Citation: LI Ping, XU Wen-Hui, ZHANG Da-Wei, JIA Qiong. Application of Lectin Affinity Methods in Analysis and Detection of Glycoprotein Cancer Biomarkers[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(9): 1451-1460. doi: 10.19756/j.issn.0253-3820.210435 shu

Application of Lectin Affinity Methods in Analysis and Detection of Glycoprotein Cancer Biomarkers

College of Chemistry, Jilin University, Changchun 130012, China

Corresponding author: ZHANG Da-Wei, JIA Qiong,
Received Date: 13 April 2021
Revised Date: 22 June 2021

Fund Project: Supported by Natural Science Foundation of Science and Technology Department of Jilin Province (No.201902010079JC).

Glycoproteins play an important role in regulating various physiological processes of organisms. Abnormal protein glycosylation is usually associated with the formation and evolution of diseases such as cancer. Many specific glycoproteins can be used as the biomarkers for early cancer diagnosis or prognosis monitoring. Before identifying the glycoproteins with mass spectrometry, effective separation and enrichment of glycoproteins from complex biological samples is a necessary step. Lectins are selective for certain specific glycoproteins, and lectin affinity methods have been widely used in the separation and enrichment of glycoprotein. By taking the four kinds of cancers (breast cancer, lung cancer, colorectal cancer and prostate cancer) with the highest incidence as examples, this article reviews the applications of lectin affinity methods integrated with mass spectrometry in screening and analyzing cancer biomarkers.
- Lectin,
- Glycoprotein,
- Cancer,
- Biomarker,
- Review
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