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Citation: LIU Jian-Hua, WANG Lei, ZHANG Tian-Qi, WANG Jian-Qiu, GONG Xue, CUI Feng-Zhi, ZHENG Jian-Jun, LI Bo, SHI Zhan. Facile Synthesis of Biocompatible Fe₃O₄-based Nanoparticles for pH-Responsive Dual-Model Magnetic Resonance Imaging- Guided Tumour Eradication by Photothermal Therapy[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(5): 678-685. doi: 10.19756/j.issn.0253-3820.191045 shu

Facile Synthesis of Biocompatible Fe₃O₄-based Nanoparticles for pH-Responsive Dual-Model Magnetic Resonance Imaging- Guided Tumour Eradication by Photothermal Therapy

LIU Jian-Hua ^1,2, ,
WANG Lei ² ,
ZHANG Tian-Qi ² ,
WANG Jian-Qiu ² ,
GONG Xue ² ,
CUI Feng-Zhi ² ,
ZHENG Jian-Jun ³ ,
LI Bo ² ,
SHI Zhan ¹

1.
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China;
2.
Department of Radiology, the Second Hospital of Jilin University, Changchun 130041, China;
3.
Department of Medical Imaging, Ningbo No.2 Hospital, Ningbo 315010, China

Received Date: 20 January 2019
Revised Date: 7 March 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No.81571737)

The early accurate diagnosis is key to the successful treatment of tumours. However, single magnetic resonance imaging (MRI) mode cannot satisfy the high requirement of accurate diagnosis owing to their inherent defects. Herein, we constructed poly(acrylic) acid (PAA)-modified Fe₃O₄@MnO₂ nanoparticles (Fe₃O₄@MnO₂@PAA NPs) as a kind of pH-responsive T₁/T₂ dual-model MRI guiding photothermal therapy (PTT). Fe₃O₄ core enabled Fe₃O₄@MnO₂@PAA NPs to weaken T₂ signal in clinical MRI examination, and MnO₂ nanoshells were able to decompose into paramagnetic manganous ions under the weakly acidic environment of tumours, achieving pH-responsive T₁-weighted MRI. Such pH-responsive T₁/T₂ dual-model CAs with sensitivity and specificity provided more comprehensive information for diagnosis of tumours. Moreover, Fe₃O₄@MnO₂@PAA NPs exhibited excellent absorption in near-infrared (NIR) region, making them as good NIR photothermal agents for PTT. This work presented novel pH-responsive theranostic agents integrated dual-model imaging and PTT functionalities, and demonstrated their potential for stimuli-responsive MRI guided PTT of cancer.
- Theranostic agents,
- Magnetic resonance imaging,
- Dual-model tumour imaging,
- Near-infrared region,
- Photothermal therapy
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Facile Synthesis of Biocompatible Fe₃O₄-based Nanoparticles for pH-Responsive Dual-Model Magnetic Resonance Imaging- Guided Tumour Eradication by Photothermal Therapy