Citation: CUI Lin, ZHAO Min-Hui, ZHANG Chun-Yang. Recent Advance in Applications of Host-Guest Interaction in Biochemical Analysis[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(7): 817-826. doi: 10.19756/j.issn.0253-3820.201090 shu

Recent Advance in Applications of Host-Guest Interaction in Biochemical Analysis

College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China

Received Date: 20 February 2020
Revised Date: 29 April 2020

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21735003, 21527811, 21605096, 21974080) and the Award for Team Leader Program of Taishan Scholars of Shandong Province, China.

Host-guest interaction is the process in which the host selectively combines the guest to form a supramolecular with specific function through non-covalent bonding according to the principles of structural complementarity and energy matching. The identification of biomolecules through antigen-antibody, DNA-protein, enzyme-substrate interactions in biological systems is based on the recognition of non-covalent interactions. The host-guest interaction possesses distinct characteristics of mild reaction conditions and dynamic reversible reaction process, and it not only can efficiently overcome the limitations of covalent bonding, but also can simulate the biological functions at the molecular level. This review summarizes the advance in the applications of host-guest interaction in biochemical analysis including the detection of proteins, nucleic acids, small biological molecules, metal ions and isomers. In addition, the challenges and trends in the development of biosensors based on host-guest interaction are highlighted.
- Host-guest interaction,
- Biosensors,
- Biochemical analysis,
- Sensitive detection,
- Review
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