Citation: WANG Yu-Fen, LU Hai-Yan, ZHANG Hua, CHEN Huan-Wen. Research Progress on Tissue Analysis by Mass Spectrometry without Sample Pretreatment[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(7): 827-837. doi: 10.19756/j.issn.0253-3820.191704 shu

Research Progress on Tissue Analysis by Mass Spectrometry without Sample Pretreatment

1.
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130012, China;
2.
Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China Institute of Technology, Nanchang 330013, China

Received Date: 30 November 2019
Revised Date: 10 January 2020

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21565004, 21605016, 21765001) and the Natural Science Foundation of Jiangxi Province, China (No.20171ACG70015).

Tissue samples contain abundant biological molecular information, which is widely used for the study of metabolomics, lipidomics and proteomics. Ambient mass spectrometry (AMS) has the ability to directly obtain the information of tissue samples, including the kind and content of biomolecules. Moreover, it has many advantages such as high sensitivity, high throughput, and low consumption, etc. Recently, AMS has been increasingly applied in analyzing various tissue samples. In this paper, the applications of AMS in plant, animal and postoperative tissue samples in recent years were reviewed. Furthermore, the challenges and prospects of analyzing tissue samples by ambient mass spectrometry imaging were briefly discussed.
- Ambient mass spectrometry,
- Tissue samples,
- Mass spectrometry imaging,
- Review
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