Citation: JIN Jing, WU Fei, YU Ping, MAO Lan-Qun. Progress of Electrochemical Analysis and Imaging of Extracellular Space[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1512-1523. doi: 10.19756/j.issn.0253-3820.191468 shu

Progress of Electrochemical Analysis and Imaging of Extracellular Space

JIN Jing ^1,2, ,
WU Fei ^1,2 ,
YU Ping ^1,2 ,
MAO Lan-Qun ^1,2

1.
Beijing National Laboratory for Molecular Science, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 30 July 2019
Revised Date: 27 August 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos.21790390, 21790391, 21621062, 21874139) and the National Key Research and Develop Program of China (No. 2018YFE0200800).

Extracellular space (ECS) is the fluid-filled space surrounding the brain cells, accounting for about one fifth of brain volume. As an essential living environment for neurons and glial cells, ECS not only transports substances for cells, but also enables stable electrical signaling. Therefore, it is closely related to the basic functions of the brain, such as synaptic transmission, memory, sleep and diseases. This review focuses on the primary biophysical characteristics of ECS and the main progress on investigating volume fraction and tortuosity with electrochemical analysis and imaging methods. The review also expounds on the variation of ECS in physiological and pathological processes.
- Extracellular space,
- Electrochemical analysis,
- Imaging,
- Volume fraction,
- Tortuosity,
- Review
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