Citation: KONG Du-Lin, JIANG Jie, WU Lu-Yong, WANG Xiang-Hui, SHI Zai-Feng, WU Ming-Shu, WANG Xin, LIN Qiang. Synthesis, Structure and Antimicrobial Activity of 9,9-Dimethyl-9,10-dihydrospiro[benzo[a]-xanthene-12,3'-indoline]-2',11(8H)-dione[J]. Chinese Journal of Structural Chemistry, ;2016, 35(12): 1849-1854. doi: 10.14102/j.cnki.0254-5861.2011-1249 shu

Synthesis, Structure and Antimicrobial Activity of 9,9-Dimethyl-9,10-dihydrospiro[benzo[a]-xanthene-12,3'-indoline]-2',11(8H)-dione

KONG Du-Lin ^a,b ,
JIANG Jie ^c ,
WU Lu-Yong ^c ,
WANG Xiang-Hui ^c ,
SHI Zai-Feng ^c ,
WU Ming-Shu ^c,*,, ,
WANG Xin ^a,*,, ,
LIN Qiang ^a,c,*,,

a.
College of Chemical Engineering, Nanjing University of Science & Technology, 200 Xiaolingwei, Nanjing 210094, China
b.
School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571199, China
c.
Key Laboratory of Tropical Medicinal Plant Chemistry of the Ministry of Education, College of Chemistry & Chemical Engineering, Hainan Normal University, Haikou 571158, China

Corresponding author: WU Ming-Shu, wmsh@hainuu.edu.cn WANG Xin, wangx@njust.edu.cn LIN Qiang, linqianggroup@163.com
Received Date: 15 April 2016
Accepted Date: 9 August 2016

Fund Project: Natural Science Foundation of Hainan Province 20162033Cultivation Research Foundation of Hainan Medical University HY2015-02

Figures(4)

One novel spiro-compound (C₂₆H₂₁NO₃) has been synthesized and characterized by means of NMR spectroscopy, elemental analyses and X-ray diffraction. The single crystal belongs to the monoclinic system, space group P2₁/c with a=8.8039(7), b=24.123(2), c=10.0751(9)Å, β=108.403(3)°, M_r=395.44, V=2030.3(3)Å³, Z=4, D_c=1.294 g/cm³, F(000)=832.0, μ=0.085 mm^-1, R=0.0801 and wR=0.2228. The title compound shows good activities against Micrococcus tetragenus, Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, S. albus and Escherichia coli.
- synthesis,
- crystal structure,
- spirooxindole ring,
- heterocycle,
- antimicrobial activity
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