Citation: SUN Bo-Lu, CAI Jin-Ying, LI Dai, GOU Xiao-Dan, GOU Yu-Qiang, LI Wen, HU Fang-Di. Fabrication of Electrochemical Sensor Modified with Porous Graphene for Determination of Trace Calycosin[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(2): 271-280. doi: 10.19756/j.issn.0253-3820.181574 shu

Fabrication of Electrochemical Sensor Modified with Porous Graphene for Determination of Trace Calycosin

SUN Bo-Lu ^1, ,
CAI Jin-Ying ¹ ,
LI Dai ¹ ,
GOU Xiao-Dan ² ,
GOU Yu-Qiang ³ ,
LI Wen ¹ ,
HU Fang-Di ¹

1.
School of Pharmacy, Lanzhou University, Lanzhou 730000, China;
2.
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210046, China;
3.
Lanzhou Military Command Center for Disease Prevention and Control, Lanzhou 730000, China

Received Date: 5 September 2018
Revised Date: 28 November 2018

Fund Project: This work was supported by the Major Science and Technology Project of Gansu Provincial Science and Technology Department (No. 17ZD2FA009), the Patent Conversion Project of Lanzhou Science and Technology Bureau (No. 2017-4-119), the Achievement Transformation Base Project of Lanzhou (No. 2016-2-80), the National Key Research and Development Program of China (No. 2018YFC1706300) and the National Traditional Chinese Medicine Standardization Project (No. ZYBZH-Y-GS-10).

The porous graphene (PG) with excellent structure was successfully prepared by a simple pyrolysis process, which was then applied to the construction of electrochemical sensor (PG@GCE) for detection of calycosin. The porous graphene was characterized by Raman spectroscopy, Fourier transform infrared spectroscopy, and scanning electron microscopy. Also, the electrochemical properties of the proposed sensors were characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), indicating that the sensor had relatively large specific surface area and higher electron transport rate. Based on all those characteristics, the PC@GCE sensor displayed a great response to calycosin, a traditional Chinese medicine (TCM) active ingredient. Under the optimized conditions, the sensors displayed a good linear relationship between the peak current and the calycosin concentration in the range of 1.8×10^-7-4.4×10^-5 mol/L with a detection limit of 5.8×10^-8 mol/L (S/N=3). This study provided a novel analytical method for trace detection of calycosin, and rapid identification of Radix Hedysari and Radix Astragali in biological samples. At the same time, it would also deepen the application of porous graphene in the field of pharmaceutical analysis.
- Porous graphene,
- Calycosin,
- Electrochemical sensor,
- Trace analysis
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