Citation: Wei SU, Bao-Qu ZHANG, Bing-Hua PENG, Zhao-Feng TANG, Pei-Yuan LI. Synthesis and Anticancer Activity of a New Di-nuclear Ruthenium Arene Compound with Thiosemicarbazones[J]. Chinese Journal of Structural Chemistry, ;2020, 39(6): 1112-1118. doi: 10.14102/j.cnki.0254-5861.2011-2606 shu

Synthesis and Anticancer Activity of a New Di-nuclear Ruthenium Arene Compound with Thiosemicarbazones

a.
Key Laboratory of Guangxi Key Laboratory of Natural Polymer Chemistry and Physics (Nanning Normal University), Nanning 530001, China
b.
College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China

Corresponding author: Pei-Yuan LI, lipearpear@163.com
Received Date: 19 September 2019
Accepted Date: 13 January 2020

Fund Project: the National Natural Science Foundation of China 51961009the National Natural Science Foundation of China 21761006Natural Science Foundation of Guangxi Province 2017GXNSFAA198335Natural Science Foundation of Guangxi Province 2018GXNSFAA281345Guangxi Scientific and Technological Development Projects AD17195081"BAGUI Scholar" Program of Guangxi Province, Natural Science Foundation of Guangxi University of Chinese Medicine 2017JQ001Guangxi First-class Discipline: Chinese Materia Medica Scientific Research of Guangxi Education Department [2018] No. 12Research Project of Guangxi First-class Discipline 2019XK135Project of Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine GXZYZZ2019-4

Figures(5)

A new di-nuclear ruthenium arene compound containing thiosemicarbazone ligands, [Ru(η⁶-cymene)(TSC)Cl]₂(PF₆)₂ (2), was synthesized and characterized by ¹H NMR, HR-ESI-MS, and elemental analysis. Furthermore, the complete structure of 2 was determined by single-crystal X-ray diffraction analysis. Density functional theory (DFT) calculations with B3LYP functional and LANL2DZ (for Ru)/6-31G* (for other atoms) basis sets were carried out for the reactions involving complexes 1 and 2 in order to understand the formation of the complexes. The in vitro anticancer activities of the compound were investigated against five human cancer cell lines (SGC-7901, CNE-2, HepG2, KB and HeLa), and the IC₅₀ values are 39.5, 45.8, 49.8, 54.5 and 61.8 μM, respectively.
- ruthenium,
- compound,
- DFT,
- anticancer
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