Citation: CUI Lin, WANG Peng-Yu, WANG Cheng-Ming, ZHANG Chun-Yang. Advance in Applications of Organic Polymer-based Electrochemiluminescence in Biochemical Analysis[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(5): 665-675. doi: 10.19756/j.issn.0253-3820.201722 shu

Advance in Applications of Organic Polymer-based Electrochemiluminescence in Biochemical Analysis

College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China

Corresponding author: ZHANG Chun-Yang, cyzhang@sdnu.edu.cn
Received Date: 3 December 2020
Revised Date: 26 February 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos.21735003, 21527811, 21605096, 21974080).

Electrochemiluminescence (ECL) is the process of producing species on the surface of electrodes and the subsequent formation of excited luminescence through electron transfer reaction. Organic polymeric materials are constructed by one or more molecules/molecular groups (structural units or monomers) which are covalently bonded to form multiple repeating monomer units. Organic polymers include metal-organic frameworks (MOFs), metal-organic gels (MOGs), conjugated microporous polymers (CMPs) and polymer dots (Pdots). In comparison with the cadmium-containing quantum dots, organic polymer materials have significant advantages including low toxicity and good biocompatibility, and they not only function as the ECL emitter, but also enhance the ECL signal. The organic polymer-based ECL sensors are characterized by good selectivity, high specificity, simple equipment, stable signal, easy measurement, high sensitivity, wide dynamic range, and low background, and they are widely applied to environmental monitoring, immunoassay, and nucleic acids analysis. This review summarizes the recent advance in applications of organic polymer-based ECL sensors in biochemical analysis, and focuses on the selective detection of metal ions, small biological molecules, nucleic acids, and proteins. In addition, we highlight the challenges and trends in the development of organic polymer-based ECL sensors.
- Organic polymer,
- Electrochemiluminescence,
- Biosensors,
- Bioanalysis,
- Review
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
10. [10]
11. [11]
12. [12]
13. [13]
14. [14]
15. [15]
16. [16]
17. [17]
18. [18]
19. [19]
20. [20]
21. [21]
22. [22]
23. [23]
24. [24]
25. [25]
26. [26]
27. [27]
28. [28]
29. [29]
30. [30]
31. [31]
32. [32]
33. [33]
34. [34]
35. [35]
36. [36]
37. [37]
38. [38]
39. [39]
40. [40]
41. [41]
42. [42]
43. [43]
44. [44]
45. [45]
46. [46]
47. [47]
48. [48]
49. [49]
50. [50]
51. [51]
52. [52]
53. [53]
54. [54]
55. [55]
56. [56]
57. [57]
58. [58]
59. [59]
60. [60]
61. [61]
62. [62]
63. [63]
64. [64]
1. [1]
  Cun WANG , Shaohan XU , Yuqian ZHANG , Yaoyao ZHANG , Tao GONG , Rong WEN , Yuhang LIAO , Yanrong REN . Terbium complex electrochemiluminescent emitters: Synthesis and application in the detection of epinephrine. Chinese Journal of Inorganic Chemistry, 2025, 41(7): 1351-1360. doi: 10.11862/CJIC.20240427
2. [2]
  Yang Meiqing , Lu Wang , Haozi Lu , Yaocheng Yang , Song Liu . Recent Advances of Functional Nanomaterials for Screen-Printed Photoelectrochemical Biosensors. Acta Physico-Chimica Sinica, 2025, 41(2): 100018-0. doi: 10.3866/PKU.WHXB202310046
3. [3]
  Lin′an CAO , Dengyue MA , Gang XU . Research advances in electrically conductive metal-organic frameworks-based electrochemical sensors. Chinese Journal of Inorganic Chemistry, 2025, 41(10): 1953-1972. doi: 10.11862/CJIC.20250160
4. [4]
  Gengjia Chen , Junjie Ou . Application of the van Deemter Equation in Instrumental Analysis Teaching: A Case of Organic Polymer Monolithic Columns. University Chemistry, 2025, 40(11): 362-368. doi: 10.12461/PKU.DXHX202502003
5. [5]
  Jiarong Feng , Yejie Duan , Chu Chu , Dezhen Xie , Qiu'e Cao , Peng Liu . Preparation and Application of a Streptomycin Molecularly Imprinted Electrochemical Sensor: A Suggested Comprehensive Analytical Chemical Experiment. University Chemistry, 2024, 39(8): 295-305. doi: 10.3866/PKU.DXHX202401016
6. [6]
  Xingchao Zhao , Xiaoming Li , Ming Liu , Zijin Zhao , Kaixuan Yang , Pengtian Liu , Haolan Zhang , Jintai Li , Xiaoling Ma , Qi Yao , Yanming Sun , Fujun Zhang . Photomultiplication-Type All-Polymer Photodetectors and Their Applications in Photoplethysmography Sensor. Acta Physico-Chimica Sinica, 2025, 41(1): 100007-0. doi: 10.3866/PKU.WHXB202311021
7. [7]
  Tianyun Chen , Ruilin Xiao , Xinsheng Gu , Yunyi Shao , Qiujun Lu . Synthesis, Crystal Structure, and Mechanoluminescence Properties of Lanthanide-Based Organometallic Complexes. University Chemistry, 2024, 39(5): 363-370. doi: 10.3866/PKU.DXHX202312017
8. [8]
  Jia-He Li , Yu-Ze Liu , Jia-Hui Ma , Qing-Xiao Tong , Jian-Ji Zhong , Jing-Xin Jian . 洛芬碱衍生物的合成、化学发光与重金属离子检测. University Chemistry, 2025, 40(6): 230-237. doi: 10.12461/PKU.DXHX202407080
9. [9]
  Wei Li , Jinfan Xu , Yongjun Zhang , Ying Guan . 共价有机框架整体材料的制备及食品安全非靶向筛查应用——推荐一个仪器分析综合化学实验. University Chemistry, 2025, 40(6): 276-285. doi: 10.12461/PKU.DXHX202406013
10. [10]
  Bao Jia , Yunzhe Ke , Shiyue Sun , Dongxue Yu , Ying Liu , Shuaishuai Ding . Innovative Experimental Teaching for the Preparation and Modification of Conductive Organic Polymer Thin Films in Undergraduate Courses. University Chemistry, 2024, 39(10): 271-282. doi: 10.12461/PKU.DXHX202404121
11. [11]
  Qiaoqiao BAI , Anqi ZHOU , Xiaowei LI , Tang LIU , Song LIU . Construction of pressure-temperature dual-functional flexible sensors and applications in biomedicine. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2259-2274. doi: 10.11862/CJIC.20240128
12. [12]
  Zhenli Sun , Ning Wang , Kexin Lin , Qin Dai , Yufei Zhou , Dandan Cao , Yanfeng Dang . Visual Analysis of Hotspots and Development Trends in Analytical Chemistry Education Reform. University Chemistry, 2024, 39(11): 57-64. doi: 10.12461/PKU.DXHX202403095
13. [13]
  Wenhui Li , Changshuo Zhu , Xinyu Cui , Chenfei Zhao , Lina Qiu , Yan Li , Chuandong Wu , Min Yang , Yuan Zhuang . Visual Determination of Acid-Base Titration Endpoints Using Smartphone APP-Based Analysis. University Chemistry, 2025, 40(7): 328-335. doi: 10.12461/PKU.DXHX202409062
14. [14]
  Lina Feng , Guoyu Jiang , Xiaoxia Jian , Jianguo Wang . Application of Organic Radical Materials in Biomedicine. University Chemistry, 2025, 40(4): 253-260. doi: 10.12461/PKU.DXHX202405171
15. [15]
  Zhongxin YU , Wei SONG , Yang LIU , Yuxue DING , Fanhao MENG , Shuju WANG , Lixin YOU . Fluorescence sensing on chlortetracycline of a Zn-coordination polymer based on mixed ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2415-2421. doi: 10.11862/CJIC.20240304
16. [16]
  Fang Mi , Furong Zhang , Zuotao Xu , Yushan Liu , Ming Guan . Visual Analysis of Dynamic Evolution and Development Trend of Analytical Chemistry Teaching Mode Research. University Chemistry, 2025, 40(9): 318-325. doi: 10.12461/PKU.DXHX202506072
17. [17]
  Yongjian Zhang , Fangling Gao , Hong Yan , Keyin Ye . Electrochemical Transformation of Organosulfur Compounds. University Chemistry, 2025, 40(5): 311-317. doi: 10.12461/PKU.DXHX202407035
18. [18]
  Zhilei Yin , Xinyu Song , Xuan Sun , Zhao Jin , Jin Zhang , Xuemei Ma , Bin Ge , Qisheng Song . Analysis of Inorganic and Analytical Chemistry Experiment in the 13th National Undergraduate Chemistry Experiment Competition Finals. University Chemistry, 2025, 40(11): 416-420. doi: 10.12461/PKU.DXHX202412138
19. [19]
  Tiantian MA , Sumei LI , Chengyu ZHANG , Lu XU , Yiyan BAI , Yunlong FU , Wenjuan JI , Haiying YANG . Methyl-functionalized Cd-based metal-organic framework for highly sensitive electrochemical sensing of dopamine. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 725-735. doi: 10.11862/CJIC.20230351
20. [20]
  Huiying Xu , Minghui Liang , Zhi Zhou , Hui Gao , Wei Yi . Application of Quantum Chemistry Computation and Visual Analysis in Teaching of Weak Interactions. University Chemistry, 2025, 40(3): 199-205. doi: 10.12461/PKU.DXHX202407011

Get Citation

PDF

XML

Metrics

PDF Downloads(16)
Abstract views(1254)
HTML views(237)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142