Citation: LIANG Cai-Yun, LIU Feng-Ping, ZHANG Cui-Zhong, ZHANG Zhen-Fa, WEI Yuan-Ling, PENG Jin-Yun. Electrochemical Determination of Kanamycin Sulfate Based on Copper Nanoparticle/Zinc Oxide/Graphene Modified Electrode[J]. Chinese Journal of Analytical Chemistry, ;2019, 47(5): 739-747. doi: 10.19756/j.issn.0253-3820.181532 shu

Electrochemical Determination of Kanamycin Sulfate Based on Copper Nanoparticle/Zinc Oxide/Graphene Modified Electrode

1.
Guangxi Normal University for Nationalities, Chongzuo 532200, China;
2.
Guangxi Colleges and Universities Key Laboratory Breeding Base of Chemistry of Guangxi Southwest Plant Resources, Chongzuo 532200, China

Received Date: 14 August 2018
Revised Date: 7 March 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (No.21465004), the Guangxi Youth Competence Improvement Project 2017 (No. 2017KY0832) and the Guangxi Normal University for Nationalities Funding Research Projects (No. 2018QN037).

A novel electrochemical sensor was prepared by electrodeposition of copper nanoparticles (CuNPs) on a zinc oxide/graphene (ZnO/GO) modified ITO electrode and applied to the determination of kanamycin sulfate (KANA). The morphology of material and modified electrodes was characterized by scanning electron microscope. With optimization of measurement conditions systematically, the result showed that the electrochemical response of KANA on CuNPs/ZnO/GO/ITO electrode was the largest when the number of electrodeposition scanning circles were 40 in 0.15 mol/L PBS (pH=6.5) solution. The mechanism of electrode reaction of KANA involved one electron process, and the effective area (0.482 cm²) of CuNPs/ZnO/GO/ITO electrode was 2.42 times as large as that of a bare ITO electrode. Moreover, the linear response range for determination of KANA was 0.99-30.6 μmol/L, the linear equation was I_pc=-5.183c-4.544×10^-6 with the detection limit of 0.31 μmol/L, and the recoveries of standard addition experiments were 97.8%-103.6%. The sensor shows good stability and reproducibility, and can be used to detect kanamycin sulfate in the drug samples.
- Zinc oxide/graphene,
- Copper nanoparticles,
- Modified electrode,
- Kanamycin sulfate
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1.
沈阳化工大学材料科学与工程学院沈阳 110142