Citation: Hua-Lin CHEN, Qi-Tong HUANG, Shi-Rong HU, Shu-Li TANG, Hao YANG, Zhan-Ming LI. Co₃O₄/reduced Graphene Oxide Composite as An Enhanced Material for Electrochemical Detection of Paracetamol in Human Serum[J]. Chinese Journal of Structural Chemistry, ;2020, 39(6): 1035-1043. doi: 10.14102/j.cnki.0254-5861.2011-2529 shu

Co₃O₄/reduced Graphene Oxide Composite as An Enhanced Material for Electrochemical Detection of Paracetamol in Human Serum

Hua-Lin CHEN ^a ,
Qi-Tong HUANG ^b ,
Shi-Rong HU ^a,, ,
Shu-Li TANG ^a ,
Hao YANG ^a ,
Zhan-Ming LI ^{c, d}

a.
College of Chemistry, Chemical Engineering and Environment, Minnan Normal University, Zhangzhou 363000, China
b.
College of Pharmacy, Gannan Medical University, Ganzhou 341000, China
c.
Department of Food Science, China Jiliang University, Hangzhou 310018, China
d.
Food Science and Technology Programme, Department of Chemistry, National University of Singapore, Singapore 117543, Singapore

Corresponding author: Shi-Rong HU, hushirong6666@163.com
Received Date: 2 July 2019
Accepted Date: 23 October 2019

Fund Project: the Education Bureau of the Fujian province projects JAT160302the Natural Science Foundation of Zhejiang province LQ17C200002the Talents' Start-up Fund of Gannan Medical University projects QD201825

Figures(9)

In this paper, we present a novel, reliable and sensitive electrochemical sensor for the determination of paracetamol based on hollow carbon Co₃O₄ nanosheets/reduced graphene oxide composite (Co₃O₄/r-GO). The Co₃O₄/r-GO was prepared via a rapid one-step microwave solvothermal process. Some series of techniques that included scanning electron microscopy, X-ray diffraction and Raman were carried out to characterize the morphology and structure of as-prepared materials. Most importantly, the developed electrochemical sensor exhibited a wide linear range of 0.05 to 900.0 μM and a low detection limit of 14.0 nM (S/N = 3) by using differential pulse voltammetry. Furthermore, the selectivity, repeatability, stability and practical applicability were further studied with satisfactory results.
- Co₃O₄ nanosheets,
- reduced graphene oxide,
- paracetamol,
- electrochemical sensor
1. [1]
  Bayram, E.; Akyilmaz, E. Development of a new microbial biosensor based on conductive polymer/multiwalled carbon nanotube and its application to paracetamol determination. Sensor. Actuat. B Chem. 2016, 233, 409−418. doi: 10.1016/j.snb.2016.04.029
2. [2]
  Luo, J.; Ma, Q.; Wei, W.; Zhu, Y.; Liu, R.; Liu, X. Y. Synthesis of water-dispersible molecularly imprinted electroactive nanoparticles for the sensitive and selective paracetamol detection. ACS Appl. Mater. Inter. 2016, 8, 21028−21038. doi: 10.1021/acsami.6b05440
3. [3]
  Wang, X.; Wu, Q. H.; Liu, A. M.; Rodríguez, J. L. Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro. Drug. Metab. 2017, 49, 395−437. doi: 10.1080/03602532.2017.1354014
4. [4]
  Ejaz, A.; Jeon, S. A highly stable and sensitive GO-XDA-Mn₂O₃ electrochemical sensor for simultaneous electrooxidation of paracetamol and ascorbic acid. Electrochim. Acta 2017, 245, 742−751. doi: 10.1016/j.electacta.2017.05.193
5. [5]
  Ko, J. W.; Shin, J. Y.; Kim, J. W.; Park, S. H.; Shin, N. R.; Lee, I. C.; Shin, I. S.; Moon, C. J.; Kim, S. H.; Kim, S. H.; Kim, J. C. Protective effects of diallyl disulfide against acetaminophen-induced nephrotoxicity: a possible role of CYP₂E₁ and NF-κB. Food Chem. Toxicol. 2017, 102, 156−165. doi: 10.1016/j.fct.2017.02.021
6. [6]
  Ali, N. W.; Abdelwahab, N. S.; Abdelrahman, M. M.; EL-Zeiny, B. A.; Tohamy, S. I. Validated univariateand multivariate spectrophotometric methods for determination of paracetamol, ascorbic acid and pseudoephedrine hydrochloride. Anal. Chem. Lett. 2016, 6, 706−717. doi: 10.1080/22297928.2016.1246199
7. [7]
  Liu, X. T.; Na, W. D.; Liu, H.; Su, X. G. Fluorescence turn-off-on probe based on polypyrrole/graphene quantum composites for selective and sensitive detection of paracetamol and ascorbic acid. Biosens. Bioelectron. 2017, 98, 222−226. doi: 10.1016/j.bios.2017.06.044
8. [8]
  Fernandes, T. A. P.; Aguiar, J. P.; Fernandes, I.; Pinto, J. F. Quantification of theophylline or paracetamol in milk matrices by high-performance liquid chromatography, journal of pharmaceutical analysis. J. Pharmaceut. Biomed. 2017, 7, 401−405.
9. [9]
  Cunha, R. R.; Ribeiro, M. M. A. C.; Munoz, R. A. A.; Richter, E. M. Fast determination of codeine, orphenadrine, promethazine, scopolamine, tramadol, and paracetamol in pharmaceutical formulations by capillary electrophoresis. J. Sep. Sci. 2017, 40, 1815−1823. doi: 10.1002/jssc.201601275
10. [10]
  Chen, B.; Chen, D.; Li, F.; Lin, X.; Huang, Q. Graphitic porous carbon: efficient synthesis by a combustion method and application as a highly selective biosensor. J. Mater. Chem. B 2018, 6, 7684−7691. doi: 10.1039/C8TB02139B
11. [11]
  Huang, Q.; Lin, X.; Zhu, J. J.; Tong, Q. X. Pd-Au@ carbon dots nanocomposite: facile synthesis and application as an ultrasensitive electrochemical biosensor for determination of colitoxin DNA in human serum. Biosens. Bioelectron. 2017, 94, 507−512. doi: 10.1016/j.bios.2017.03.048
12. [12]
  Sakthivel, M.; Sivakumar, M.; Chen, S. M.; Hou, Y. S.; Veeramani, V.; Madhu, R. A facile synthesis of Cd(OH)₂-rGO nanocomposites for the practical electrochemical detection of acetaminophen. Miyamoto. N. Electroanal. 2017, 29, 280−286. doi: 10.1002/elan.201600351
13. [13]
  Fu, L.; Lai, G.; Yu, A. Preparation of β-cyclodextrin functionalized reduced graphene oxide: application for electrochemical determination of paracetamol. RSC Adv. 2015, 5, 76973−76978. doi: 10.1039/C5RA12520K
14. [14]
  Huang, T. Y.; Kung, C. W.; Wei, H. Y.; Boopathi, K. M.; Chu, C. W.; Ho, K. C. A high performance electrochemical sensor for acetaminophen based on a rGO-PEDOT nanotube composite modified electrode. J. Mater. Chem. A 2014, 2, 7229−7237. doi: 10.1039/C4TA00309H
15. [15]
  Lu, Y.; Yu, L.; Wu, M.; Wang, Y.; Lou, X. W. Construction of complex Co₃O₄@Co₃V₂O₈ hollow structures from metal-organic frameworks with enhanced lithium storage properties. Adv. Mater. 2018, 30, 1702875−1702884. doi: 10.1002/adma.201702875
16. [16]
  Li, G. M.; Chen, Y. Z.; Ouyang, Y.; Yao, D.; Lu, L.; Wang, L.; Xia, X.; Lei, W.; Chen, S. M.; Mandler, D.; Hao, Q. Manganese doped Co₃O₄ mesoporous nanoneedle array for long cycle-stable supercapacitors. Appl. Surf. Sci. 2019, 469, 941−950. doi: 10.1016/j.apsusc.2018.11.099
17. [17]
  Dan, Y. Y.; Sun, Y. Y.; Lu, C.; Feng, W. C.; Liu, G.; Cheng, X. F.; Chen, L. Z.; Cheng, K.; Muralidharan, G. Composite electrodeposited PbO₂/Co₃O₄ on a Ti substrate as positive electrode materials for a hybrid supercapacitor. Chin. J. Struct. Chem. 2019, 38, 882−892.
18. [18]
  Naqvi, T. K.; Srivastava, A. K.; Kulkarni, M. M.; Siddiqui, A. M.; Dwivedi, P. K. Silver nanoparticles decorated reduced graphene oxide (rGO) SERS sensor for multiple analytes. Appl. Surf. Sci. 2019, 478, 887−895. doi: 10.1016/j.apsusc.2019.02.026
19. [19]
  Wei, H. Z.; Wang, X. X.; Li, L.; Gong, Z. H.; Zhang, Y. F.; Jia, G. X. A first-principles study on the gas sensitivity of metal-loaded graphene with an atomic vacancy to O₂. Chin. J. Struct. Chem. 2019, 2, 187−194.
20. [20]
  Zhang, X. F.; Zhang, B. Y.; Liu, S. S.; Kang, H. W.; Kong, W. Q.; Zhang, S. R.; Shen, Y.; Yang, B. C. RGO modified Ni doped FeOOH for enhanced electrochemical and photoelectrochemical water oxidation. Appl. Surf. Sci. 2018, 436, 974−980. doi: 10.1016/j.apsusc.2017.12.078
21. [21]
  Ponnaiah, S. K.; Prakash, P.; Vellaichamy, B. A new analytical device incorporating a nitrogen doped lanthanum metal oxide with reduced graphene oxide sheets for paracetamol sensing. Ultrason. Sonochem. 2018, 44, 196−203. doi: 10.1016/j.ultsonch.2018.02.016
22. [22]
  Wang, H. J.; Zhan, S. Y.; Li, S. F.; Qu, J. Y. Electrochemical sensor based on palladium-reduced graphene oxide modified with gold nanoparticles for simultaneous determination of acetaminophen and 4-aminopheno. Talanta 2018, 178, 188−194. doi: 10.1016/j.talanta.2017.09.021
23. [23]
  Hummers, J. W. S.; Offeman, R. E. Preparation of graphitic oxide. J. Am. Chem. Soc. 1958, 80, 1339−1339. doi: 10.1021/ja01539a017
24. [24]
  Stobinsk, L.; Lesiak, B.; Malolepszy, A.; Mazurkiewicz, M.; Mierzwa, B.; Zemek, J.; Jiricek, P.; Bieloshapka, I. Graphene oxide and reduced graphene oxide studied by the XRD, TEM and electron spectroscopy methods. J. Electron. Spectrosc. 2014, 195, 145−154. doi: 10.1016/j.elspec.2014.07.003
25. [25]
  Cho, S. H.; Jung, J. W.; Kim, C.; Kim, I. D. Rational design of 1-D Co₃O₄ nanofibers@ low content graphene composite anode for high performance Li-ion batteries. Sci. Rep. 2017, 7, 45105−9. doi: 10.1038/srep45105
26. [26]
  Rivas-Murias, B.; Salgueiriño, V. Thermodynamic CoO-Co₃O₄ crossover using Raman spectroscopy in magnetic octahedron-shaped nanocrystals. J. Raman Spectrosc. 2017, 48, 837−841. doi: 10.1002/jrs.5129
27. [27]
  Heller, E. J.; Yang, Y.; Kocia, L.; Chen, W.; Fang, S.; Borunda, M.; Kaxiras, E. Theory of graphene Raman scattering. ACS Nano. 2016, 10, 2803−2818. doi: 10.1021/acsnano.5b07676
28. [28]
  Song, N. J.; Lu, C. X.; Chen, C. M.; Ma, C. L.; Kong, Q. Q. Effect of annealing temperature on the mechanical properties of flexible graphene films. New Carbon Mater. 2017, 32, 221−226. doi: 10.1016/S1872-5805(17)60119-7
29. [29]
  Laviron, E. General expression of the linear potential sweep voltammogram in the case of diffusionless electrochemical systems. J. Electroanal. Chem. 1979, 101, 19−28. doi: 10.1016/S0022-0728(79)80075-3
30. [30]
  Baccarin, M.; Santos, F.; Vicentini, F.; Zucolotto, V.; Janegitz, B.; Fatibello-Filho, O. Electrochemical sensor based on reduced graphene oxide/carbon black/chitosan composite for the simultaneous determination of dopamine and paracetamol concentrations in urine samples. J. Electroanal. Chem. 2017, 799, 436−443. doi: 10.1016/j.jelechem.2017.06.052
31. [31]
  Ibáñez-Redín, G.; Wilson, D.; Gonçalves, D.; Oliveira, O. N. Low-cost screen-printed electrodes based on electrochemically reduced graphene oxide-carbon black nanocomposites for dopamine, epinephrine and paracetamol detection. J. Colloid Interf. Sci. 2018, 515, 101−108. doi: 10.1016/j.jcis.2017.12.085
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Co3O4/reduced Graphene Oxide Composite as An Enhanced Material for Electrochemical Detection of Paracetamol in Human Serum

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Co₃O₄/reduced Graphene Oxide Composite as An Enhanced Material for Electrochemical Detection of Paracetamol in Human Serum