Citation: CHEN Zhong-Hui, CHEN Yu, WENG Ai-Bin, LUO Fang, GUO Long-Hua, QIU Bin, LIN Zhen-Yu, CHEN Guo-Nan. Research Progress of in Vivo Detection Methods for Gasotransmitter Hydrogen Sulfide[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(10): 1572-1579. doi: 10.19756/j.issn.0253-3820.191366 shu

Research Progress of in Vivo Detection Methods for Gasotransmitter Hydrogen Sulfide

CHEN Zhong-Hui ^1,2, ,
CHEN Yu ¹ ,
WENG Ai-Bin ¹ ,
LUO Fang ² ,
GUO Long-Hua ² ,
QIU Bin ² ,
LIN Zhen-Yu ² ,
CHEN Guo-Nan ²

1.
The Affiliated Hospital of Putian University, Putian University, Putian 351100, China;
2.
Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou 350116, China

Received Date: 27 June 2019
Revised Date: 14 August 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21775026).

The quantitative analysis for neurochemistry in living biosystems has drawn extensive attention, because the physiological active substance participates in the transmission of information and relates to physiology and pathology in the brain. Hydrogen sulfide (H₂S), as the third gasotransmitter, plays a significant role in the neurophysiology and neuropathology in brain. In vivo detection of H₂S will greatly promote the molecular mechanism in the physiology and pathology process. However, H₂S have strong reducibility and volatility, and its properties are similar to those of sulfhydryl compounds in the brain. Therefore, selective separation and recognition of H₂S from sulfhydryl compounds in the brain is the key scientific issue in the detection of H₂S. Herein, the design principle and research progress of various types of H₂S detection methods in recent year were reviewed, and an outlook for the future of H₂S detection method was propected.
- Hydrogen sulfide,
- In vivo detection methods,
- Review
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