Citation: JI Wen-Liang, ZHANG Mei-Ning, MAO Lan-Qun. Recent Advances on in Vivo Electrochemical Analysis of Vitamin C In Rat Brain[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1559-1571. doi: 10.19756/j.issn.0253-3820.191463 shu

Recent Advances on in Vivo Electrochemical Analysis of Vitamin C In Rat Brain

1.
Department of Chemistry, Renmin University of China, Beijing 100872, China;
2.
Beijing National Laboratory for Molecular Science, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;
3.
University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 30 July 2019
Revised Date: 20 August 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21874152).

Vitamin C, also known as ascorbic acid, is an important neurochemicals in the brain. It serves as one of most important small-molecular-weight antioxidants for neuro-protection and neuromodulator to modulate neurological functions through glutamatergic, dopaminergic and neurotransmission. It is also a cofactor of enzymes involved in biosynthetic reactions such as the synthesis of catecholamines. Therefore, increasing interest has attracted in the measurement of AA in the brain. The high-potential oxidation of AA essentially renders difficulties in exploring the electrochemical property of AA to constitute an electrochemical protocol for its selective detection of AA with high spatial and temporal resolution in the brain. This review mainly focuses on recent updates on detection of AA by modulating the electron transfer of AA to achieve the high temporal, spatial resolution and selectivity for its detection in the rat brain and single-cell.
- Vitamin C,
- In vivo,
- Electrochemical analysis,
- Selectivity,
- Review
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