Citation: WEI Chun-Rong, PEI Wei-Hua. Development of Implantable Multichannel Nural Mcroelectrodes[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1455-1465. doi: 10.19756/j.issn.0253-3820.191430 shu

Development of Implantable Multichannel Nural Mcroelectrodes

WEI Chun-Rong ^1,2, ,
PEI Wei-Hua ¹

1.
The State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 22 July 2019
Revised Date: 3 September 2019

Fund Project: This work was supported by the National Key Technologies Research and Development Program (Nos. 2017YFA0205903, 2017YFA0701100, 2016YFB0402405), the National Natural Science Foundation of China (Nos. 61634006, 61671424), the Basic Research Project of Shanghai Science and Technology Commission (No. 16JC1400101), the Strategic Priority Research Program of Chinese Academy of Sciences Pilot Project (Nos. XDB32030100, XDB32040200), and the Key Programs of Chinese Academy of Sciences (No. QYZDY-SSW-JSC004).

The human brain contains about 80 billion nerve cells, and the connections between neurons form a complicated brain neural network. To study the function of the brain mechanisms and the coding principle of the neural network, an important method is to record single-neuron activity as much as possible at the same time. Implantable multichannel neural microelectrodes is a key device that multiple discharge activities of single neurons and can record the spike potential signal of neurons in real-time. In terms of the temporal resolution of neural signals, microelectrode has irreplaceable advantages over other neuroimaging techniques. How to implant more electrodes with more channels in the brain without affecting the function of the brain requires constant innovation and optimization in the material, structure, integration mode and packaging method of implanting multichannel electrodes. This paper briefly reviews the development history of multichannel microwire technology and focuses on the development history, research status and future development trend of implantable multichannel microelectrode by micromachining technology.
- Implantable neural microelectrodes,
- Micromachining technology,
- Multichannel microelectrodes,
- thin film electrode,
- Electrode array,
- Review
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