Citation: WEI Huan, WU Fei, YU Ping, MAO Lan-Qun. Advances in Electrochemical Biosensors for in Vivo Analysis[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1466-1479. doi: 10.19756/j.issn.0253-3820.191465 shu

Advances in Electrochemical Biosensors for in Vivo Analysis

WEI Huan ^1,2, ,
WU Fei ^1,2 ,
YU Ping ^1,2 ,
MAO Lan-Qun ^1,2

1.
Beijing National Laboratory for Molecular Science, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 30 July 2019
Revised Date: 27 August 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21790390, 21790391, 21621062, 21874139) and the National Key Research and Develop Program of China (No. 2018YFE0200800).

As the chemical species build the essential basis for mediating and modulating neurotransmission that determines various physiological and pathological states of the central nervous system (CNS), the fundamental research on neurochemistry, especially the investigation of the correlation between neurochemical dynamics and activities of vesicles, single cells, neural circuits and the entire brain, has attracted increasing attention due to its significance in understanding the brain function. Electrochemical analytical methods have made tremendous achievements for in vivo and online continuous monitoring of neurotransmitters and neuromodulators. Among them, the methods utilizing enzymes or aptamers as the biorecognition elements and rationally designing electrode surfaces/interfaces to construct the electrochemical biosensors with high selectivity and high sensitivity undoubtedly provide attractive approaches to quantitative monitoring of brain chemistry. This review mainly focuses on the recent advances in electrochemical biosensors for in vivo analysis.
- Electrochemical biosensors,
- In vivo analysis,
- Online electrochemical analysis,
- Brain chemistry,
- Review,
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