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Citation: OU Shuo-Jun, CEN Jian-Bin, LIANG Jun-Fa, LI Xiu-Ying, GUO Xin-Dong, XUN Zhi-Qing, LUO Man-Ni, ZENG Guang-Feng. Determination of Seven Kinds of Alkylamines in Food Contact Plastic Materials by Amidation Coupled with High Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometer[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(3): 413-422. doi: 10.19756/j.issn.0253-3820.191049 shu

Determination of Seven Kinds of Alkylamines in Food Contact Plastic Materials by Amidation Coupled with High Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometer

1.
Guangzhou Customs Technology Center, Guangzhou Key Laboratory of Import and Export Technical Measures of Animal, Plant and Food, Guangzhou 510623, China;
2.
Guangzhou Inspection and Certification Group Co. Ltd., Guangzhou 511447, China;
3.
Guangzhou Quality Supervision and Testing Institute, Guangzhou 511447, China

Received Date: 21 January 2019
Revised Date: 26 November 2019

Fund Project: This work was supported by the Science and Technology Plan of General Administration of Quality Supervision, Inspection and Quarantine of the People`s Republic of China (No. 2015QK162).

A high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) method for determination of seven kinds of alkylamines was established. Samples were amidated with 0.4% benzyl chloroformate (Cbz-Cl) in acetonitrile-sodium carbonate solution (50:50, V/V). The amidated conditions, including concentration of sodium carbonate solution (1.5%, m/V), benzyl chloroformate ratio and amount of sodium chloride (1.5 g), were optimized by response surface methodology. Under the optimized chromatographic and mass spectrometer conditions, the data were collected with electrospray ionization (ESI) sources under positive ion mode. The calibration curves of seven kinds of alkylamines showed good linearity in concentration range of 1.0-500 μg/L(R²>0.9957). The average recoveries were 82.0%-108.0%, the limits of detection and quantification were 0.5-1.0 μg/kg and 2.0-4.0 μg/kg, respectively, and the relative standard deviations (RSDs) were 3.5%-6.8%. This method is efficient and easy to be operated, and has good sensitivity, high precision and accuracy in the determination of seven alkylamines in food contact plastic materials.
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