Citation: ZOU Hong-Yan, GUO Qing-Juan, HUANG Cheng-Zhi. Polydopamine-embedded Nonstoichiometric Copper Chalcogenide Nanoparticles for Chemotherapy-Photothermal Synergistic Therapy against Cancer Cells[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(7): 1228-1236. doi: 10.19756/j.issn.0253-3820.201570 shu

Polydopamine-embedded Nonstoichiometric Copper Chalcogenide Nanoparticles for Chemotherapy-Photothermal Synergistic Therapy against Cancer Cells

1.
Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;
2.
Key Laboratory of Luminescent and Real-Time Analytical System, Chongqing Science and Technology Bureau, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China

Corresponding author: HUANG Cheng-Zhi, chengzi@swu.edu.cn
Received Date: 22 September 2020
Revised Date: 29 March 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 21535006, 21705130) and the General Program of Chongqing Natural Science Foundation (No. cstc2020jcyj-msxmX0873)

Developing multifunctional nanomaterials is a hot topic for the combination therapy of tumor cells. In this work, a distinctive multifunctional composite (FA-Cu_2-xS_ySe_1-y@pDA-BTZ) was fabricated by assembling folic acid (FA) and the anticancer drug bortezomib (BTZ) to the surface of the nonstoichiometric copper chalcogenide nanoparticle (Cu_2-xS_ySe_1-y NPs) with typical localized surface plasmon resonance (LSPR) in the near-infrared region coated by polydopamine (Cu_2-xS_ySe_1-y@pDA). The FA-Cu_2-xS_ySe_1-y@pDA-BTZ showed a good light harvest in the second near-infrared window for bio-application and the photothermal conversion efficiency could reach 30.8%. FA was attached to the surface of the Cu_2-xS_ySe_1-y@pDA, so that the nanocomplex could be specifically delivered into cancer cells with overexpressed folate receptor. Meanwhile, BTZ could easily bind with Cu_2-xS_ySe_1-y@pDA through the formation of pH-responsive boronate ester bond between boronic acid and catechol groups in polydopamine under weakly alkaline conditions. Under 1064 nm laser irradiation in weakly acidic phosphate buffer, the controlled release of drugs was obtained. Under the laser irradiation (1064 nm), the relative survival rate of the cells was lower than 10%, which could realize the synergistic treatment of photothermal therapy and chemotherapy for tumor cells. The FA-Cu_2-xS_ySe_1-y@pDA-BTZ could be used as a new probe in the dark-field imaging for monitoring the therapy. The above results showed that the synthesized FA-Cu_2-xS_ySe_1-y@pDA-BTZ multifunctional composite had a good application prospect in the diagnosis and treatment of cancer.
1. [1]
  COUGHLAN C, IBÁÑEZ M, DOBROZHAN O, SINGH A, CABOT A, RYAN K M. Chem. Rev., 2017, 117(9): 5865-6109.
2. [2]
  LIU M X, LIU Y, GU B B, WEI X B, XU G X, WANG X M, SWIHART M T, YONG K T. Chem. Soc. Rev., 2019, 48(19): 4950-4965.
3. [3]
  XU W, LIU H C, ZHOU D, CHEN X, DING N, SONG H W, ÅGREN H. Nano Today, 2020, 33: 100892.
4. [4]
  ZHAO Y X, PAN H C, LOU Y B, QIU X, ZHU J, BURDA C. J. Am. Chem. Soc., 2009, 131(12): 4253-4261.
5. [5]
  MAITI S, KHAN A H, WOLF A, DORFS D, MOREELS I, SCHREIBER F, SCHEELE M. Chem. Mater., 2019, 31(7): 2443-2449.
6. [6]
  LIU M L, CHEN B B, LI R S, LI C M, ZOU H Y, HUANG C Z. ACS Sustain. Chem. Eng., 2017, 5(5): 4154-4160.
7. [7]
  YANG L, GAO M X, ZOU H Y, LI Y F, HUANG C Z. Anal. Chem., 2018, 90(19):11728-11733.
8. [8]
  ZOU H Y, WANG Q, YANG T, GAO P F, LIC M, HUANG C Z. Sens. Actuators, B, 2018, 262: 966-973.
9. [9]
  ZHU H, WANG Y, CHEN C, MA M R, ZENG J F, LI S Z, XIA Y S, GAO M Y. ACS Nano, 2017, 11(8): 8273-8281.
10. [10]
  DINGX G, FU D D, KUANG Y, ZOUY, YANG X Z, FENG L Z, SUN X, WU, H Y, JIANG J. ACS Appl. Nano Mater., 2018, 1(7): 3303-3311.
11. [11]
  LI X, YANG L, MEN C, XIE Y F, LIU, J J, ZOU H Y, LI Y F, ZHAN L, HUANG C Z. Anal. Chem., 2019, 91(7): 4444-4450.
12. [12]
  LIU Y, ZHU D, HU Y, SWIHART M T, WEI W. Langmuir, 2018, 34(46):13905-13909.
13. [13]
  GUAN G, WANG X, HUANG X, ZHANG W, CUI Z, ZHANG Y, LU X, ZOU R, HU J. Nanoscale, 2018, 10(26): 14190-14200.
14. [14]
  CUI J B, JIANG R, GUO C, BAI X L, XU S Y, WANG L Y. J. Am. Chem. Soc., 2018, 140(18): 5890-5894.
15. [15]
  HUANG Q, ZHANG S H, ZHANG H, HAN Y B, LIU H H, REN F, SUN Q, LI Z, GAO M Y. ACS Nano, 2019, 13(2): 1342-1353.
16. [16]
  CHENG H, ZHANG H Q, XU G J, PENG J, WANG Z, SUN B, AOUAMEUR D, FAN Z C, JIANG W X, ZHOU J P, DING Y. Nano-Micro Lett., 2020, 12(1): 155.
17. [17]
  SU J, CHEN F, CRYNS V L, MESSERSMITH P B. J. Am. Chem. Soc., 2011, 133(31): 11850-11853.
18. [18]
  HESSEL C M, PATTANI V P, RASCH M, PANTHANI M G, KOO B, TUNNLL J W, KORGEL B A. Nano Lett., 2011, 11(6): 2560-2566.
19. [19]
  ALIFU N, ZEBIBULA A, QI J, ZHANG H, SUN C, YU X, XUE D, LAM J W Y, LI G, QIAN J, TANG B Z. ACS Nano, 2018, 12(11): 11282-11293.
1. [1]
  Jiahui CHEN , Tingting ZHENG , Xiuyun ZHANG , Wei LÜ . Research progress of near-infrared absorption inorganic nanomaterials in photothermal and photodynamic therapy of tumors. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2396-2414. doi: 10.11862/CJIC.20240106
2. [2]
  Peng GENG , Guangcan XIANG , Wen ZHANG , Haichuang LAN , Shuzhang XIAO . Hollow copper sulfide loaded protoporphyrin for photothermal-sonodynamic therapy of cancer cells. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1903-1910. doi: 10.11862/CJIC.20240155
3. [3]
  Xue Wu , Yupeng Liu , Bingzhe Wang , Lingyun Li , Zhenjian Li , Qingcheng Wang , Quansheng Cheng , Guichuan Xing , Songnan Qu . Rationally assembling different surface functionalized carbon dots for enhanced near-infrared tumor photothermal therapy. Acta Physico-Chimica Sinica, 2025, 41(9): 100109-0. doi: 10.1016/j.actphy.2025.100109
4. [4]
  Qi Wang , Yicong Gao , Feng Lu , Quli Fan . Preparation and Performance Characterization of the Second Near-Infrared Phototheranostic Probe: A New Design and Teaching Practice of Polymer Chemistry Comprehensive Experiment. University Chemistry, 2024, 39(11): 342-349. doi: 10.12461/PKU.DXHX202404141
5. [5]
  Di WU , Ruimeng SHI , Zhaoyang WANG , Yuehua SHI , Fan YANG , Leyong ZENG . Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135
6. [6]
  Zhuoya WANG , Le HE , Zhiquan LIN , Yingxi WANG , Ling LI . Multifunctional nanozyme Prussian blue modified copper peroxide: Synthesis and photothermal enhanced catalytic therapy of self-provided hydrogen peroxide. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2445-2454. doi: 10.11862/CJIC.20240194
7. [7]
  Anbang Du , Yuanfan Wang , Zhihong Wei , Dongxu Zhang , Li Li , Weiqing Yang , Qianlu Sun , Lili Zhao , Weigao Xu , Yuxi Tian . Photothermal Microscopy of Graphene Flakes with Different Thicknesses. Acta Physico-Chimica Sinica, 2024, 40(5): 2304027-0. doi: 10.3866/PKU.WHXB202304027
8. [8]
  Wenjing ZHANG , Xiaoqing WANG , Zhipeng LIU . Recent developments of inorganic metal complex-based photothermal materials and their applications in photothermal therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2356-2372. doi: 10.11862/CJIC.20240254
9. [9]
  Weikang Wang , Yadong Wu , Jianjun Zhang , Kai Meng , Jinhe Li , Lele Wang , Qinqin Liu . Green H₂O₂ synthesis via melamine-foam supported S-scheme Cd_0.5Zn_0.5In₂S₄/S-doped carbon nitride heterojunction: synergistic interfacial charge transfer and local photothermal effect. Acta Physico-Chimica Sinica, 2025, 41(8): 100093-0. doi: 10.1016/j.actphy.2025.100093
10. [10]
  Ruifeng CHEN , Chao XU , Jianting JIANG , Tianshe YANG . Gold nanorod/zinc oxide/mesoporous silica nanoplatform: A triple-modal platform for synergistic anticancer therapy. Chinese Journal of Inorganic Chemistry, 2025, 41(11): 2272-2282. doi: 10.11862/CJIC.20250117
11. [11]
  Shiyang He , Dandan Chu , Zhixin Pang , Yuhang Du , Jiayi Wang , Yuhong Chen , Yumeng Su , Jianhua Qin , Xiangrong Pan , Zhan Zhou , Jingguo Li , Lufang Ma , Chaoliang Tan . Pt Single-Atom-Functionalized 2D Al-TCPP MOF Nanosheets for Enhanced Photodynamic Antimicrobial Therapy. Acta Physico-Chimica Sinica, 2025, 41(5): 100046-0. doi: 10.1016/j.actphy.2025.100046
12. [12]
  Weihan Zhang , Menglu Wang , Ankang Jia , Wei Deng , Shuxing Bai . Surface Sulfur Species Influence Hydrogenation Performance of Palladium-Sulfur Nanosheets. Acta Physico-Chimica Sinica, 2024, 40(11): 2309043-0. doi: 10.3866/PKU.WHXB202309043
13. [13]
  Liuyun Chen , Wenju Wang , Tairong Lu , Xuan Luo , Xinling Xie , Kelin Huang , Shanli Qin , Tongming Su , Zuzeng Qin , Hongbing Ji . Soft template-induced deep pore structure of Cu/Al₂O₃ for promoting plasma-catalyzed CO₂ hydrogenation to DME. Acta Physico-Chimica Sinica, 2025, 41(6): 100054-0. doi: 10.1016/j.actphy.2025.100054
14. [14]
  Yongjie ZHANG , Bintong HUANG , Yueming ZHAI . Research progress of formation mechanism and characterization techniques of protein corona on the surface of nanoparticles. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2318-2334. doi: 10.11862/CJIC.20240247
15. [15]
  Tingting XU , Wenjing ZHANG , Yongbo SONG . Research advances of atomic precision coinage metal nanoclusters in tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2275-2285. doi: 10.11862/CJIC.20240229
16. [16]
  Jie WEI , Qing ZHOU , Dandan DING , Xiang JING , Fei LI . Photothermal toxicity of Prussian blue nanoparticles to cervical cancer cells. Chinese Journal of Inorganic Chemistry, 2025, 41(11): 2345-2357. doi: 10.11862/CJIC.20240435
17. [17]
  Yanxi LIU , Mengjia XU , Haonan CHEN , Quan LIU , Yuming ZHANG . A fluorescent-colorimetric probe for peroxynitrite-anion-imaging in living cells. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1112-1122. doi: 10.11862/CJIC.20240423
18. [18]
  Tieping CAO , Yuejun LI , Dawei SUN . Surface plasmon resonance effect enhanced photocatalytic CO₂ reduction performance of S-scheme Bi₂S₃/TiO₂ heterojunction. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 903-912. doi: 10.11862/CJIC.20240366
19. [19]
  Hong LI , Xiaoying DING , Cihang LIU , Jinghan ZHANG , Yanying RAO . Detection of iron and copper ions based on gold nanorod etching colorimetry. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 953-962. doi: 10.11862/CJIC.20230370
20. [20]
  Tiejin Chen , Xiaokuang Xue , Jian Li , Minhui Cui , Yongliang Hao , Mianqi Xue , Haihua Xiao , Jiechao Ge , Pengfei Wang . Membrane-anchoring nanoengineered carbon dots as a pyroptosis amplifier for robust tumor photodynamic-immunotherapy. Acta Physico-Chimica Sinica, 2025, 41(10): 100113-0. doi: 10.1016/j.actphy.2025.100113

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(964)
HTML views(106)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142