Citation: Xiao-Bo WANG, Xiao-Qi YU, Xue-Lei HU. Synthesis, Crystal Structures, DNA Cleavage and DNA-binding Studies of Ho(Ⅲ) and Er(Ⅲ) Complexes Based on Macrocyclic Schiff Base[J]. Chinese Journal of Structural Chemistry, ;2020, 39(6): 1103-1111. doi: 10.14102/j.cnki.0254-5861.2011-2601 shu

Synthesis, Crystal Structures, DNA Cleavage and DNA-binding Studies of Ho(Ⅲ) and Er(Ⅲ) Complexes Based on Macrocyclic Schiff Base

Xiao-Bo WANG ^{a, b,,} ,
Xiao-Qi YU ^c ,
Xue-Lei HU ^a,,

a.
School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China
b.
School of Pharmacy, Hubei University of Science and Technology, Xianning, Hubei 437100, China
c.
Hubei Geological Research Laboratory, Wuhan 430034, China

Corresponding author: Xiao-Bo WANG, eas7on@163.com Xue-Lei HU, huxuelei@mail.wit.edu.cn
Received Date: 12 September 2019
Accepted Date: 5 December 2019

Fund Project: the Natural Science Foundation of Hubei Province 2018CFB323

Figures(5)

Two novel macrocyclic Schiff base complexes [LnL(PhCOO)(CH₃OH)](ClO₄)₂·(CH₃OH)₂ (Ln = Ho, 1; Ln = Er, 2), in which L denotes the macrocyclic ligand, were synthesized via condensation of 2, 6-diformyl-4-methyl-phenol and 1, 3-diamino-2-propanol by employing benzoate as the second ligand. Their crystal structures were determined by X-ray diffraction, which showed that both complexes belong to a monoclinic system with space group P2₁/c. The coordination polyhedron displayed a distorted bicapped trigonal prism with the coordination number of eight. Both complexes efficiently cleaved supercoiled DNA to its nicked circular form. The UV-vis absorption results and ethidium bromide (EB) fluorescence spectra indicated that the complexes bind to CT-DNA in an intercalative mode, with K_sq values to be 11830 and 10560, respectively.
- macrocyclic Schiff base,
- crystal structure,
- CT-DNA,
- pBR 322,
- fluorescence spectrum
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