Citation: WANG Qiao, ZHAI Zhi-Wen, SUN Zhao-Hui, LIU Xing-Hai, TAN Cheng-Xia, WENG Jian-Quan. Synthesis, Crystal Structure and Antifungal Activity of 8-Chloro-3-((4-chlorobenzyl)-thio)[1,2,4]triazolo[4,3-a]pyridine[J]. Chinese Journal of Structural Chemistry, ;2016, 35(4): 651-655. doi: 10.14102/j.cnki.0254-5861.2011-1022 shu

Synthesis, Crystal Structure and Antifungal Activity of 8-Chloro-3-((4-chlorobenzyl)-thio)[1,2,4]triazolo[4,3-a]pyridine

1.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China

Received Date: 25 October 2015
Available Online: 22 February 2016
Fund Project: This work was funded by the National Natural Science Foundation of China (No. 21002090) (No. 21002090) the Natural Science Foundation of Zhejiang Province (No. LY16C140007) (No. LY16C140007)

The title compound 8-chloro-3-((4-chlorobenzyl)thio)-[1,2,4]triazolo[4,3-a]pyridine was prepared from 1-chloro-4-(chloromethyl)benzene and 8-chloro-[1,2,4]triazolo[4,3-a]pyridine-3(2H)-thione in the presence of NaOH, and its structure was determined by X-ray diffraction analysis. The crystal is of triclinic system, space group P1 with a=6.8264(6), b=7.5890(4), c=13.0960(7) Å, α=93.447(4), β=98.772(6), γ=92.615(6)°, V=668.26(8) Å³, Z=2, the final R=0.035 and wR=0.09 for 2259 observed reflections with I > 2σ(I). The preliminary biological test showed that the title compound has activities against Stemphylium lycopersici (Enjoji) Yamamoto, Fusarium oxysporum. sp. cucumebrium, and Botrytis cinerea with inhibitory to be 51.19%, 62.02% and 15.56%, respectively.
- 1,2,4-triazolo[4,3-a]pyridine,
- synthesis,
- crystal structure,
- antifungal activity
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