Citation: HE Ruo-Xi, WANG Qi, LI Bei, JIA Jing, LU Wen-Jing, SHUANG Shao-Min. Construction of Protein-mediated Copper Sulfide Bonded Mesoporous Silica Nanoparticles Vector for Chemo-photothermal Synergistic Therapy of Cancer[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(2): 197-205. doi: 10.19756/j.issn.0253-3820.191615 shu

Construction of Protein-mediated Copper Sulfide Bonded Mesoporous Silica Nanoparticles Vector for Chemo-photothermal Synergistic Therapy of Cancer

School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China

Received Date: 19 October 2019
Revised Date: 21 November 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21874087).

Bovine serum albumin-mediated copper sulfide nanocomplex (BSA/CuS) was modified on mesoporous silica (MSN) loaded with chemotherapeutic drug doxorubicin (DOX) by amide bond to prepare a new drug carrier, MSN-DOX@BSA/CuS. The disulfide bond of blocking agent BSA would break down after redox reaction with glutathione, resulting in MSN pore exposure and release of DOX. CuS, as a photothermal reagent, could convert light energy into heat for photothermal therapy. UV-Vis-NIR absorption spectra were used to investigate the absorption properties of the carrier. The results showed that the carrier had strong absorption in the range of 800-1100 nm and could realize the photothermal conversion under the near infrared light. In addition, MSN@BSA/CuS was incubated with cancer cells and showed no cytotoxicity. When MSN-DOX@BSA/CuS was added, the relative survival rate of the cells decreased to 49%. After the extra laser, the cell viability was only 18%. The above results showed that the synthesized nano drug carrier could realize the synergistic treatment of photothermal therapy and chemotherapy at the same time, and effectively improved the treatment efficiency of cancer.
- Mesoporous silica nanoparticles,
- Bovine serum albumin,
- Copper sulfide,
- Chemotherapy and photothermal therapy,
- Synergistic therapy
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