Citation: XU Fu-Xing, CHEN Xin, CHEN Zhi-Yang, ZHOU Ming-Fei, DING Chuan-Fan. Dual-dircrtion Excitation Dissociation Technology in Digital Ion Ttrap[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(5): 702-708. doi: 10.19756/j.issn.0253-3820.191016 shu

Dual-dircrtion Excitation Dissociation Technology in Digital Ion Ttrap

1.
Department of Chemistry and Laser Chemistry Institute, Fudan University, Shanghai 200433, China;
2.
Department of Anesthesiology, Fudan University, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

Received Date: 8 January 2019
Revised Date: 18 March 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos.21803013, 21773035) and the China Postdoctoral Science Foundation (No. 2018M632002).

Tandem mass spectrometric analysis is one primary function of ion trap mass analyzer. In linear ion trap, this function is conducted by collision induced dissociation (CID), which is realized via applying dipolar excitation voltage on one couple of electrodes, so the CID method is also known as unidirectional ion excitation. In this work, bidirectional resonance excitation method was introduced. By applying dipolar excitation voltage on two couples of electrodes, the ion excitation energy and associated dissociation efficiency of this method were increased. The simulation and experimental results indicated that based on this method, higher ion dissociation efficiency was obtained with different q values and excitation frequencies. Besides, more small fragments could be detected in tandem mass analysis of leucine enkephalin via bidirectional resonance excitation with q=0.352, V=0.5 V_0-p, ω=107.93 kHz and t=5 ms, suggesting that the method could effectively decrease low mass cut-off effect and strength ability of ion trap on tandem mass analysis.
- Ion trap mass analyzer,
- Digital ion trap,
- Collision-induced dissociation,
- Dual-dircrtion excitation dissociation,
- Collision induced dissociation efficiency,
- Low mass cutoff
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沈阳化工大学材料科学与工程学院沈阳 110142