Citation: HE Fei-Yao, LIU Ze-Ping, DAI Jian-Xiong, LI Wen-Wen, GUO Xing, FU Yu, YUE Han-Lu, LI Hong, DENG Fu-Long, ZHAO Zhong-Jun, DUAN Yi-Xiang. Study on Transmission Characteristics of Radio Frequency Quadrupole Ion Guide for Proton Transfer Reaction Time-of-Flight Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(3): 359-365. doi: 10.19756/j.issn.0253-3820.201519 shu

Study on Transmission Characteristics of Radio Frequency Quadrupole Ion Guide for Proton Transfer Reaction Time-of-Flight Mass Spectrometry

HE Fei-Yao ¹ ,
LIU Ze-Ping ² ,
DAI Jian-Xiong ³ ,
LI Wen-Wen ⁴ ,
GUO Xing ³ ,
FU Yu ⁵ ,
YUE Han-Lu ¹ ,
LI Hong ¹ ,
DENG Fu-Long ¹ ,
ZHAO Zhong-Jun ^6,, ,
DUAN Yi-Xiang ^1,7,,

1.
College of Life Science, Sichuan University, Chengdu 610064, China;
2.
China Nuclear Xiapu Nuclear Power Co., Ltd, Ningde 355100, China;
3.
College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China;
4.
West China School of Public Health, Sichuan University, Chengdu 610064, China;
5.
School of Mechanical Engineering, Sichuan University, Chengdu 610064, China;
6.
School of Chemical Engineering, Sichuan University, Chengdu 610064, China;
7.
Aliben Science & Technology CO., LTD, Chengdu 610064, China

Corresponding author: ZHAO Zhong-Jun, DUAN Yi-Xiang,
Received Date: 27 August 2020
Revised Date: 20 December 2020

Fund Project: Special Project of Major Scientific Instruments and Equipment in Sichuan Province (No.2019ZDZX0036).

Radio frequency quadrupole ion guide (RF-QIG) is widely used in various mass spectrometry systems because of its simple structure and high transmission efficiency. In this study, the self-developed RF-QIG was successfully integrated into the proton transfer reaction time-of-flight mass spectrometry (PTR-TOF MS). Through the adjustment of variable radio frequency electric field, the transmission characteristics of the device in ions with different mass-charge ratio (m/z) at different operating frequencies and voltage amplitudes were investigated. The results showed that when the frequency was less than 1 MHz, the RF-QIG reported here couldn't transport ions with m/z less than 40, while H₃O⁺ (m/z 19) and H₂O·H₃O⁺ (m/z 37) could obtain strong MS signals at 2.48 MHz and 3.43 MHz. In addition, for the ions with higher m/z, such as[C₃H₆O+H]⁺ (m/z 59),[C₆H₆+H]⁺ (m/z 79) and[C₇H₈+H]⁺ (m/z 93), the strongest signals were all obtained at 2.48 MHz. The results of MATLAB's numerical solution of the effective potential showed that when the voltage amplitude was constant, the higher the frequency was given, the lower the effective potential was obtained. Finally, the successful detection of the background air in the laboratory showed that RF-QIG could be used in the ion transportation of PTR-TOF MS system.
- Ion guide,
- Radio frequency quadrupole,
- Proton transfer reaction mass spectrometer,
- Time-of-flight mass spectrometry
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