Citation: Man WANG, Fei YU, Wu-Jiu JIANG, Yu-Xing TAN, Fu-Xing ZHANG, Dai-Zhi KUANG. Syntheses, Crystal Structures and Biological Activity of the Diorganotin 2-(2-(4-Methoxybenzoyl)hydrazono)-3-phenylpropanoic Carboxylate Complexes[J]. Chinese Journal of Structural Chemistry, ;2020, 39(11): 1965-1972. doi: 10.14102/j.cnki.0254–5861.2011–2747 shu

Syntheses, Crystal Structures and Biological Activity of the Diorganotin 2-(2-(4-Methoxybenzoyl)hydrazono)-3-phenylpropanoic Carboxylate Complexes

Key Laboratory of Functional Metal-organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: Wu-Jiu JIANG, Yu-Xing TAN,
Received Date: 30 January 2020
Accepted Date: 25 March 2020

Fund Project: Hengyang Normal University College Students Scientific and Technological Works Project 167Hengyang Normal University College Students Scientific and Technological Works Project 168Foundation of Key Laboratory of Functional Organometallic Materials, University of Hunan Province GN19K07Scientific Research Fund of Hunan Provincial Education Department of China 19C0279Hengyang Normal University Industrial Supported Project HXKJ201908Hengyang Normal University Industrial Supported Project HXKJ201911Hengyang Normal University Industrial Supported Project HXKJ201946Hengyang Normal University Industrial Supported Project HXKJ201947

Figures(4)

Diorganotin 2-(2-(4-methoxybenzoyl)hydrazono)-3-phenylpropanoic carboxylate complexes I {[p-CH₃O-C₆H₄O(O)C=N-N=C(PhCH₂)COO](n-Bu)₂Sn(CH₃OH)}₂ and II {[p-CH₃O-C₆H₄O(O)C=N-N=C(PhCH₂)COO](PhCH₂)₂Sn(CH₃OH)}₂ have been synthesized. The complexes have been characterized by IR, ¹H, ¹³C and ¹¹⁹Sn NMR spectra, HRMS, elemental analysis, thermal stability analysis and the crystal structures have been determined by X-ray diffraction. The crystal of complex I belongs to triclinic system, space group P\begin{document}$ \overline 1 $\end{document} with a = 10.437(2), b = 11.576(3), c = 13.085(3) Å, α = 66.272(2)°, β = 86.920(3)°, γ = 73.367(3)°, Z = 2, V = 1383.3(5) Å³, D_c = 1.381 Mg·m^–3, μ(MoKα) = 0.959 mm^–1, F(000) = 592, R = 0.0233 and wR = 0.0644. The crystal of complex II is of triclinic system, space group P\begin{document}$ \overline 1 $\end{document} with a =10.446(1), b = 11.720(1), c = 13.063(2) Å, α = 84.190(1)°, β = 71.610(1)°, γ = 72.624(1)°, Z = 1, V = 1448.3(3) Å³, D_c = 1.475 Mg·m^–3, μ(MoKα) = 0.925 mm^–1, F(000) = 656, R = 0.0169 and wR = 0.0432. In vitro antitumor activities of both complexes were evaluated by MTT against three human cancer cell lines (NCI-H460, HepG2 and MCF7), and two complexes exhibited good antitumor activity. The interaction between complex I and calf thymus DNA were studied by UV-vis and fluorescence spectroscopy, the interaction of complex I with calf thymus DNA were intercalation.
- diorganotin,
- carboxylate,
- synthesis,
- crystal structure,
- biological activity
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