirmation of compounds was based on multi-dimensional information, such as exact mass, parent ion isotope abundance ratio, predicted retention time and predicted fragment ion. The fragment structures of 4 kinds of FWAs detected in children's masks were firstly deduced by Xcalibur, Mass Frontier and ACD/MS Fragmenter software, and then compared with literature reports. Finally, the accurate qualitative and quantitative analyses were carried out by the reference standard materials of FWAs, and the methodological verification of the non-targeting method was carried out by using representative compounds. The established non-target screening method could achieve rapid analysis of FWAs with high throughput, without purchasing all reference standards and complicated method development. The method could satisfy both the regulations requirements and identification of non-target compounds. Especially during the epidemic period, it could provide an effective technical support for the quality control of masks and the protection of children's health.
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