Citation: DU Rui, ZHANG Yu-Ling, ZENG Jia-Fa, FANG Ming-Liang, Sasho Gligorovski, ZHOU Zhen, LI Xue. Influence of Ambient Gases on Detection of Exhaled Gas in Secondary Electrospray Source by Ultra-High Resolution Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(6): 916-924. doi: 10.19756/j.issn.0253-3820.181584 shu

Influence of Ambient Gases on Detection of Exhaled Gas in Secondary Electrospray Source by Ultra-High Resolution Mass Spectrometry

DU Rui ^1,2, ,
ZHANG Yu-Ling ^1,2 ,
ZENG Jia-Fa ^1,2 ,
FANG Ming-Liang ³ ,
Sasho Gligorovski ⁴ ,
ZHOU Zhen ^1,2 ,
LI Xue ^1,2

1.
Institute of Mass Spectrometry and Atmospheric Environment, Jinan University, Guangzhou 510632, China;
2.
Guangdong Provincial Engineering Research Center for On-line Source Apportionment System of Air Pollution, Guangzhou 510632, China;
3.
School of Civil and Environmental Engineering, Nanyang Technological University, Singapore 637457, Singapore;
4.
Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510641, China

Received Date: 8 September 2018

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 91543117), Special Support Plan for High-Level Talents in Guangdong Province (No. 2016TQ03R103), Science and Technology Program of Guangzhou (No. 201804010114), and Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation ("Climbing Program" Special Funds) (No. Pdjh2018a0051).

The secondary electrospray ionization mass spectrometry (SESI-MS) has great potential in acquiring breathomics by in vivo, real-time and direct breath analysis. However, as an ambient source, the ionization efficiency of exhaled volatile organic compounds (VOCs) can be disturbed by the occurrence of indoor VOCs (background matrix) in SESI source. Therefore, we explored the effects of pure gases in the SESI source on the ionization efficiency of typical exhaled endogenous compounds, i.e., acetone and indole, as well as typical background matrix, i.e., phthalic anhydride (PA) and dibutyl phthalate (DP), by using a homemade SESI source coupled with an ultrahigh resolution mass spectrometer (UHRMS). The pure gases in this study included nitrogen (N₂, purity 99.999%), carbon dioxide (CO₂, purity 99.99%) and Zero air (VOCs free, 21% O₂ and 79% N₂ by volume). The results showed that the presence of all three pure gases could significantly increase the signal intensity and signal-to-noise ratio of exhaled acetone and indole. In contrast, the intensities of matrix interferences PA and DA decrease, because the concentrations of these compounds were diluted by the pure gases. Among three pure gases, the effect of N₂ was most significant. In summary, the results of this study provided helpful information for SESI source design and parameter setting, which was an important prerequisite for the development of qualitative and quantitative methods for the detection of exhaled VOCs by using SESI-MS.
- Breathomic,
- Direct mass spectrometry,
- Ultra-high resolution mass spectrometer,
- Secondary electrospray ionization,
- Ambient gas
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